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Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof

A chlortetracycline hydrochloride, soluble technology, applied in the field of veterinary chlortetracycline hydrochloride soluble powder formulation and preparation field, can solve the problems of chlortetracycline instability, easy oxidation, discoloration, etc., to improve the absorption concentration and prevent oxidation discoloration , the effect of improving stability

Inactive Publication Date: 2015-05-20
PIZHOU ZHENGKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, chlortetracycline hydrochloride soluble powder in the market, because chlortetracycline is unstable, easy to oxidize and change color, has a great influence on the stability and therapeutic effect of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Weigh 10kg of chlortetracycline hydrochloride after sieving, 0.25kg of sodium lauryl sulfate, 0.15kg of disodium ethylenediaminetetraacetic acid, and 84.6kg of anhydrous glucose. The highly efficient and stable veterinary aureomycin hydrochloride soluble powder of the present invention is obtained.

Embodiment 2

[0013] Weigh 15kg of chlortetracycline hydrochloride after sieving, 0.3kg of sodium lauryl sulfate, 0.2kg of disodium ethylenediaminetetraacetic acid, and 84.5kg of anhydrous glucose. The highly efficient and stable veterinary aureomycin hydrochloride soluble powder of the present invention is obtained.

Embodiment 3

[0015] Take by weighing 20kg of chlortetracycline hydrochloride after sieving, 0.5kg of sodium lauryl sulfate, 0.3kg of disodium salt of ethylenediaminetetraacetic acid, and 79.2kg of anhydrous glucose. Efficient and stable veterinary chlortetracycline hydrochloride soluble powder.

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PUM

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Abstract

The invention discloses a formula of veterinary chlortetracycline hydrochloride soluble powder and a preparation method thereof. The soluble powder is prepared from the following components in percentage by weight: 10-50 percent of chlortetracycline hydrochloride, 0.2-3.0 percent of sodium dodecyl sulfate, 0.1-1.0 percent of ethylenediamine tetraacetic acid disodium salt and the balance of glucosum anhydricum. The chlortetracycline hydrochloride is utilized as a raw material, sodium dodecyl sulfate is added as an absorption enhancer, and ethylenediamine tetraacetic acid disodium salt is utilized as an antioxidant and a chelating agent, so that the stability and high efficiency of chlortetracycline hydrochloride soluble powder are ensured.

Description

technical field [0001] The invention relates to a veterinary aureomycin hydrochloride soluble powder formula and a preparation method thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] At present, chlortetracycline hydrochloride soluble powder in the market, because chlortetracycline is unstable, easy to oxidize and change color, has a great influence on the stability and therapeutic effect of the preparation. Contents of the invention [0003] Aiming at the problems existing in the above-mentioned prior art, the present invention provides veterinary aureomycin hydrochloride soluble powder formula and preparation method thereof, which can promote drug absorption and reduce Ca 2+ , Mg 2+ The interference effect of metal ions on the absorption of chlortetracycline can improve the absorption rate and bioavailability of the main drug of chlortetracycline. [0004] In order to achieve the above object, a stable and efficien...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/65A61K47/18A61K47/20A61P31/04
Inventor 王真真田勇李灿王书平张家铭
Owner PIZHOU ZHENGKANG BIOTECH
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