Preparation method of hydrochloric acid aureomycin

Abstract

The invention relates to a preparation method of hydrochloric acid aureomycin; the technical steps are listed below: firstly acidifying aureomycin broth; adjusting pH to 2-2.5; standing; continuously adjusting pH to 4-4.5; standing; adding water to reduce viscosity to 3000-4000cps pretreatment; carrying out membrane filtration, nanofiltration, crystallization, washing, salt forming, leaching and drying to obtain hydrochloric acid aureomycin powders. The method can improve extraction yield of the hydrochloric acid aureomycin, reduces production cycle and cost, and improves hydrochloric acid aureomycin output.

Description

technical field [0001] The invention belongs to the technical field of antibiotic extraction and synthesis, in particular to a preparation method of aureomycin hydrochloride. Background technique [0002] Chlortetracycline hydrochloride is a tetracyclic antibiotic with broad-spectrum antibacterial activity. Its antibacterial spectrum is similar to tetracycline, and it has antibacterial activity against most Gram-positive bacteria and Gram-negative bacteria. In addition, they inhibit Rickettsiae and trachoma and lymphogranuloma viruses. [0003] At present, domestically disclosed methods for producing aureomycin hydrochloride mainly include: "Preparation Method of Aureomycin Hydrochloride" with application number 201210426529.0 and "A New Process for Preparation of Aureomycin Hydrochloride" with application number 201010218988.0. There are following problems in above-mentioned patent: [0004] 1 In the patent "Preparation Method of Chlortetracycline Hydrochloride", the plat...

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Problems solved by technology

[0004]1 In the patent "Preparation Method of Chlortetracycline Hydrochloride", plate and frame are used as filter equipment in the fermentation broth filtration process. In order to ensure the filtration yield, a large amount of clear water is required Wash the filter cake in the plate frame repeatedly to reduce the aureomycin remaining in the filter cake as much as possible, so the wastewater discharge is basically more than twice the volume of the fermentation broth, resulting in high wastewater treatment costs for enterprises and increased product production costs; At the same time, due to the use of plate and frame filter press, it occupies a large area, requires a lot of labor for cleaning, and the working environment is poor.

In the [0005]2 patent "Preparation Method of Chlortetracycline Hydrochloride", a large amount of ZnSO4 and Oxalic acid, and in the patent "A New Process for Preparing Chlortetracycline Hydrochloride", a large amount of divalent metal salts and monohydric alcohols are used in the chlortetracycline filtrate. The use of the above substances has led to a continuous increase in the production cost of chlortetracycline

[0006]3 The above two patented technologies use a large amount of divalent metal salts in the extraction process of chlortetracycline. Due to metal pollution, the filter cake and filtrate cannot be recovered. use, causing serious pollution to the local soil

[0007]4 In the above two patented technologies, during the alkalization process of aureomycin filtrate, it is difficult to avoid the phenomenon that the local concentration is too high, leading to its degradation

[0008]5 The patented technology "A New Process for Preparation of Chlortetracycline Hydrochloride" has the problem of unqualified finished product quality, mainly because the impurity content of the finished product exceeds the standard

[0009]6 Among the above two patented technologies, the extraction yield of chlortetracycline is generally 75-80%, which is low