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Chlortetracycline hydrochloride dry suspension as well as preparation method and application thereof

A technology of chlortetracycline hydrochloride and dry suspension is applied in the field of chlortetracycline hydrochloride dry suspension and its preparation, and achieves the effects of good clinical effect, good palatability and improved bioavailability

Pending Publication Date: 2022-03-01
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant report on aureomycin hydrochloride dry suspension preparation in China

Method used

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  • Chlortetracycline hydrochloride dry suspension as well as preparation method and application thereof
  • Chlortetracycline hydrochloride dry suspension as well as preparation method and application thereof
  • Chlortetracycline hydrochloride dry suspension as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Suspension formulation screening:

[0040] 1. Orthogonal experimental design

[0041] 1.1 Instruments: electronic balance (sensitivity 0.001g), water bath, digital high-speed dispersion homogenizer, beaker, 100ml measuring cylinder.

[0042] 1.2 Raw materials: aureomycin hydrochloride, xanthan gum, crospovidone, hydroxypropyl methylcellulose, ethyl vanillin, citric acid.

[0043] 1.3 Method: Accurately weigh 22g of aureomycin hydrochloride crushed through a 200-mesh sieve, put it in a 1000ml beaker, then add suspending agent, 5g of citric acid, 0.5g of ethyl vanillin, and purified water 500ml. Put the beaker into a water bath, and process it with a digital display high-speed dispersing homogenizer for 30 minutes, maintaining the temperature of the suspension in the beaker at 40°C.

[0044] 1.4 Orthogonal test design: On the basis of searching literature and previous preliminary tests, an orthogonal test was carried out with xanthan gum, crospovidone, hydroxypropyl me...

Embodiment 2

[0054]

[0055] The preparation method is as follows:

[0056] Aureomycin hydrochloride is pulverized with a pin-disc pulverizer, and passed through a 200 mesh sieve; the remaining auxiliary materials are respectively passed through a 120 mesh sieve;

[0057] Weigh aureomycin hydrochloride, xanthan gum, polyvinylpyrrolidone K30, hydroxypropyl methylcellulose, and citric acid according to the proportion and put them into the stirring tank with vacuum, add ethyl vanillin directly at the gate, and start the stirring tank Stir the motor, add 500L of purified water, and then start the upper and lower suction high-shear emulsifiers, throttling upper suction emulsifiers, keep the tank temperature at 35-40°C, high-speed shear, and disperse for 30 minutes to form a suspension;

[0058] Spray-dry the suspension to make fine particles and pass through an 80-mesh sieve. The spray drying air inlet temperature is controlled at 120°C, and the outlet air temperature is controlled at 80°C;...

Embodiment 3

[0061]

[0062] The preparation method is as follows:

[0063] Aureomycin hydrochloride is pulverized with a pin-disc pulverizer, and passed through a 200 mesh sieve; the remaining auxiliary materials are respectively passed through a 120 mesh sieve;

[0064] Weigh aureomycin hydrochloride, xanthan gum, polyvinylpyrrolidone K30, hydroxypropyl methylcellulose, and citric acid according to the proportion and put them into the stirring tank with vacuum, add ethyl vanillin directly at the gate, and start the stirring tank Stir the motor, add 500L of purified water, and then start the upper and lower suction high-shear emulsifiers, throttling upper suction emulsifiers, keep the tank temperature at 35-40°C, high-speed shear, and disperse for 30 minutes to form a suspension;

[0065] Spray-dry the suspension to make fine particles and pass through an 80-mesh sieve. The spray drying air inlet temperature is controlled at 120°C, and the outlet air temperature is controlled at 80°C;...

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Abstract

The invention relates to a chlortetracycline hydrochloride dry suspension as well as a preparation method and application thereof, and the chlortetracycline hydrochloride dry suspension comprises the following raw materials in percentage by mass: 15-35% of chlortetracycline hydrochloride, 1-15% of a suspending aid, 1-5% of a pH value regulator, 0.1-1% of a flavoring agent and 44.9-82.9% of a filler. The method comprises the following steps: S1, crushing and sieving chlortetracycline hydrochloride; s2, sieving other auxiliary materials; s3, weighing the chlortetracycline hydrochloride, the suspending aid, the pH value adjusting agent and the flavoring agent according to the proportion, feeding the materials into a stirring tank in vacuum, and adding a proper amount of purified water to form a suspension; s4, carrying out spray drying on the suspension, and sieving with a 80-mesh sieve; and S5, uniformly mixing the product obtained by spraying with a filling agent in a mixing machine to obtain the chlortetracycline hydrochloride dry suspension. The product disclosed by the invention is acidic and can be used together with drugs which have synergistic interaction with chlortetracycline hydrochloride, the palatability of an aqueous solution is good, and clinical test results show that the product disclosed by the invention improves the clinical effect and the blood concentration of chlortetracycline hydrochloride.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a dry suspension of aureomycin hydrochloride and its preparation method and application. Background technique [0002] Aureomycin hydrochloride is the active ingredient in the biosynthesis of Streptomycos aurcofacions, and it is a tetracyclic antibiotic. Chlortetracycline hydrochloride is the hydrochloride salt of chlortetracycline, which is golden yellow or yellow crystal, odorless, bitter in taste, gradually darkens when exposed to light, slightly soluble in water or ethanol, almost soluble in acetone, ether or chloroform insoluble. The extraction process of aureomycin hydrochloride is acidification and filtration of fermentation broth, precipitation, coarse crystallization and filtration, extraction, crystallization and washing, drying and mixing. [0003] As a basic veterinary chemical, aureomycin hydrochloride plays an important role in the development of anima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/65A61K47/38A61K47/36A61K47/32A61P31/04
CPCA61K9/146A61K31/65A61P31/04
Inventor 李荣顺王志军方军秦斌周建
Owner 金河牧星(重庆)生物科技有限公司
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