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Chlortetracycline premix and preparation method thereof

The technology of a premix and chlortetracycline hydrochloride is applied in the direction of pharmaceutical formulations, additional food elements, tetracycline active ingredients, etc. It can solve the problems of easy decomposition, easy generation of dust, and fast release speed, so as to reduce the heat and humidity process and increase production capacity. consumption reduction effect

Active Publication Date: 2013-09-11
JINHE ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional aureomycin premix is ​​prepared by directly spraying and drying the fermentation liquid, and the products formed are mostly powder, which is easy to generate dust when users use it
Moreover, chlortetracycline is easily hydrolyzed in gastric juice, so the traditional chlortetracycline premix releases quickly in gastric juice and is easy to decompose

Method used

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  • Chlortetracycline premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Mix 50Kg aureomycin hydrochloride and 300Kg calcium carbonate ultra-fine powder together (calcium carbonate can pass through 800 mesh sieve), mix the mixed powder with 60Kg corn starch, 15Kg microcrystalline cellulose, 45Kg dextrin, 25Kg polyacrylic acid Resin powder (weight ratio, polyacrylic resin No. II: polyacrylic resin No. III = 3:2) was stirred for 30 minutes, and the mixture was compressed into tablets by a tablet machine. Then it is pulverized and sieved by a pulverizer, wherein the particles that have not passed through the 20 mesh sieve continue to be crushed, and the particles smaller than the 60 mesh sieve are returned to tableting. The remaining 20-mesh sieve but not 30-mesh sieve particles and the 30-mesh sieve but not 60-mesh sieve particles are required finished products, and the product 455Kg is obtained, and the first-time yield is 91%.

[0026] Get a sample detection content by interval 70kg from present embodiment, content detection result is as fol...

Embodiment 2

[0029] Mix 100Kg aureomycin hydrochloride and 250Kg calcium carbonate fine powder together (calcium carbonate can pass through 800 mesh sieve), mix the mixed powder with 75Kg corn starch, 25Kg microcrystalline cellulose, 50Kg dextrin, 25Kg polyacrylic acid Resin powder (weight ratio, polyacrylic resin No. II: polyacrylic resin No. III = 3:2) was stirred for 30 minutes, and the mixture was compressed into tablets by a tablet machine. Then it is pulverized and sieved by a pulverizer, wherein the particles that have not passed through the 20 mesh sieve continue to be crushed, and the particles smaller than the 60 mesh sieve are returned to tableting. Remaining 20-mesh sieve but not 30-mesh sieve particles and 30-mesh sieve-less 60-mesh sieve particles are the desired finished products, and the product 431Kg is obtained, and the primary yield is 86.2%.

[0030] Get a sample detection content by interval 70kg from present embodiment, content detection result is as following table: ...

Embodiment 3

[0033] Mix 50Kg aureomycin hydrochloride and 300Kg calcium carbonate fine powder together (calcium carbonate can pass through 800 mesh sieve), mix the powder after mixing with 60Kg cornstarch, 60Kg dextrin, 25Kg polyacrylic acid resin powder (weight ratio, Polyacrylic resin No. II: Polyacrylic resin No. III = 1:1) After stirring for 30 minutes, the mixture was compressed into tablets by a tablet machine. Then it is pulverized and sieved by a pulverizer, wherein the particles that have not passed through the 20 mesh sieve continue to be crushed, and the particles smaller than the 60 mesh sieve are returned to tableting. Remaining 20-mesh sieve but not 30-mesh sieve particles and 30-mesh sieve-less 60-mesh sieve particles are required finished products, and the product 407Kg is obtained, and the first-time yield is 81.4%.

[0034] Get a sample detection content by interval 70kg from present embodiment, content detection result is as following table:

[0035] Sample ser...

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Abstract

The invention provides a chlortetracycline premix and a preparation method thereof. By weight, the premix contains 10-20 parts of chlortetracycline hydrochloride, 50-60 parts of calcium carbonate, 10-30 parts of corn starch, 10-15 parts of an adhesive, and 5-10 parts of enteric polyacrylic resin, wherein the adhesive is microcrystalline cellulose and / or dextrin. The prescription of the chlortetracycline premix provided in the invention is more suitable for a dry granulation process, can significantly improve one-time yield and increase product fluidity and slow release property, thus solving the difficulties of a dry granulation process of the chlortetracycline premix. During mass production, the chlortetracycline hydrochloride premix can achieve good uniformity, and generates less dust. In addition, the premix can guarantee that the chlortetracycline hydrochloride is incompletely released in gastric juice, thus enhancing the utilization degree of chlortetracycline hydrochloride.

Description

technical field [0001] The invention belongs to the field of feed additives, and relates to a chlortetracycline premix and a preparation method thereof, in particular to a chlortetracycline premix suitable for dry granulation preparation and a preparation method thereof. Background technique [0002] Tetracyclines are named after the chemical structure of tetracene mother nucleus, and Chlortetracycline, also known as chlorotetracycline, is a kind of tetracycline derivatives, which mainly inhibits the protein synthesis of sensitive microorganisms. Chlortetracycline has a broad antibacterial spectrum, and can inhibit Gram-positive bacteria, negative bacteria, spirochetes, rickettsia, mycoplasma, chlamydia, and some protozoa. [0003] Chlortetracycline is used in feedstuffs at a preventive dose (50-75mg / kg) in livestock and poultry production at home and abroad, with the purpose of promoting the growth of livestock and poultry. Adding chlortetracycline to pig rations can impro...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/65A61K47/32A61K47/04A61P31/04A61P33/02A23K1/17A23K20/195
Inventor 路赟李荣顺
Owner JINHE ANIMAL PHARMA
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