Method for preparing standard substance for detecting antibiotics in cosmetics

A standard substance and preparation method technology, applied in cosmetic preparations, dressing preparations, pharmaceutical formulations, etc., can solve problems affecting the accuracy of detection and achieve accurate detection results

Active Publication Date: 2012-02-01
SHANGHAI INST OF MEASUREMENT & TESTING TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] The detection of antibiotics in cosmetics is one of the important guarantees for the safety of cosmetics. At present, direct compound detection methods are mostly used. However, in practical applications, after the antibiotics in cosmetics are mixed with the ingredients of the formula, the detection will be compared with the direct use of compounds. There is a big difference in the detection, which will affect the accuracy of the detection

Method used

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  • Method for preparing standard substance for detecting antibiotics in cosmetics
  • Method for preparing standard substance for detecting antibiotics in cosmetics
  • Method for preparing standard substance for detecting antibiotics in cosmetics

Examples

Experimental program
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Effect test

Embodiment 1

[0034] According to the formula and preparation process in the table, it is formulated into a cosmetic cream. Prepare the antibiotic chloramphenicol into 0.5g / 100mL aqueous solution or propylene glycol solution, and then slowly add the aqueous solution or propylene glycol solution containing the antibiotic chloramphenicol to the cosmetic cream, and make the final concentration of chloramphenicol in the standard substance reach 0.1g / 100mL, keep the temperature constant at about 20°C and slowly stir evenly under the conditions of minimum water evaporation, and dispense.

[0035] The purity of chloramphenicol is ≥98%, provided by Sigma-Aldrich Shanghai Trading Co., Ltd.

Embodiment 2

[0037] According to the formula and preparation process in the table, it is formulated into a cosmetic cream. Prepare the antibiotic minocycline hydrochloride into 0.5g / 100mL aqueous solution or propylene glycol solution, then slowly add the aqueous solution or propylene glycol solution containing the antibiotic minocycline hydrochloride to the cosmetic cream, and make the minocycline hydrochloride in the standard substance The final concentration reaches 0.1g / 100mL, keep the temperature constant at about 20°C and slowly stir evenly under the conditions of minimum water evaporation, and dispense.

[0038] The purity of minocycline hydrochloride>99.0% was provided by Sigma-Aldrich Shanghai Trading Co., Ltd.

Embodiment 3

[0040] According to the formula and preparation process in the table, it is formulated into a cosmetic cream. The antibiotic oxytetracycline dihydrate is prepared into 0.5g / 100mL aqueous solution or propylene glycol solution, and then the aqueous solution or propylene glycol solution containing the antibiotic oxytetracycline dihydrate is slowly added to the cosmetic cream, and the oxytetracycline dihydrate in the standard substance The final concentration reaches 0.1g / 100mL, keep the temperature constant at about 20°C and slowly stir evenly under the conditions of minimum water evaporation, and dispense.

[0041] The purity of oxytetracycline dihydrate>99.0%, provided by Sigma-Aldrich Shanghai Trading Co., Ltd.

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Abstract

The invention relates to a method for preparing a standard substance for detecting antibiotics in cosmetics. The standard substance is formed by mixing aqueous solution of the antibiotics or solution of propylene glycol and cosmetic cream, wherein the cosmetic cream comprises the following components in percentage by weight: 73 to 78 percent of de-ionized water, 3 to 3.5 percent of propylene glycol and 0.2 to 0.25 percent of carbomer in phase A, 4.5 to 5 percent of stearate, 3 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of 26# white oil in phase B and 1.2 to 1.25 percent of phenoxyethanol and ethylhexylglycerin in phase C; and the concentration of the antibiotics in the standard substance reaches 0.1g / 100ml. The method has the advantages that: the antibiotics and the cosmetic cream are mixed to form the standard substance for detecting the antibiotics such as minocycline hydrochloride, oxytetracycline dehydrate, tetracycline hydrochloride, chlortetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol in the cosmetic; and the standard substance is the same as a sample of the cosmetic containing the antibiotics in the actual use; thus the detection of the antibiotics in the cosmetic conforms to the state of the actual application better and is more accurate.

Description

Technical field [0001] The invention relates to the field of cosmetics detection, in particular to a method for preparing standard substances for detecting antibiotics in cosmetics. Background technique [0002] The detection of antibiotics in cosmetics is one of the important safeguards for the safety of cosmetics. At present, more direct compound detection methods are used. However, in practical applications, the antibiotics in the cosmetics are mixed with the ingredients of the formula and then tested with the direct use of the compound. There are big differences in detection, which will affect the accuracy of detection. Compared with standard compounds, cosmetic standard substances not only have accurate measurement standards, but also have one or more sufficiently uniform and well-determined characteristic values, with traceability of the value, which is useful for improving cosmetic production, The detection level of cosmetics inspection, uniform measurement values, evalua...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/02A61K8/06A61K8/42
Inventor 陈黎明胡国胜
Owner SHANGHAI INST OF MEASUREMENT & TESTING TECH
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