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Formula and preparation method of veterinary injectant for preventing and treating endometritis

A technology for endometritis and infusion, which is applied in pharmaceutical formulations, drug delivery, sexually transmitted diseases, etc., can solve the problems of difficult to achieve effective concentration of drugs, insufficient active ingredient content, excessive antibiotic residues, etc., to prevent and inhibit reproduction, Good preventive and therapeutic effects, and the effect of promoting the growth of livestock and poultry

Inactive Publication Date: 2014-12-10
PIZHOU ZHENGKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when systemic treatment is used, it is difficult to achieve or maintain an effective concentration of drugs, and a large amount of antibiotics may easily lead to excessive antibiotic residues in blood and milk (meat) products
Local treatment is mainly to wash the uterus and inject drugs into the uterus. However, when the antibiotics reach the inflammatory site, the active ingredient content is insufficient; if the dosage of antibiotics is increased, it is easy to cause bacterial resistance and antibiotic residues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Chlortetracycline hydrochloride: 100g;

[0027] Disodium edetate: 0.2g;

[0028] Sodium sulfite: 2g;

[0029] Glycerol formal: 100mL;

[0030] Propylene glycol: 400mL;

[0031] Ethanol: 100mL;

[0032] Add water for injection to 1000mL.

[0033] Preparation:

[0034] 1) Weigh disodium edetate and sodium sulfite in the formula, and dissolve them in water for injection to form liquid A;

[0035] 2) Weigh aureomycin hydrochloride in the formula, and dissolve it in a composite solvent composed of propylene glycol, glycerin formal, and ethanol to form liquid B;

[0036] 3) Add liquid A to liquid B, stir evenly, make up to volume with water for injection, slowly add pH regulator to mix aureomycin hydrochloride evenly, adjust pH to 4.5-8.0, dispense into sterile brown bottles, and cap ,Package.

Embodiment 2

[0038] Chlortetracycline hydrochloride: 100g;

[0039] Disodium edetate: 0.2g;

[0040] Sodium bisulfite: 2g;

[0041] Glycerin formal: 300mL;

[0042] Add water for injection to 1000mL.

[0043] Preparation:

[0044] 1) Weigh disodium edetate and sodium bisulfite in the formula, and dissolve them in water for injection to form liquid A;

[0045] 2) Weigh aureomycin hydrochloride in the formula and dissolve it in glycerin formal to form liquid B;

[0046] 3) Add liquid A to liquid B, stir evenly, make up to volume with water for injection, slowly add pH regulator to mix aureomycin hydrochloride evenly, adjust pH to 4.5-8.0, dispense into sterile brown bottles, and cap ,Package.

Embodiment 3

[0048] Chlortetracycline hydrochloride: 100g;

[0049] Disodium edetate: 0.2g;

[0050] Sodium bisulfite: 2g;

[0051] Dimethylacetamide: 100mL;

[0052] Glycerol formal: 200mL;

[0053] Add water for injection to 1000mL.

[0054] Preparation:

[0055] 1) Weigh disodium edetate and sodium bisulfite in the formula, and dissolve them in water for injection to form liquid A;

[0056] 2) Weigh the aureomycin hydrochloride in the formula, dissolve it in the composite solvent composed of glycerol methylal and dimethylacetamide to be liquid B;

[0057] 3) Add liquid A to liquid B, stir evenly, make up to volume with water for injection, slowly add pH regulator to mix aureomycin hydrochloride evenly, adjust pH to 4.5-8.0, dispense into sterile brown bottles, and cap ,Package.

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PUM

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Abstract

The invention discloses a formula of veterinary injectant for preventing and treating endometritis. The injectant prepared according to the formula of every 1000mL of veterinary injectant for preventing and treating the endometritis comprises the following components by weight: 50-200g of chlortetracycline hydrochloride, 0.1-0.2g of cosolvent, 1-2g of antioxidant, 100-800g of composite organic solvent and 1-150g of pH value regulator. The invention also discloses a preparation method of the veterinary injectant for preventing and treating the endometritis. The veterinary injectant for preventing and treating the endometritis has the characteristics of having broad antibacterial spectrum, targeting, strong function, quick response and lasting effect and being directly accessed to lesions, can prevent and inhibit reproduction of pathogenic microorganisms in uterus and can avoid side effect due to excessive use of antibiotics.

Description

technical field [0001] The invention relates to a medicine and a method for preventing and treating endometritis, in particular to a formula and a preparation method of a veterinary injection for preventing and treating endometritis. Background technique [0002] Endometritis is an acute inflammation of the endometrium of mammals. It is a very common reproductive organ disease in female animals such as cows and pigs after childbirth: the disease is caused by many factors and pathogens, and the main reason is artificial insemination. , Lax disinfection during childbirth or midwifery, improper postpartum care and other invading bacteria cause infection. Studies have shown that common pathogenic bacteria include Streptococcus pyogenes, Staphylococcus, Escherichia coli, denatured bacillus, Corynebacterium pyogenes, diplococcus septicaemia, and Clostridium necrotizing etc.; pathogenic fungi, such as Candida, actinomycetes, Bacteria such as mucormycosis. In addition, vaginitis, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K9/08A61P15/00A61P31/04
Inventor 田勇王真真霍琳琳李灿
Owner PIZHOU ZHENGKANG BIOTECH
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