Marbofloxacin flavored tablets and preparation method therefor

A marbofloxacin and flavor technology, applied in the field of medicine, can solve the problems of no flavoring agent, inconvenient use, pet bites, etc., and achieve the effects of good palatability, saving production costs, and high repetition rate

A marbofloxacin and flavor technology, applied in the field of medicine, can solve the problems of no flavoring agent, inconvenient use, pet bites, etc., and achieve the effects of good palatability, saving production costs, and high repetition rate

CN112089696APending Publication Date: 2020-12-18上海信元动物药品有限公司
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This example relates to a marbofloxacin flavor tablet, including the following components in parts by weight: 5 parts of marbofloxacin, 83.1 parts of filler, 10 parts of disintegrating agent, 1.8 parts of lubricant, and 0.1 part of flavoring agent .

[0026] The filler is composed of 58.1% microcrystalline cellulose, 5% lactose, 10% compressible starch and 10% glucose in terms of the total weight percentage of flavor tablet raw materials.

[0027] The disintegrant is croscarmellose sodium, which can effectively improve the dispersibility of marbofloxacin.

[0028] The lubricant is colloidal silicon dioxide, which effectively increases the fluidity of the powder and improves the stability of tablet forming.

[0029] The flavoring agent is milk flavoring, which can make the flavoring tablet more suitable for oral medicine for pets.

[0030] Also relate to the preparation method of aforementioned marbofloxacin flavor tablet, described method comprises the steps:

[0031...

Embodiment 2

[0038] This embodiment relates to marbofloxacin flavored tablets, including the following components in parts by weight:

[0039] 8 parts of marbofloxacin, 82.15 parts of filler, 8 parts of disintegrant, 1.8 parts of lubricant, and 0.05 part of flavoring agent.

[0040] The filler is composed of 57.15% of microcrystalline cellulose, 5% of lactose, 10% of compressible starch and 10% of glucose in terms of the total weight percentage of flavor tablet raw materials.

[0041] The disintegrant is bolus-type sodium carboxymethyl starch, which can effectively improve the dispersibility of marbofloxacin.

[0042] The lubricant is magnesium stearate and silicon dioxide mixed in a mass ratio of 1:1. Effectively increase the fluidity of the powder and improve the stability of tablet molding.

[0043] The flavoring agent is peppermint flavoring, which can make the flavoring tablet more suitable for oral medicine for pets.

[0044] Also relate to the preparation method of aforementioned...

Embodiment 3

[0050] This example relates to marbofloxacin flavored tablets, including the following components in parts by weight: 6 parts of marbofloxacin, 82.15 parts of filler, 10 parts of disintegrant, 1.8 parts of lubricant, and 0.05 part of flavoring agent.

[0051] The filler is composed of 57.15% of microcrystalline cellulose, 5% of lactose, 10% of compressible starch and 10% of glucose in terms of the total weight percentage of flavor tablet raw materials.

[0052] The disintegrant is croscarmellose sodium, which can effectively improve the dispersibility of marbofloxacin.

[0053] The lubricant is magnesium stearate, which effectively increases the fluidity of the powder and improves the stability of tablet molding.

[0054] The flavor agent is chicken flavor, which can make the flavor tablet more suitable for oral medicine for pets.

[0055] Also relate to the preparation method of aforementioned marbofloxacin flavor tablet, described method comprises the steps:

[0056] Step ...

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Abstract

The invention provides marbofloxacin flavored tablets and a preparation method therefor. The marbofloxacin flavored tablets comprise the following ingredients in parts by weight: 4-18 parts of marbofloxacin, 50-83.1 parts of filler, 5-30 parts of disintegrant, 0.1-2 parts of lubricant and 0.05-5 parts of flavoring agent. The invention further relates to the preparation method for the marbofloxacinflavored tablets. According to the method provided by the invention, the marbofloxacin is adopted as an effective pharmaceutical ingredient of the oral-administration flavored tablets, and the existing formula is optimized; and thus, the oral-administration flavored tablets prepared by the method can have the following advantages that the palatability is better, the administration is convenient,and the oral-administration flavored tablets can serve as an oral-administration drug for treating deep and shallow skin infection, respiratory tract infection and urinary tract infection of a pet.

Description

technical field [0001] The invention belongs to the field of medicine; in particular, it relates to a flavored marbofloxacin tablet and a preparation method thereof. Background technique [0002] Marbofloxacin is a new type of fluoroquinolone antibacterial drug for animals. Its chemical name is 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)- 7-Oxo-7H-pyridine-[3,2,1-i j](4,1,2)benzoxadiazine-6-carboxylic acid, its mechanism of action is to inhibit bacterial DNA transcriptase thereby inhibiting bacterial Growth, antibacterial effect on Gram-negative bacteria, Gram-positive bacteria and mycoplasma. Marbofloxacin can be well absorbed through injection and has low toxicity and side effects, and it is increasingly used to treat deep and superficial skin infections, respiratory tract infections, and urinary tract infections in pets. However, due to the troublesome operation of traditional injection administration, the emergency is relatively large, and most of the mar...

Claims

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Application Information

Patent Timeline
18 Dec 2020
Publication
CN112089696A
IPC
A61K9/20; A61K47/38; A61K47/04; A61K47/46; A61K47/36; A61K47/12; A61K31/5395; A61P31/04; A61P17/00; A61P11/00; A61P13/02
CPC
A61K9/2095; A61K9/2054; A61K9/2009; A61K9/2068; A61K9/2059; A61K9/2013; A61K31/5395; A61P31/04
Inventors
施军辉; 施柔安