Method for preparing standard substance for detecting antibiotics in cosmetics

A standard substance and preparation method technology, applied in cosmetic preparations, cosmetic preparations, pharmaceutical formulas, etc., can solve the problems affecting the accuracy of detection, and achieve the effect of accurate detection

Active Publication Date: 2010-12-08
SHANGHAI INST OF MEASUREMENT & TESTING TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] The detection of antibiotics in cosmetics is one of the important guarantees for the safety of cosmetics. At present, direct compound detection methods are mostly used. However, in practical applications, after the ant

Method used

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  • Method for preparing standard substance for detecting antibiotics in cosmetics
  • Method for preparing standard substance for detecting antibiotics in cosmetics
  • Method for preparing standard substance for detecting antibiotics in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] According to formula and preparation process in the table, be mixed with cosmetic cream. The antibiotic chloramphenicol is formulated into 0.5g / 100mL aqueous solution or propylene glycol solution, then the aqueous solution or propylene glycol solution containing the antibiotic chloramphenicol is slowly added to the cosmetic cream, and the final concentration of chloramphenicol in the standard substance reaches 0.1g / 100mL, keep the temperature constant at about 20 ℃ and under the conditions of minimum water evaporation, stir slowly, and pack.

[0035] Chloramphenicol with a purity of ≥98% was provided by Sigma-Aldrich Shanghai Trading Co., Ltd.

Embodiment 2

[0037] According to formula and preparation process in the table, be mixed with cosmetic cream. The antibiotic minocycline hydrochloride is formulated into 0.5g / 100mL aqueous solution or propylene glycol solution, and then the aqueous solution or propylene glycol solution containing the antibiotic minocycline hydrochloride is slowly added to the cosmetic cream, and the concentration of minocycline hydrochloride in the standard substance The final concentration reaches 0.1g / 100mL, keep the temperature constant at about 20 ℃ and under the conditions of minimum water evaporation, stir slowly, and pack.

[0038] The purity of minocycline hydrochloride was >99.0%, provided by Sigma-Aldrich Shanghai Trading Co., Ltd.

Embodiment 3

[0040] According to formula and preparation process in the table, be mixed with cosmetic cream. The antibiotic oxytetracycline dihydrate is formulated into 0.5g / 100mL aqueous solution or propylene glycol solution, then the aqueous solution or propylene glycol solution containing the antibiotic oxytetracycline dihydrate is slowly added to the cosmetic cream, and the content of oxytetracycline dihydrate in the standard substance The final concentration reaches 0.1g / 100mL, keep the temperature constant at about 20 ℃ and under the conditions of minimum water evaporation, stir slowly, and pack.

[0041] The purity of oxytetracycline dihydrate was >99.0%, provided by Sigma-Aldrich Shanghai Trading Co., Ltd.

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Abstract

The invention relates to a method for preparing a standard substance for detecting antibiotics in cosmetics. The standard substance is formed by mixing aqueous solution of the antibiotics or solution of propylene glycol and cosmetic cream, wherein the cosmetic cream comprises the following components in percentage by weight: 73 to 78 percent of de-ionized water, 3 to 3.5 percent of propylene glycol and 0.2 to 0.25 percent of carbomer in phase A, 4.5 to 5 percent of stearate, 3 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of 26# white oil in phase B and 1.2 to 1.25 percent of phenoxyethanol and ethylhexylglycerin in phase C; and the concentration of the antibiotics in the standard substance reaches 0.1g/100mL. The method has the advantages that: the antibiotics and the cosmetic cream are mixed to form the standard substance for detecting the antibiotics such as minocycline hydrochloride, oxytetracycline dehydrate, tetracycline hydrochloride, chlortetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol in the cosmetic; and the standard substance is the same as a sample of the cosmetic containing the antibiotics in the actual use; thus the detection of the antibiotics in the cosmetic conforms to the state of the actual application better and is more accurate.

Description

technical field [0001] The invention relates to the field of cosmetic testing, in particular to a method for preparing standard substances for testing antibiotics in cosmetics. Background technique [0002] The detection of antibiotics in cosmetics is one of the important guarantees for the safety of cosmetics. At present, direct compound detection methods are mostly used. However, in practical applications, after the antibiotics in cosmetics are mixed with the ingredients of the formula, the detection will be compared with the direct use of compounds. There are large differences in detection, which will affect the accuracy of detection. Compared with standard compounds, cosmetic standard substances not only have accurate measurement standards, but also have one or more sufficiently uniform and well-determined characteristic values, and have traceability of the value, which is very important for improving cosmetics production, The detection level of cosmetics inspection, th...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/02A61K8/06A61K8/42
Inventor 陈黎明胡国胜
Owner SHANGHAI INST OF MEASUREMENT & TESTING TECH
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