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Veterinary-use intestinal targeted antibacterial pellet and preparation method thereof

A technology of targeting and pellets, which is applied in the field of veterinary intestinal targeting antibacterial pellets and its preparation, antibacterial drugs for animals and its preparation, and can solve the problems of low drug concentration, narrow antibacterial spectrum of warnimulin, and bioavailability Low-level problems, to achieve the effect of easy operation, increase blood concentration and bioavailability, and ensure therapeutic effect

Active Publication Date: 2012-07-25
山东胜利生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Non-targeted salnemulin is basically absorbed in the stomach and duodenum, with a significant first-pass hepatoenteric effect and low bioavailability; Lawsonia intracellulare, Treponema, Brachyspira coli and Mycoplasma hyopneumoniae It mainly parasitizes in the ileum, ileocecal junction, colon and lungs, where the drug concentration of warnemulin is low; in addition, the antibacterial spectrum of warnemulin is relatively narrow

Method used

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  • Veterinary-use intestinal targeted antibacterial pellet and preparation method thereof
  • Veterinary-use intestinal targeted antibacterial pellet and preparation method thereof
  • Veterinary-use intestinal targeted antibacterial pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] According to the technical scheme of the present invention, micropills are prepared, and the content of warnemulin hydrochloride in the micropills is 5wt%, and the consumption relation of principal agent and auxiliary material is shown in the following table, and described auxiliary material refers to the removal of warnemulin hydrochloride and hydrochloric acid Ingredients contained in Chlortetracycline outer pellets (such as fillers, disintegrants, binders, etc.):

[0032]

[0033] The micropills of the present invention are composed of a core of Vermicola hydrochloride (abbreviated as core, the same below), an intestinal targeting coating layer, a chlortetracycline hydrochloride drug layer and an outer coating layer. Lin, which is coated with an intestinal-targeting coating layer, which contains a polypropylene resin intestinal-targeting coating material (also called an intestinal-targeting coating material), which can make the main drug fertilin hydrochloride The t...

Embodiment 2

[0050] According to the technical scheme of the present invention, micropills are prepared, and the content of warnemulin hydrochloride in the micropills is 5wt%, and the consumption relation of principal agent and auxiliary material is shown in the following table, and described auxiliary material refers to the removal of warnemulin hydrochloride and hydrochloric acid Ingredients contained in Chlortetracycline outer pellets (such as fillers, disintegrants, binders, etc.):

[0051]

[0052] In the pellets, the content percentages of the components in the pellet core, the intestinal targeting coating layer, the aureomycin hydrochloride drug layer and the outer coating layer are the same as in Example 1, and the preparation method is also the same as in Example 1.

[0053] Three batches of micropills with different components in the above Example 2 were respectively tested for drug release according to the method specified in Veterinary Pharmacopoeia (2010). Six samples were m...

Embodiment 3

[0055] According to the technical scheme of the present invention, micropills are prepared, and the content of warnemulin hydrochloride in the micropills is 1wt%, and the consumption relation of principal agent and adjuvant is shown in the table below, and described adjuvant refers to the removal of warnemuline hydrochloride and hydrochloric acid Ingredients contained in Chlortetracycline outer pellets (such as fillers, disintegrants, binders, etc.):

[0056]

[0057] In the pellets, the content percentages of the components in the pellet core, the intestinal targeting coating layer, the aureomycin hydrochloride drug layer and the outer coating layer are the same as in Example 1, and the preparation method is also the same as in Example 1.

[0058] Three batches of micropills with different components in the above Example 3 were tested for drug release according to the method specified in Veterinary Pharmacopoeia (2010). Six samples were made in parallel for each batch of mi...

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Abstract

The invention discloses a veterinary-use intestinal targeted antibacterial pellet. The veterinary-use intestinal targeted antibacterial pellet comprises a main drug and auxiliary drugs, wherein the main drug is composed of valnemulin hydrochloride and chlortetracycline hydrochloride; the mass of the valnemulin hydrochloride is 1-5% of that of the pellet; the mass of the chlortetracycline hydrochloride is 5-16 times of that of the valnemulin hydrochloride; the pellet sequentially comprises a valnemulin hydrochloride core, an intestinal targeted coating layer, a chlortetracycline hydrochloride drug layer and an outer coating layer from inside to outside. The invention further discloses a preparation method of the veterinary-use intestinal targeted antibacterial pellet. Through the combination of the method and the formula, the valnemulin hydrochloride and the chlortetracycline hydrochloride are adopted for preparing the pellet; the pellet is released in a gradient form in an animal digestion system; the chlortetracycline hydrochloride is firstly released and absorbed by the stomach and the intestine; the valnemulin hydrochloride is rapidly released and absorbed by the intestinal tract with the pH value larger than or equal to 6.8, so that an excellent intestinal tract sterilization effect is achieved, the drug absorbed by the colon can be prevented from suffering from the first-pass effect of the liver and the intestine, the haemoconcentration and bioavailability of the valnemulin hydrochloride can be improved, and an excellent treatment effect for systemic diseases is obtained.

Description

Technical field [0001] The present invention involves a antibacterial drug and its preparation method. It specifically involves a beast intestinal targeting antibacterial microne pills and its preparation methods, which belongs to the field of veterinary drug technology. Background technique [0002] Valnemulin (Valnemulin) is a new generation of Pleuromutilin semi -synthetic antibiotics, which belongs to the same type of drugs as Thai Miaoxin, and is an animal -specific antibiotic.Magic Miaolin antibacterial spectrum is wide, to G to G + G - Both and mycoplasma are used to prevent and treat the dysentery of dysentery caused by the short spiral body caused by pig dysentery, pneumonia, pneumonia, pneumonia, and colonbococcal -like short spiral body.Sexual recovery, chronic respiratory diseases caused by bird losing blood branch, is caused by multi -killer Patto, pleuric bacteria, and secondary pneumonia caused by Perisalobacteria, and hemolytic Bacteria.Pneumonia, pneumonia, polyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K31/22A61K9/16A61P31/04
Inventor 马景武李明赵才兵王永恒张旭王炜
Owner 山东胜利生物工程有限公司
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