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Application of the composition extracted from black pepper in the preparation of cough medicine

A technology of black pepper and a composition is applied in the application field of the composition extracted from black pepper in the preparation of cough medicine, and can solve the problems of high drug resistance, large toxic and side effects, and the like

Active Publication Date: 2016-02-10
BEIJING KANG LISHENG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current central antitussives and peripheral antitussives, such as dextromethorphan, pentoxyverine, benproperine, and narcodine, all have side effects such as high toxicity and high drug resistance.

Method used

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  • Application of the composition extracted from black pepper in the preparation of cough medicine
  • Application of the composition extracted from black pepper in the preparation of cough medicine
  • Application of the composition extracted from black pepper in the preparation of cough medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A composition extracted from black pepper, characterized in that: it is made according to the following preparation method:

[0032] (1) black pepper percolates with 10 times the weight of sherwood oil to extract volatile oil, for subsequent use;

[0033] (2) extract the black pepper of devolatilized oil with 10 times of weight of ethanol, filter the extract, concentrate to a certain volume and pass through anion exchange resin, and use 5% hydrochloric acid solution of 10 times of weight of the concentrate as eluent, and the obtained wash Deliquification and concentration, and then passing through D101 macroporous adsorption resin, using 95% ethanol solution 10 times the weight of the concentrate as an eluent, and concentrating the obtained eluent under reduced pressure to obtain total alkaloids of black pepper;

[0034] The above-mentioned black pepper volatile oil and black pepper total alkaloids are mixed in a weight ratio of 1:3 to obtain a pharmaceutical compositio...

Embodiment 2

[0038] A composition extracted from black pepper, characterized in that: it is made according to the following preparation method:

[0039] (1) black pepper percolates with 10 times the weight of sherwood oil to extract volatile oil, for subsequent use;

[0040] (2) extract the black pepper of devolatilized oil with 10 times the weight of ethanol, filter the extract, concentrate to a certain volume and pass through an anion exchange resin, use 10 times the weight of the concentrate 5% hydrochloric acid solution as eluent, the obtained elution Concentrate the solution, pass through D101 macroporous adsorption resin again, use 95% ethanol solution of 5 times the weight of the concentrate as the eluent as the eluent, and the 95% ethanol solution contains polyethylene glycol 2000 and sodium bicarbonate, and the obtained elution The liquid is concentrated under reduced pressure to obtain the total alkaloids of black pepper;

[0041] The 95% ethanol solution contains polyethylene g...

Embodiment 3

[0046] (1) black pepper percolates with 10 times the weight of sherwood oil to extract volatile oil, for subsequent use;

[0047] (2) extract the black pepper of devolatilized oil with 10 times the weight of ethanol, filter the extract, concentrate to a certain volume and pass through an anion exchange resin, use 10 times the weight of the concentrate 5% hydrochloric acid solution as eluent, the obtained elution The solution is concentrated, and then passed through D101 macroporous adsorption resin, with 5 times the weight of the concentrate in 95% ethanol solution as the eluent as the eluent, and the 95% ethanol solution contains polyethylene glycol 2000 and sodium carbonate, and the resulting eluate Concentrate under reduced pressure to obtain total alkaloids of black pepper;

[0048] The 95% ethanol solution contains polyethylene glycol and sodium bicarbonate, wherein the weight ratio is: 60 parts by weight of the 95% ethanol solution, 10 parts by weight of polyethylene gly...

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Abstract

The invention relates to a composition extracted by black pepper. The medicine composition is obtained by mixing black-pepper volatile oil and black-pepper total alkaloid according to the proportion.

Description

technical field [0001] The invention relates to a composition extracted from black pepper and its application in the preparation of medicines for antitussive, phlegm-reducing and upper respiratory tract inflammation. Background technique [0002] Black pepper, a vine, belongs to the pepper family. It is dried and processed from the spherical berries of the pepper family. Those with black peels are called black pepper. Introduced in Hainan, China, and then successfully introduced and tested in Guangdong, Yunnan, Guangxi, Fujian and other provinces. Planting pepper is now an industry in Hainan Province. Pepper has many food and pharmaceutical uses. Black pepper is an excellent food seasoning and edible spice with antiseptic effects; it can extract piperine, piperine, and piperine A, B, C and other alkaloids and volatile oils have the functions of calming, warming and dispelling cold, lowering Qi, invigorating the stomach, relieving pain, reducing inflammation, detoxifying, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/67A61P11/14A61P11/10A61P11/00
Inventor 程刚
Owner BEIJING KANG LISHENG PHARMA TECH DEV
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