Method for preparing chlortetracycline hydrochloride

A technology of chlortetracycline hydrochloride and preparation steps, which is applied in the field of pharmaceutical synthesis, can solve the problems of low product quality and active ingredients, many solvent waste liquids, long secondary crystallization process, etc., and achieves low cost, high safety and high activity. Effect

Inactive Publication Date: 2016-06-01
CHANGZHOU LANXU CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem that the present invention mainly solves: for current domestic production aureomycin hydrochloride adopts the secondary solvent crystallization method to produce more, the secondary crystallization process is long, the solvent waste liquid that produces produces is many, and product quality and active ingredient are low Problem, the present invention is by extracting the bacterial classification in the aureomycin slag, cultivates, and the bacterial classification in the cultivation is screened and modified by the modified additive solution, and simultaneously ferments under acidic conditions to promote the aureomycin fermentation in the fermentation process. content and make it easy to be acidified, and finally adsorbed by attapulgite, then desorbed by ultrasound, concentrated and dried to obtain aureomycin hydrochloride with high quality and activity

Method used

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Examples

Experimental program
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Effect test

example 1

[0018] In terms of percentage by weight, 43 parts of soybean meal, 14 parts of agar, 7 parts of blood meal, 24 parts of sucrose, 10 parts of 12% sodium chloride solution, 1.2 parts of dipotassium hydrogen phosphate and 0.8 parts of potassium dihydrogen phosphate , after stirring evenly, sterilize at 118°C for 35 minutes, adjust the pH to 5.5 with a hydrochloric acid solution with a mass fraction of 10%, and obtain a medium; measure 35mL of the above-prepared medium into a 250mL Erlenmeyer flask, and press solid-liquid Mix the chlortetracycline residue and the glucose solution with a mass fraction of 22% at a ratio of 1:3 and put it into a blender, stir it at 700r / min for 35min and let it stand for 12min, collect 80mL of the supernatant and put it into the Erlenmeyer flask for later use. ; According to the mass ratio of 1:8, Poria cocos and Radix Astragali are put into the pulverizer and pulverized, cross a 200 mesh sieve, put the sieved particles into a container, add a 5% hydr...

example 2

[0021]According to percentage by weight, take 40 parts of soybean meal, 15 parts of agar, 8 parts of blood meal, 25 parts of sucrose, 10 parts of sodium chloride solution with a mass fraction of 12%, 1.2 parts of dipotassium hydrogen phosphate and 0.8 parts of potassium dihydrogen phosphate , after stirring evenly, sterilize at 115°C for 30 minutes, adjust the pH to 5.5 with a hydrochloric acid solution with a mass fraction of 10%, and obtain a medium; measure 30mL of the above-prepared medium into a 250mL Erlenmeyer flask, and press solid-liquid Mix the chlortetracycline residue and the glucose solution with a mass fraction of 20% at a ratio of 1:3 and put it in a blender, stir it at 600r / min for 30min and let it stand for 10min, collect 70mL of the supernatant and put it in the Erlenmeyer flask for later use. ; According to the mass ratio of 1:8, Poria cocos and Radix Astragali are put into the pulverizer and pulverized, cross a 200 mesh sieve, put the sieved particles into a...

example 3

[0024] According to percentage by weight, take 50 parts of soybean meal, 13 parts of agar, 6 parts of blood meal, 22 parts of sucrose, 8 parts of sodium chloride solution with a mass fraction of 12%, 0.8 part of dipotassium hydrogen phosphate and 0.2 part of potassium dihydrogen phosphate , after stirring evenly, sterilize at 120°C for 40 minutes, adjust the pH to 6.0 with a 10% hydrochloric acid solution to obtain a medium; measure 40mL of the above-prepared medium into a 250mL Erlenmeyer flask, and press the solid-liquid Mix the chlortetracycline residue and the glucose solution with a mass fraction of 25% at a ratio of 1:3 and put it in a blender, stir it at 800r / min for 40min and let it stand for 15min, collect 90mL of the supernatant and put it in the Erlenmeyer flask for later use. ; According to the mass ratio of 1:8, Poria cocos and Radix Astragali are put into the pulverizer and pulverized, cross a 200 mesh sieve, put the sieved particles into a container, add a 5% hyd...

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Abstract

The invention discloses a method for preparing chlortetracycline hydrochloride and belongs to the field of medicine synthesis. The method aims to solve the problems that at present, a second solvent crystallization method is mostly adopted for producing chlortetracycline hydrochloride in China, the secondary crystallization process is long, much solvent waste liquid is generated by production, and product quality and active ingredients are low. According to the method, strains in aureomycin fungus residues are extracted for culture, then a modified additive solution is utilized to conduct screening modification on cultured strains, meanwhile fermentation is conducted under the acidic condition, the content of aureomycin in the fermentation process is raised so that the aureomycin can be acidized easily, finally adsorption is conducted through attapulgite, the ultrasonic stripping is conducted, concentration and drying are conducted, and the chlortetracycline hydrochloride high in quality and activity is obtained.

Description

technical field [0001] The invention discloses a preparation method of aureomycin hydrochloride, which belongs to the field of drug synthesis. Background technique [0002] Aureomycin is the active ingredient in the biosynthesis of Streptomycesaureofaciens, and it is a tetracycline antibiotic. Chlortetracycline hydrochloride is the hydrochloride salt of chlortetracycline, which is golden yellow or yellow crystal, odorless, bitter in taste, gradually darkens when exposed to light, slightly soluble in water or ethanol, almost soluble in acetone, ether or chloroform It is insoluble. As a human medicine, it is mainly used to treat conjunctivitis and trachoma. As a veterinary medicine, it is mainly used to treat diseases such as typhoid fever and pullorum in livestock and poultry. It can also be used as a growth-stimulating agent for livestock and poultry. In recent years, with the further development of animal husbandry, the market demand for aureomycin hydrochloride has been c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P13/02C07C231/24C07C237/26C12R1/485
CPCC12P29/00C07C231/24
Inventor 汪巍宋国
Owner CHANGZHOU LANXU CHEM CO LTD
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