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External traditional Chinese medicine fuming and washing agent for preventing and treating peripheral nerve injury caused by chemotherapy and preparation method of external traditional Chinese medicine fuming and washing agent

A peripheral nerve injury and fumigant technology, which is applied in medical formulas, nervous system diseases, medical preparations containing active ingredients, etc., can solve the problems of limited curative effect and unclear mechanism, and achieve remarkable curative effect, broad market prospects, The effect of increasing the concentration of drug absorption

Inactive Publication Date: 2021-04-23
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of CIPN formation is still unclear. Studies suggest that axonal neuropathy, spinal nerve dorsal root ganglion injury, down-regulation of nerve growth factors, and peripheral immune system lesions are the main pathological mechanisms for the formation of CIPN. Although methylcobalamin and neurotrophic factors are commonly used clinically Drugs such as calcium ion channel modulators and neurotransmitter receptor inhibitors are used to treat CIPN, but the curative effect is limited. At present, there is no prevention and treatment drug with clear curative effect recommended by guidelines and expert consensus

Method used

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  • External traditional Chinese medicine fuming and washing agent for preventing and treating peripheral nerve injury caused by chemotherapy and preparation method of external traditional Chinese medicine fuming and washing agent
  • External traditional Chinese medicine fuming and washing agent for preventing and treating peripheral nerve injury caused by chemotherapy and preparation method of external traditional Chinese medicine fuming and washing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A traditional Chinese medicine fumigation lotion for preventing and treating peripheral nerve damage caused by the chemotherapy drug oxaliplatin, which consists of the following raw materials: 30g of astragalus, 30g of mulberry branch, 15g of cassia twig, 15g of chuanxiong, 6g of scorpion, 9g of aconitum, 9g black, 30g Achyranthes sichuanensis, 15g papaya, 30g stretching grass, 30g Speranthema, 30g Caulis Spatholobus, 15g safflower, 30g mugwort leaves, 15g raw licorice.

[0013] The preparation method of above-mentioned traditional Chinese medicine fumigating lotion is:

[0014] Step 1: Mix the above medicinal materials, add 8 times the weight of water to soak for 2 hours, boil with strong fire, and decoct with slow fire for 30 minutes;

[0015] Step 2: Pour it together with the medicine dregs into the washer (foot bath wooden barrel), mix it with warm water to 4000ml, put the hands and feet on top for fumigation;

[0016] Step 3: Keep the temperature of the medicine a...

Embodiment 2

[0018] A traditional Chinese medicine fumigation lotion for preventing and treating peripheral nerve damage caused by the chemotherapy drug oxaliplatin, which consists of the following raw materials: 40g of astragalus, 15g of mulberry branch, 10g of cassia twig, 10g of chuanxiong, 3g of scorpion, 6g of aconitum, Black 6g, Sichuan Achyranthes bidentata 15g, papaya 10g, 15g skeletal grass, 20g Sperantospermum, 30g Caulis Spatholobus, 10g safflower, 40g mugwort leaves, 30g raw licorice.

[0019] The preparation method of above-mentioned traditional Chinese medicine fumigating lotion is:

[0020] Step 1: Mix the above medicinal materials, add 10 times the weight of water to soak for 2.5 hours, boil with strong fire, and decoct with slow fire for 32 minutes;

[0021] Step 2: Pour it together with the medicine dregs into the washer (foot bath wooden barrel), mix it with warm water to 4000ml, put the hands and feet on top for fumigation;

[0022] Step 3: Keep the temperature of the ...

Embodiment 3

[0024] A traditional Chinese medicine fumigation lotion for preventing and treating peripheral nerve damage caused by the chemotherapy drug oxaliplatin, which consists of the following raw materials: 60g of astragalus, 20g of mulberry branch, 20g of cassia twig, 20g of chuanxiong, 9g of scorpion, 12g of aconitum, 12g black, 25g Achyranthes sichuanensis, 20g papaya, 23g Shenjincao, 15g Sperancus, 30g Caulis Spatholobus, 12g safflower, 60g mugwort leaves, 22g raw licorice.

[0025] The preparation method of above-mentioned traditional Chinese medicine fumigating lotion is:

[0026] Step 1: Mix the above medicinal materials, add 15 times the weight of water to soak for 3 hours, boil with strong fire, and decoct with slow fire for 33 minutes;

[0027] Step 2: Pour it together with the medicine dregs into the washer (foot bath wooden barrel), mix it with warm water to 4000ml, put the hands and feet on top for fumigation;

[0028] Step 3: Keep the temperature of the medicine at a c...

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Abstract

The invention discloses an external traditional Chinese medicine fuming and washing agent for preventing and treating peripheral nerve injury caused by chemotherapy. The external traditional Chinese medicine fuming and washing agent consists of the following traditional Chinese medicine raw materials by weight: 30-60g of astragalus membranaceus, 15-30g of mulberry twigs, 10-20g of cassia twigs, 10-20g of ligusticum wallichii, 3-9g of scorpions, 6-12g of radix aconiti, 6-12g of radix aconiti kusnezoffii, 15-30g of radix cyathulae, 10-20g of pawpaws, 15-30g of herba lycopodii, 15-30g of caulis spatholobi, 30-45g of reticulate millettia, 10-15g of safflower, 30-60g of folium artemisiae argyi and 15-30g of raw liquoric roots. The external traditional Chinese medicine fuming and washing agent adopts an external fuming and washing mode, is simple and convenient to prepare, avoids discomfort of patients caused by oral administration of traditional Chinese medicines, increases the local medicine absorption concentration of lesions, has a more remarkable curative effect, and has the characteristics of no toxicity and long-term use.

Description

technical field [0001] The invention relates to traditional Chinese medicine, in particular to an externally used traditional Chinese medicine fumigation and lotion for preventing and treating peripheral nerve damage caused by chemotherapy and a preparation method thereof. Background technique [0002] Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse reaction in the clinical treatment of malignant tumors, and its incidence accounts for about 60% of chemotherapy patients, seriously affecting the quality of life of patients and the completion of treatment. Common clinical chemotherapy drugs that cause CIPN include platinum, taxanes, vinblastine, and fluorouracil, among which oxaliplatin and paclitaxel cause peripheral nerve injury is the main representative of CIPN, and the incidence of CIPN is as high as 80-90%. . CIPN can be divided into two types: acute and chronic. The clinical manifestations of acute CIPN are mild, and the extremities and / or perioral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/732A61P25/02A61K35/646
CPCA61K9/0014A61K35/646A61K36/11A61K36/185A61K36/21A61K36/236A61K36/282A61K36/286A61K36/47A61K36/481A61K36/484A61K36/486A61K36/54A61K36/605A61K36/714A61K36/732A61K2236/331A61P25/02A61K2300/00
Inventor 康小红曹飞曹向军崔艳慧唐晓男
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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