Antihistamine and sleep promotion composition and soft capsules

A sleep-promoting and anti-histamine technology, applied in capsule delivery, drug combination, medical preparations containing active ingredients, etc., can solve problems such as insufficient effects, complicated prescriptions, side effects, etc., and achieve mild inhibition Smooth muscle contraction, reasonable ratio, and the effect of improving vertigo

Active Publication Date: 2014-03-26
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For such a variety of insomnia patients, the existing antihistamines not only have complicated prescriptions, but also fail to obtain sufficient effects when used as sleep-improving pharmaceutical compositions
[0005] Moreove...

Method used

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  • Antihistamine and sleep promotion composition and soft capsules
  • Antihistamine and sleep promotion composition and soft capsules
  • Antihistamine and sleep promotion composition and soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The antihistamine and sleep-promoting composition of the present invention comprises the following components by weight percentage:

[0034] Diphenhydramine Hydrochloride 12.5%

[0035] Polyethylene glycol 75.5%

[0036] Polyol 12%

[0037] Wherein said polyethylene glycol is polyethylene glycol 400; said polyhydric alcohol is propylene glycol. Example 2

Embodiment 2

[0038] The antihistamine and sleep-promoting composition of the present invention comprises the following components by weight percentage:

[0039] Diphenhydramine Hydrochloride 12.5%

[0040] Polyethylene glycol 80.0%

[0041] Polyol 7.5%

[0042] Wherein said polyethylene glycol is polyethylene glycol 200; said polyhydric alcohol is the mixture of glycerol and propylene glycol.

Embodiment 3

[0044] The antihistamine and sleep-promoting composition of the present invention comprises the following components by weight percentage:

[0045] Diphenhydramine Hydrochloride 12.5%

[0046] Polyethylene glycol 77.5%

[0047] Polyol 10%

[0048] Wherein said polyethylene glycol is the mixture of polyethylene glycol 200 and polyethylene glycol 400. Described polyhydric alcohol is the mixture of propylene glycol and glycerin.

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Abstract

The invention discloses an antihistamine and sleep promotion composition and soft capsules. The composition comprises the following components in percentage by weight: 5-45% of diphenhydramine hydrochloride, 30-90% of polyethylene glycol and 1-25% of polyalcohol. Each soft capsule comprises soft capsule rubber cover and content, wherein the content comprises the following components in percentage by weight: 5-45% of diphenhydramine hydrochloride, 30-90% of polyethylene glycol and 1-25% of polyalcohol; the soft capsule rubber cover comprises the following components in percentage by weight: 50-90% of gelatin, 5-70% of plasticizer, 5-15% of purified water and 0-0.5% of coloring agent. The invention aims at providing an antihistamine and sleep promotion composition which is simple in composition, stable and effective and fast in dissolution and absorption, and soft capsules containing the antihistamine and sleep promotion composition. The soft capsules disclosed by the invention are suitable for the allergy of the skin mucosa, prevention of motion sickness, Parkinson's disease and extrapyramidal symptoms for calming and hypnosis, enhance the effects of cough medicines, and are suitable for the cough caused by cold or allergy.

Description

technical field [0001] The invention relates to a composition for antihistamine and sleep promotion, and also relates to a soft capsule containing the composition. Background technique [0002] Many people suffer from insomnia due to social pressure and unfavorable environment. After investigation, about 80% of modern people have the experience of insomnia. [0003] For such insomnia, antihistamines are used as active ingredients in the U.S., U.K., Germany, Canada, and other European and American countries, as well as in Japan, as general medicines or sleep-improving pharmaceutical compositions that do not require a prescription. To reduce temporary insomnia symptoms. [0004] However, depending on the state of insomnia, there are various forms such as trouble falling asleep, trouble falling asleep, waking up midway, or waking up early. For such a variety of insomnia patients, the existing antihistamines not only have complex prescriptions, but also fail to obtain suffici...

Claims

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Application Information

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IPC IPC(8): A61K31/135A61K9/48A61P37/08A61P25/20A61P1/08A61P25/16A61P11/14
Inventor 余凯琳贾卫东
Owner 安士制药(中山)有限公司
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