41 results about "Chlortetracycline Hydrochloride" patented technology

The invention provides a chlortetracycline premix and a preparation method thereof. By weight, the premix contains 10-20 parts of chlortetracycline hydrochloride, 50-60 parts of calcium carbonate, 10-30 parts of corn starch, 10-15 parts of an adhesive, and 5-10 parts of enteric polyacrylic resin, wherein the adhesive is microcrystalline cellulose and/or dextrin. The prescription of the chlortetracycline premix provided in the invention is more suitable for a dry granulation process, can significantly improve one-time yield and increase product fluidity and slow release property, thus solving the difficulties of a dry granulation process of the chlortetracycline premix. During mass production, the chlortetracycline hydrochloride premix can achieve good uniformity, and generates less dust. In addition, the premix can guarantee that the chlortetracycline hydrochloride is incompletely released in gastric juice, thus enhancing the utilization degree of chlortetracycline hydrochloride.

The invention discloses a formula of veterinary chlortetracycline hydrochloride soluble powder and a preparation method thereof. The soluble powder is prepared from the following components in percentage by weight: 10-50 percent of chlortetracycline hydrochloride, 0.2-3.0 percent of sodium dodecyl sulfate, 0.1-1.0 percent of ethylenediamine tetraacetic acid disodium salt and the balance of glucosum anhydricum. The chlortetracycline hydrochloride is utilized as a raw material, sodium dodecyl sulfate is added as an absorption enhancer, and ethylenediamine tetraacetic acid disodium salt is utilized as an antioxidant and a chelating agent, so that the stability and high efficiency of chlortetracycline hydrochloride soluble powder are ensured.

The invention relates to a method for preparing a standard substance for detecting antibiotics in cosmetics. The standard substance is formed by mixing aqueous solution of the antibiotics or solution of propylene glycol and cosmetic cream, wherein the cosmetic cream comprises the following components in percentage by weight: 73 to 78 percent of de-ionized water, 3 to 3.5 percent of propylene glycol and 0.2 to 0.25 percent of carbomer in phase A, 4.5 to 5 percent of stearate, 3 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of 26# white oil in phase B and 1.2 to 1.25 percent of phenoxyethanol and ethylhexylglycerin in phase C; and the concentration of the antibiotics in the standard substance reaches 0.1g/100mL. The method has the advantages that: the antibiotics and the cosmetic cream are mixed to form the standard substance for detecting the antibiotics such as minocycline hydrochloride, oxytetracycline dehydrate, tetracycline hydrochloride, chlortetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol in the cosmetic; and the standard substance is the same as a sample of the cosmetic containing the antibiotics in the actual use; thus the detection of the antibiotics in the cosmetic conforms to the state of the actual application better and is more accurate.

The invention discloses a veterinary-use intestinal targeted antibacterial pellet. The veterinary-use intestinal targeted antibacterial pellet comprises a main drug and auxiliary drugs, wherein the main drug is composed of valnemulin hydrochloride and chlortetracycline hydrochloride; the mass of the valnemulin hydrochloride is 1-5% of that of the pellet; the mass of the chlortetracycline hydrochloride is 5-16 times of that of the valnemulin hydrochloride; the pellet sequentially comprises a valnemulin hydrochloride core, an intestinal targeted coating layer, a chlortetracycline hydrochloride drug layer and an outer coating layer from inside to outside. The invention further discloses a preparation method of the veterinary-use intestinal targeted antibacterial pellet. Through the combination of the method and the formula, the valnemulin hydrochloride and the chlortetracycline hydrochloride are adopted for preparing the pellet; the pellet is released in a gradient form in an animal digestion system; the chlortetracycline hydrochloride is firstly released and absorbed by the stomach and the intestine; the valnemulin hydrochloride is rapidly released and absorbed by the intestinal tract with the pH value larger than or equal to 6.8, so that an excellent intestinal tract sterilization effect is achieved, the drug absorbed by the colon can be prevented from suffering from the first-pass effect of the liver and the intestine, the haemoconcentration and bioavailability of the valnemulin hydrochloride can be improved, and an excellent treatment effect for systemic diseases is obtained.

The invention provides a chlortetracycline hydrochloride soluble powder and belongs to the technical field of veterinary drugs. The chlortetracycline hydrochloride soluble powder is prepared from, bymass, 10-50 parts of chlortetracycline hydrochloride, 5-10 parts of carbomer, 5-25 parts of citric acid, 20-40 parts of glycine, 0.1-0.5 part of sodium hydrogen sulfite and 10-40 parts of hydroxypropyl-beta-cyclodextrin. The invention also provides a preparation method of the chlortetracycline hydrochloride soluble powder. The preparation method includes the steps of weighing the above raw materials by mass, and respectively crushing the raw materials; mixing the crushed raw materials with water and shaking to obtain raw material aqueous solution; drying the raw material aqueous solution andgranulating to obtain the chlortetracycline hydrochloride soluble powder. The chlortetracycline hydrochloride soluble powder prepared by the method has good stability and good solubility, and treatment effects are obviously better than that of the traditional chlortetracycline hydrochloride soluble powder.

The invention relates to a preparation method of hydrochloric acid aureomycin; the technical steps are listed below: firstly acidifying aureomycin broth; adjusting pH to 2-2.5; standing; continuously adjusting pH to 4-4.5; standing; adding water to reduce viscosity to 3000-4000cps pretreatment; carrying out membrane filtration, nanofiltration, crystallization, washing, salt forming, leaching and drying to obtain hydrochloric acid aureomycin powders. The method can improve extraction yield of the hydrochloric acid aureomycin, reduces production cycle and cost, and improves hydrochloric acid aureomycin output.

The invention discloses a preparation method of ultrahigh water-soluble chlortetracycline hydrochloride. The preparation method specifically comprises the following steps: 1) acidifying fermentation liquor; 2) double salt; 3) coarse crystallization; 4) extracting; (5) recrystallizing; (6) performing high-pressure homogenization: performing high-pressure homogenization treatment on the material obtained in the step (1) by taking purified water as a dispersion medium according to a water-material ratio of 1: (1-1.5) for 10-12 times; and 7) spray drying: carrying out spray drying treatment on the material obtained in the previous step, controlling the feeding frequency to be 20Hz and the air inlet temperature to be 175-180 DEG C to obtain the ultrahigh water-soluble chlortetracycline hydrochloride.

The invention discloses a plastering film for treating ulcerative stomatitis and its preparation, wherein the medicament is prepared from honeysuckle flower, menthol, vitamin B2, boneol, tetracaine hydrochloride, sorbic acid, prednisone acetate, chlortetracycline hydrochloride, glycerin, stevioside, ethanol, polyvinyl alcohol PVA17-88 and purified water.

The invention relates to a method for determining related substances of aureomycin hydrochloride by an HPLC gradient elution method. Specifically, the method for the present invention's determination of related substances in aureomycin hydrochloride or its preparations comprises the steps: (1) high performance liquid chromatography and chromatographic column are provided; (2) mobile phase is prepared; (3) test solution is prepared (4) Inject various test solutions into the liquid chromatograph respectively, measure according to the specified chromatographic conditions, record the chromatogram and calculate the content of each related substance in the test substance. The method of the present invention exhibits one or more excellent effects as described in the specification, such as low column pressure, small chromatographic peak drift and/or stable test solution.

The invention discloses a chlortetracycline premix, which consists of the following components in parts by weight: 15-25 parts of chlortetracycline hydrochloride, 10-20 parts of corn starch, 1-3 partsof N-trimethyl chitosan, 3-6 parts of a sweetening agent and 6-12 parts of a binding agent. The chlortetracycline premix, which is prepared in accordance with the prescription, is stable in quality and high in utilization rate; chlortetracycline, which is less released in gastric juice, can reach an intestinal tracts well so as to achieve good efficacy; and the chlortetracycline premix has a goodapplication prospect and is worthy of popularizing.

The invention discloses an enteric coating aureomycin premix, which comprises drug-loading pellets and a coating which is arranged outside the drug-loading pellets. The drug-loading pellets contain the following ingredients (by weight): 20-30 parts of chlortetracycline hydrochloride, 15-25 parts of low-substituted hydroxypropy cellulose, 5-10 parts of polyvinylpyrrolidone K30 and 1-3 parts of a sweetener. The coating contains the following ingredients (by weight): 20-30 parts of polyacrylic resin II, 2-6 parts of a plasticizer and 1-4 parts of talcum powder. According to the enteric coating aureomycin premix, polyacrylic resin II is insoluble in gastric juice but only soluble in intestinal juice such that aureomycin is effectively protected and won't be released or absorbed until reachingthe intestinal tract; the formula of the drug-loading pellets is reasonable, and the particles are small after disintegration of the low-substituted hydroxypropy cellulose, which is greatly beneficialto dissolution of the drug; and the enteric coating aureomycin premix has a good application prospect and is worthy of promotion.

The invention relates to a chlortetracycline hydrochloride dry suspension as well as a preparation method and application thereof, and the chlortetracycline hydrochloride dry suspension comprises the following raw materials in percentage by mass: 15-35% of chlortetracycline hydrochloride, 1-15% of a suspending aid, 1-5% of a pH value regulator, 0.1-1% of a flavoring agent and 44.9-82.9% of a filler. The method comprises the following steps: S1, crushing and sieving chlortetracycline hydrochloride; s2, sieving other auxiliary materials; s3, weighing the chlortetracycline hydrochloride, the suspending aid, the pH value adjusting agent and the flavoring agent according to the proportion, feeding the materials into a stirring tank in vacuum, and adding a proper amount of purified water to form a suspension; s4, carrying out spray drying on the suspension, and sieving with a 80-mesh sieve; and S5, uniformly mixing the product obtained by spraying with a filling agent in a mixing machine to obtain the chlortetracycline hydrochloride dry suspension. The product disclosed by the invention is acidic and can be used together with drugs which have synergistic interaction with chlortetracycline hydrochloride, the palatability of an aqueous solution is good, and clinical test results show that the product disclosed by the invention improves the clinical effect and the blood concentration of chlortetracycline hydrochloride.