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Chlortetracycline hydrochloride soluble powder and preparation method thereof

A chlortetracycline hydrochloride and soluble technology, which is applied in the field of chlortetracycline hydrochloride soluble powder and its preparation, can solve the problems of great influence on stability, precipitation, poor solubility, etc., so as to increase solubility and dissolution rate, and reduce stirring and dissolution. Time and content stable effect

Inactive Publication Date: 2019-11-29
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chlortetracycline hydrochloride soluble powder currently on the market has poor solubility, and it takes a long period of time to dissolve the chlortetracycline hydrochloride soluble powder according to the above method of use, and it has been found through tests that the water hardness is not as high as that of the chlortetracycline hydrochloride soluble powder. The stability after dissolution is greatly affected. Due to the large area of ​​our country, the water quality in various provinces and regions is different, especially the water used by farmers to feed animals is relatively hard, which will cause the solution of chlortetracycline hydrochloride soluble powder to be placed for a period of time. After a period of time, there will be precipitation, which will cause the solution content to drop, affect the use effect, and block the drinking water line

Method used

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  • Chlortetracycline hydrochloride soluble powder and preparation method thereof
  • Chlortetracycline hydrochloride soluble powder and preparation method thereof
  • Chlortetracycline hydrochloride soluble powder and preparation method thereof

Examples

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Effect test

Embodiment 1

[0022] A chlortetracycline hydrochloride soluble powder comprises the following raw materials in terms of mass percentage: 20% chlortetracycline hydrochloride, 10% anhydrous magnesium sulfate, 40% urea, 5% anhydrous citric acid, and 25% whitening aids. Its specific preparation method comprises the following steps:

[0023] S1, after crushing all raw materials, pass through an 80-mesh analytical sieve, and then take the sieved raw materials according to the above raw material ratio;

[0024] S2. Add chlortetracycline hydrochloride to the auxiliary whitening product by the method of increasing in equal amounts, and pre-mix for 20 minutes to obtain a premix;

[0025] S3. Add urea, anhydrous magnesium sulfate and anhydrous citric acid to the premix obtained in step S2 in equal increments, and continue mixing for 20 minutes.

Embodiment 2

[0027] A chlortetracycline hydrochloride soluble powder comprises the following raw materials in terms of mass percentage: 10% chlortetracycline hydrochloride, 5% anhydrous magnesium sulfate, 30% urea, 10% salicylic acid and 45% anhydrous glucose. Its specific preparation method comprises the following steps:

[0028] S1, after crushing all raw materials, pass through an 80-mesh analytical sieve, and then take the sieved raw materials according to the above raw material ratio;

[0029] S2. Add aureomycin hydrochloride to anhydrous glucose according to the method of equal increase, and pre-mix for 10 minutes to obtain a premix;

[0030] S3. Add urea, anhydrous magnesium sulfate and salicylic acid to the premix obtained in step S2 in equal amounts, and continue mixing for 10 minutes.

Embodiment 3

[0032] A chlortetracycline hydrochloride soluble powder, comprising the following raw materials by mass percentage: chlortetracycline hydrochloride 20%, anhydrous magnesium sulfate 10%, urea 20%, malic acid 10%, auxiliary whitening 20%, anhydrous glucose 20% %. Its specific preparation method comprises the following steps:

[0033] S1, after crushing all raw materials, pass through an 80-mesh analytical sieve, and then take the sieved raw materials according to the above raw material ratio;

[0034] S2. Add chlortetracycline hydrochloride to the whitening agent and anhydrous glucose according to the method of equal increase, and pre-mix for 30 minutes to obtain a premix;

[0035] S3. Add urea, anhydrous magnesium sulfate and malic acid to the premix obtained in step S2 in equal amounts, and continue mixing for 30 minutes.

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Abstract

The invention discloses chlortetracycline hydrochloride soluble powder and a preparation method thereof. The chlortetracycline hydrochloride soluble powder comprises the following raw materials (by mass): 10-20% of chlortetracycline hydrochloride, 10-40% of urea, 0-20% of a drying agent, 5-10% of a stabilizer and the balance of a carrier. By adding urea into the raw materials of the chlortetracycline hydrochloride soluble powder, solubility of the chlortetracycline hydrochloride soluble powder in water can be improved; dissolvability and dissolution rate of the chlortetracycline hydrochloridesoluble powder in water are improved; the stirring and dissolving time of the chlortetracycline hydrochloride soluble powder in use is greatly shortened; moreover, the chlortetracycline hydrochloridesoluble powder can be stably stored after being dissolved in water with different hardness, precipitation is avoided, the content of chlortetracycline hydrochloride in the solution is stable, the lossof the chlortetracycline hydrochloride soluble powder in use is reduced, and a drinking line is prevented from being blocked by precipitates. The chlortetracycline hydrochloride soluble powder is suitable for the situation that the water quality difference of farms in different regions is large.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a chlortetracycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Chlortetracycline hydrochloride is golden yellow or yellow crystal, odorless, bitter taste, gradually darkens when exposed to light, slightly soluble in water or ethanol, almost insoluble in acetone, ether or chloroform. At present, the chlortetracycline hydrochloride products on the market include chlortetracycline hydrochloride premix and chlortetracycline hydrochloride soluble powder. Among them, chlortetracycline hydrochloride soluble powder is a tetracycline antibiotic, which has a strong effect on Gram-positive bacteria such as Staphylococcus, hemolytic streptococcus, Bacillus anthracis, Clostridium tetani and Clostridium, and has a strong effect on Escherichia coli. Gram-negative bacteria such as Salmonella, Brucella and Pasteurella are more sensiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K47/18A61K47/12A61K31/65A61P31/04
CPCA61K9/143A61K9/145A61K31/65A61P31/04
Inventor 黎剑坤刘肖娟谭志坚
Owner FOSHAN STANDARD BIO TECH
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