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36results about How to "Improve disintegration time limit" patented technology
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Oral quick-dissolving film preparation and preparation method thereof
InactiveCN102824333AImprove disintegration time limitSolve the shortcomings of taking waterPharmaceutical non-active ingredientsSexual disorderVardenafilTadalafil
The invention discloses an oral quick-dissolving film preparation and a preparation method thereof. The oral quick-dissolving film comprises the following components in percentage by weight: 20 to 40 percent of medicinal active component, 40 to 75 percent of water-soluble film forming material, 10 to 25 percent of plasticizer, 0 to 25 percent of disintegrating agent, and 0.1 to 8 percent of water, wherein the medicinal active component is one of sildenafil, tadalafil, vardenafil or salts thereof. According to the oral quick-dissolving film preparation, the disintegration time limited of the film preparation can be remarkably accelerated, the problem that most oral solid preparations should be taken with water can be solved, medicine taking time cannot be delayed under a condition without water, and the taking compliance of a patient can be improved.
Owner:SUZHOU UNIV
Povidone iodine effervescent tablets with anti-microbial, skin-care and anti-inflammation functions and production process of povidone iodine effervescent tablets
InactiveCN105640916ASolve the shortcomings of strong irritationSimplify using stimuliAntisepticsPill deliveryPolyethylene oxideIrritation
The invention relates to povidone iodine effervescent tablets with anti-microbial, skin-care and anti-inflammation functions and a production process of the povidone iodine effervescent tablets. The effervescent tablets comprise 10%-15% of povidone iodine, 51%-80% of an effervescent disintegrating agent, 1%-5.5% of a tablet disintegrating agent, 1.3%-5% of a compound polymer synergist, 0.01%-0.1% of zinc oxide, 0.05%-0.5% of dextrin, 0.5%-5% of polyethylene oxide, 0.1%-5% of a lubricant and the balance of filler. According to the effervescent tablets, a medicine integrating anti-microbial, anti-inflammation and skin-care functions and having complete functions is developed by carefully studying the function mechanism of medicines after multiple experiments, the anti-inflammation function is realized in the disinfection process, and the medicine administration step is simplified in the medical process. Besides, pain of a patient in the medicine use process is relieved, and detection shows that the irritation of the effervescent tablets in the formula is extremely small and is much lower than that of like products. The preparation process is simple and convenient to operate, the equipment is simple, and the product is convenient to use, transport and carry and suitable for industrial large-scale popularization and use.
Owner:SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
Traditional Chinese medicine soft capsule auxiliary material with universality and method for preparing traditional Chinese medicine soft capsules
InactiveCN104383551AIncrease the proportionReduce dosageCapsule deliveryOil/fats/waxes non-active ingredientsPharmaceutical drugEngineering
The invention relates to a traditional Chinese medicine soft capsule forming core technology with universality and a traditional Chinese medicine soft capsule forming core process with universality. The process consists of the following technologies: preparing the content and emulsifying, preparing a capsule wall material and melting, pressing and forming, and drying. The process comprises the following three aspects: 1, a mixed emulsifier used for the traditional Chinese medicine soft capsules and a preparation method thereof; 2, a capsule wall material formula used for the traditional Chinese medicine soft capsules and a preparation method thereof; and 3, technical parameters for pre-drying and final drying in the method for preparing the traditional Chinese medicine soft capsules. The application research proves that the application range of the traditional Chinese medicine soft capsules is widened; the specific gravity of the drug effect material is improved, and the amount of auxiliary materials is reduced; the drug stability is high, and phenomena of layering, leakage, deformation and transfer are avoided; the difference control level of the device is improved; and the disintegration time limit prolonging is effectively controlled.
Owner:山西黄河中医药研究所(有限公司)
Rapidly disintegrable Zhenju antihypertensive tablets and preparation method thereof
ActiveCN101829175AImprove disintegration time limitHigh dissolution rateOrganic active ingredientsPharmaceutical non-active ingredientsCarboxymethyl starchCross-link
The invention discloses rapidly disintegrable Zhenju antihypertensive tablets and a preparation method thereof, which are used for solving the problems that the conventional Zhenju antihypertensive tablets are unstable in uniformity and slow in disintegration and absorption, and the like. The rapidly disintegrable Zhenju antihypertensive tablets are characterized by comprising 70 to 90 percent of principal drug, 5 to 15 percent of disintegrating agent, 10 to 20 percent of thinning agent, 1 to 3 percent of lubricating agent, 3 to 8 percent of coating agent, and the balance of wetting agent, wherein the disintegrating agent comprises carboxymethyl starch sodium, cross-linked polyvinylpyrrolidone and lauryl sodium sulfate which are used together, and the weight ratio of the three is (8 to 15):(8 to 15):(1 to 3), wherein the lauryl sodium sulfate is used as an external disintegrating agent; the carboxymethyl starch sodium is used as an internal and external disintegrating agent, and the weight ratio of the internal addition to the external addition is 2:1; and the cross-linked polyvinylpyrrolidone is used as an internal and external disintegrating agent, and the weight ratio of the internal addition to the external addition is 4:1. The exploration on the selection, using method and dosage of auxiliary materials is carried out, the uniformity and controllability of product quality are ensured, and the rapidly disintegrable Zhenju antihypertensive tablets have the advantages of uniform dispersion and rapid disintegration.
Owner:浙江得恩德制药股份有限公司
Traditional Chinese medicinal composition for treating gouts, and preparation and preparation method thereof
InactiveCN105998563AWell mixedGood treatment effectSkeletal disorderPill deliverySide effectTherapeutic effect
The invention provides a traditional Chinese medicine composition for treating gout and its preparation and preparation method. The traditional Chinese medicine composition is prepared from the following ingredients in parts by mass: 3-5 parts of trillium chinensis, 8-12 parts of sea cucumber, 1-3 parts of sea urchin extract, 8-12 parts of astragalus, 4-8 parts of Ganoderma lucidum, 1-5 parts of Moringa leaf, 3-7 parts of knotweed, 1-5 parts of celery seed, 4-8 parts of radish, gardenia 3 to 7 parts of fennel, 4 to 8 parts of Banfenghe, and 3 to 7 parts of moxibustion licorice. The preparation for treating gout provided by the invention has a good therapeutic effect on gout; the effective rate reaches 96.7%, the side effects are small, and the types of raw materials used are few, and the purpose of complementing each other and synergistically exerting the curative effect of each raw material of traditional Chinese medicines can be realized; After being made into tablets, it is more convenient to take and carry, and can give full play to the curative effect of the traditional Chinese medicine composition. The formulation of the preparation has the effects of clearing heat and detoxifying, promoting dampness and relieving pain, nourishing the spleen and kidney, regulating body fluid metabolism, etc., and has remarkable curative effect on gout.
Owner:北京壹桥健康科技有限公司
Preparing method of Shiwuwei Longdanhua pill
InactiveCN106728424AShorten drying timeThe solution is not easy to disintegratePill deliveryRespiratory disorderMedicineDrying time
The invention relates to a preparing method of Shiwuwei Longdanhua pills. The method is characterized by comprising the steps of firstly evenly wetting prepared Shiwuwei Longdanhua pill pellets with purified water, adding Shiwuwei Longdanhua pill raw powder and performing round rolling, then putting the Shiwuwei Longdanhua pill pellets into a boiling drying granulator to conduct primary drying, afterwards performing screening, supplementing powder with the Shiwuwei Longdanhua pill raw powder, conduct secondary drying in the boiling drying granulator, finally capping the pellets after secondary drying with the purified water, and only conducting tertiary drying in the boiling drying granulator. According to the preparing method of the Shiwuwei Longdanhua pills, a method of boiling drying is adopted to replace heat-wind circulating drying, accordingly the problems that the pellet drying time is long, the pellets are not easy to disintegrate and the appearance shape is not good are effectively solved, the pellet drying time can be reduced to about 20 h, meanwhile stability of Shiwuwei Longdanhua pill product is effectively improved, and further the product quality is improved; the produced pills are easy to disintegrate and thus convenient to take, the color and luster of the pellets are consistent, and the appearance shape is uniform.
Owner:NINGXIA DUOWEI PHARMA
Capsule for treating urinary system diseases and preparation method thereof
ActiveCN102846802AGood treatment effectQuality is easy to controlUrinary disorderCapsule deliveryUrinary systemDiuresis
The invention relates to a capsule for treating urinary system diseases and a preparation method thereof. The capsule is a traditional Chinese medicine capsule for treating urinary system infection and inflammations. The preparation method comprises that 30 to 50 parts by mass of Polygonum capitatum D.Don, 20 to 40 parts by mass of all-grass of maidenhair, 10 to 20 parts by mass of amur corktree bark and 4 to 6 parts by mass of auxiliary materials are orderly subjected to extraction, drying, crushing, blending and filling. The capsule for treating urinary system diseases has the effects of clearing away heat and purging pathogenic fire, alleviating water retention and treating stranguria, diminishing inflammation and swelling, and eliminating dampness and inducing diuresis, has good treatment effects on urinary system infection and inflammations caused by stagnation of dampness-heat, is safe and effective, has controllable quality, avoids repeated attack, has no obvious toxic and side effects, does not cause drug resistance, and has a low cost and a high clinical popularization value.
Owner:贵州弘泽制药有限公司
Rapidly disintegrable Zhenju antihypertensive tablets and preparation method thereof
ActiveCN101829175BImprove disintegration time limitHigh dissolution rateOrganic active ingredientsPharmaceutical non-active ingredientsCarboxymethyl starchCross-link
The invention discloses rapidly disintegrable Zhenju antihypertensive tablets and a preparation method thereof, which are used for solving the problems that the conventional Zhenju antihypertensive tablets are unstable in uniformity and slow in disintegration and absorption, and the like. The rapidly disintegrable Zhenju antihypertensive tablets are characterized by comprising 70 to 90 percent ofprincipal drug, 5 to 15 percent of disintegrating agent, 10 to 20 percent of thinning agent, 1 to 3 percent of lubricating agent, 3 to 8 percent of coating agent, and the balance of wetting agent, wherein the disintegrating agent comprises carboxymethyl starch sodium, cross-linked polyvinylpyrrolidone and lauryl sodium sulfate which are used together, and the weight ratio of the three is (8 to 15):(8 to 15):(1 to 3), wherein the lauryl sodium sulfate is used as an external disintegrating agent; the carboxymethyl starch sodium is used as an internal and external disintegrating agent, and the weight ratio of the internal addition to the external addition is 2:1; and the cross-linked polyvinylpyrrolidone is used as an internal and external disintegrating agent, and the weight ratio of the internal addition to the external addition is 4:1. The exploration on the selection, using method and dosage of auxiliary materials is carried out, the uniformity and controllability of product quality are ensured, and the rapidly disintegrable Zhenju antihypertensive tablets have the advantages of uniform dispersion and rapid disintegration.
Owner:浙江得恩德制药股份有限公司
Soft capsule shell composition, soft capsule, and preparation and application thereof
InactiveCN108785269AImprove disintegration time limitReduce cross-link aging effectPharmaceutical non-active ingredientsCapsule deliveryGlycineCross-link
The invention discloses a soft capsule shell composition, a soft capsule, and preparation and an application thereof. The soft capsule shell composition comprises the following components, by mass: (1) 35-45% of gelatin; (2) 10-25% of a plasticizer; (3) 1-5% of glycine as an aldehyde inhibitor; (4) 0.5-3% of fumaric acid as an acidifier; and (5) 35-45% of water. The positive progress effects of the soft capsule shell composition and the soft capsule are that the soft capsule shell composition uses the glycine as the aldehyde inhibitor and the fumaric acid as the acidifier, and so the cross-linking aging effect of the gelatin in the soft capsule prepared by the soft capsule shell composition can be significantly reduced, the disintegration time limit of the soft capsule after long-term storage does not significantly increase, and the medicine dissolution behavior does not significantly change.
Owner:SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
Huoxiang Zhengqi tablet
InactiveCN105079362AExtract completelyHigh extraction rateDigestive systemAntiviralsSide effectCurative effect
The invention relates to a Huoxiang Zhengqi tablet. A preparation method of the medicine disclosed by the invention comprises the following steps: (1) extracting active ingredients of pericarpium arecae, pinellia ternate, radix angelicae and dried orange peel by virtue of a continuous concentration change ethanol extraction method; (2) extracting volatile oil of rhizoma atractylodes and mangnolia officinalis by virtue of a microwave-assisted extraction method; (3) processing poria cocos and mixing a dry extract; and (4) preparing a tablet. By virtue of the preparation method disclosed by the invention, the Huoxiang Zhengqi tablet is rapid to take effect, good in cure effect and low in side effect.
Owner:韩志强
Complete-gastrodia tuber soft capsule and preparation method thereof
ActiveCN101317971AGood stabilityGood water solubilityNervous disorderDigestive systemGastrodiaPlant Tubers
The present invention provides a complete gastrodia tuber soft capsule and a preparation method thereof, which solves the defects of the prior art that the refined gastrodia tuber powder is hardly dissolved in edible oil, easily congregated into particles, delaminated and unevenly dispersed after placement. Calculated by weight portions, the present invention includes the following procedures: taking one portion of gastrodia tuber and grinding the gastrodia tuber into 120 meshes; adding 0.5 to 3 portions of polyglycol400 and propanediol accounting for 8% of the amount of polyglycol400 after sterilization; then evenly mixing, filling and pressing the mixture into soft capsules. Compared with the prior art, the present invention takes polyglycol400 as the diluting agent so that the refined gastrodia tuber powder can be better dispersed. In addition, the present invention has no delamination after placement and excellent stability and can better increase the biological utilization of the soft capsule preparation. The addition of propanediol into the diluting agent can prevent the soft capsule shell from hardening and the disintegration time limit from prolonging in storage. The complete gastrodia tuber soft capsule has obvious curative effect on headache and dizziness, numb limbs and tense tendons, hieronosus and hyperspasmia and other diseases.
Owner:贵州益康制药有限公司
Compound feed for fishing and preparation technology of compound feed
InactiveCN108371264ASmall specific surface areaImprove stabilityFood processingClimate change adaptationEmulsionSodium carboxymethylcellulose
The invention discloses a compound feed for fishing and a preparation technology of the compound feed. The compound feed for fishing comprises a composite compound feed and a layer of slow release membrane sprayed outside the composite compound feed, wherein the thickness of the slow release membrane is 0.3-0.5mm, and emulsion for spraying to form the slow release membrane comprises the followingcomponents by mass of 10.5-11.2% of nanometer calcium carbonate, 8.3-8.6% of lactose, 6.0-6.3% of carboxymethyl cellulose, 6.6-7.0% of polyvinyl alcohol, 5.2-5.5% of polyacrylic acid, 3.2-3.4% of polyacrylamide hydrochloride, 1.3-1.5% of sodium dodecylbenzenesulfonate, 0.3-0.5% of vitamin C, 1.3-1.5% of polyethylene glycol and 10.2-10.5% of ethanol. The emulsion has the advantage of prolonging thetime of disintegrating an effective feed.
Owner:余道逍
Traditional Chinese medicine composition for treating ischemia apoplexy, and capsules and preparation method thereof
ActiveCN104096089AHigh dissolution rateLow costMammal material medical ingredientsCapsule deliveryPANAX NOTOGINSENG ROOTSide effect
The invention relates to a traditional Chinese medicine composition for treating ischemia apoplexy, and capsules and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following constituents: animal horns, gastrodia elata, cornu bubali concentrated powder, Chinese rhubarb, peach seed, panax notoginseng, salviae miltiorrhiza, lumbricus, pangolin, rhizoma chuanxiong, semen raphani and musk. According to the traditional Chinese medicine composition, the effective rate for treating the ischemia apoplexy reaches 92 %, the side-effect is less, and the used raw materials are low in cost; the traditional Chinese medicine composition can be taken and carried more conveniently after being prepared into the capsules; moreover, the therapy effect of the traditional Chinese medicine composition can be developed sufficiently.
Owner:哈尔滨圣泰生物制药有限公司
Pelvic inflammation treating tablet and preparation method thereof
InactiveCN104013684AImprove tablet qualityHigh dissolution ratePill deliveryPharmaceutical non-active ingredientsCarboxymethyl starchClinical efficacy
The invention provides a pelvic inflammation treating tablet and a preparation method thereof, and belongs to the technical field of medicines. The pelvic inflammation treating tablet comprises the following auxiliary materials by weight percent according to the total weight of the tablet: 10-35% of lactose, 1-3% of sodium carboxymethyl starch, 2-5% of microcrystalline cellulose, 0.5-2% of superfine silica powder and 6-15% of medicinal ethanol. Undissolved tablets of traditional Chinese medicine tablets are changed into soluble tablets and instant tablets, so that the problems that all extract tablets of the traditional Chinese medicine are slow to disintegrate and slow to take effect are fundamentally solved, the bioavailability of the traditional Chinese medicine product is improved, and the clinical curative effect of the product is enhanced. The novel medicinal auxiliary materials are refined, and the components are scientific, so that the disintegration time limit of the product is accelerated by 3-4 times on the original basis, the dissolution rate of effective components in the product is increased, and the inherent quality of the traditional Chinese medicine tablet is greatly improved.
Owner:HUNAN PALLADIUM PHARMA
Marbofloxacin flavored tablets and preparation method therefor
PendingCN112089696AImprove palatabilityEasy to administerAntibacterial agentsOrganic active ingredientsFormularyUpper urinary tract infection
The invention provides marbofloxacin flavored tablets and a preparation method therefor. The marbofloxacin flavored tablets comprise the following ingredients in parts by weight: 4-18 parts of marbofloxacin, 50-83.1 parts of filler, 5-30 parts of disintegrant, 0.1-2 parts of lubricant and 0.05-5 parts of flavoring agent. The invention further relates to the preparation method for the marbofloxacinflavored tablets. According to the method provided by the invention, the marbofloxacin is adopted as an effective pharmaceutical ingredient of the oral-administration flavored tablets, and the existing formula is optimized; and thus, the oral-administration flavored tablets prepared by the method can have the following advantages that the palatability is better, the administration is convenient,and the oral-administration flavored tablets can serve as an oral-administration drug for treating deep and shallow skin infection, respiratory tract infection and urinary tract infection of a pet.
Owner:上海信元动物药品有限公司
Guifu Dihuang tablet
InactiveCN105194198AHigh yieldDiversity guaranteedDigestive systemUrinary disorderRadix AconitiChinese cinnamon
The invention relates to a Guifu Dihuang tablet. The preparation method of the Guifu Dihuang tablet comprises the steps that (1) supercritical CO2 extraction of volatile components of cinnamomum cassia and moutan bark is conducted; (2) continuous ethanol concentration change extraction of effective constituents of radix rehmanniae preparata, the fruits of medicinal cornel, Chinese yam and rhizoma alismatis is carried out; (3) aqueous extraction of dregs of a decoction of radix aconiti carmichaeli and the rest of drugs is performed; (4) the tablet is prepared. By the adoption of the preparation method, the Guifu Dihuang tablet which is high in effective constituent content, good in drug effect, high in bioavailability and small in side effect is obtained.
Owner:韩志强
Process for preparing hard hollow capsules from material having thermal gel performance
InactiveCN105832551AEliminates the risk of cross-linking reactionsChange the preparation methodCapsule deliveryCross-linkManufacturing technology
The invention is applicable to the technical field of production of hard hollow capsules, and discloses a process for preparing the hard hollow capsules from a material having a thermal gel performance. The process comprises the following steps: preparing a liquid at normal temperature, heating a mold body, dipping glue and forming, drying and cooling, and de-molding and brushing oil. The process for preparing the hard hollow capsules from the material having the thermal gel performance disclosed by the invention breaks through a conventional hollow capsule production process; on the basis of the principle that gel is generated by thermal gel when encountering water, exiting cold-mold hot-liquid production is replaced by cold-liquid hot-mold production, so that a preparing mode of a preparation liquid is changed, the production process is simplified, energy consumption is reduced, production cost is reduced and a material utilization rate is improved by 30-40%; and the addition of any coagulant aids is avoided, so that a risk that a mutual cross-linking reaction occurs between materials is eliminated and the safety grade of a finished product is improved. The preparation process shortens a drying time, facilitates production and management, improves a production efficiency, effectively controls the stability and the uniformity of the finished product and significantly improves the current situation that the finished product is high in weight difference.
Owner:浙江睿码科技有限公司
Traditional Chinese medicinal composition for treating gout and oral preparation and preparation method thereof
InactiveCN104055876AShort treatment cycleGood treatment effectSkeletal disorderPharmaceutical non-active ingredientsSide effectMedicine
The invention relates to a traditional Chinese medicinal composition for treating gout, a preparation thereof as well as a preparation method thereof. The traditional Chinese medicinal composition is mainly prepared by processing holboellia coriacea, wooly datchmanspipe herb, angelica, ligusticum wallichii, notopterygium root, radix angelicae pubescentis, pawpaw, ash bark, caulis akebiae, sargentgloryvine stem, suberect spatholobus stem, alangium platanifolium, astragalus membranaceus, saussurea involucrate, divaricate saposhnikovia root, radix clematidis and liquorice in parts by weight. Furthermore, the invention discloses a tablet prepared from the traditional Chinese medicinal composition and auxiliary materials. The traditional Chinese medicinal composition and the tablet have good curative effect on gout; effective rate is 100% and side effect is low; moreover, the traditional Chinese medicinal composition is prepared from less medicinal raw materials, thus saving cost.
Owner:万伦
Oral quick-dissolving film preparation and preparation method thereof
InactiveCN102824333BImprove disintegration time limitSolve the shortcomings of taking waterPharmaceutical non-active ingredientsSexual disorderVardenafilTadalafil
The invention discloses an oral quick-dissolving film preparation and a preparation method thereof. The oral quick-dissolving film comprises the following components in percentage by weight: 20 to 40 percent of medicinal active component, 40 to 75 percent of water-soluble film forming material, 10 to 25 percent of plasticizer, 0 to 25 percent of disintegrating agent, and 0.1 to 8 percent of water, wherein the medicinal active component is one of sildenafil, tadalafil, vardenafil or salts thereof. According to the oral quick-dissolving film preparation, the disintegration time limited of the film preparation can be remarkably accelerated, the problem that most oral solid preparations should be taken with water can be solved, medicine taking time cannot be delayed under a condition without water, and the taking compliance of a patient can be improved.
Owner:SUZHOU UNIV
Soft capsule matrix and preparation method thereof
ActiveCN101513531AImprove disintegration time limitOvercoming the problem of unstable natureCapsule deliveryOil/fats/waxes non-active ingredientsMedicineWater soluble
The invention provides a soft capsule matrix and a preparation method thereof. The soft capsule matrix is prepared by seed fat, low melting point accessories and high melting point accessories according to the definite proportion by weight. The soft capsule matrix is simultaneously suitable for water-solubility, oil solubility or insoluble drug requirements, not only increases the applicable scope of soft capsules, but also reduces the mutual influence of contents and rubber sheets to the utmost extent, overcomes the problem of the unstable nature of the traditional soft capsule, accelerates the disintegration time of the soft capsules. The preparation method thereof has simple technique and the selected accessories are universal and easy to be obtained and suitable for commercial process.
Owner:苏州玉森新药开发有限公司
Entecavir oral instant film agent and preparation method thereof
ActiveCN107714676AEasy to carryImprove complianceAntiviralsPharmaceutical non-active ingredientsMedicinePlasticizer
The invention relates to an entecavir oral instant film agent and a preparation method thereof. By referring to the total weight, the entecavir oral instant film agent is prepared from, by mass, 0.05-15% of entecavir, 55-90% of polyving akohol / polyethylene glycol grafted copolymer, 5-15% of glycerin plasticizer, 0.5-15% of sodium alginate disintegrating agent. The invention provides a preparationmethod of the entecavir oral instant film agent, which includes steps of (1), mixing polyving akohol / polyethylene glycol grafted copolymer with water evenly to obtain polymer gel; (2), adding entecavir in the polymer gel; after mixing evenly, adding plasticizer and sodium alginate disintegrating agent, so as to obtain drug-containing solution; (3), degassing the drug-containing solution and thencoating on a substrate; drying at 40-60 DEG C and then cutting, so as to obtain the entecavir oral instant film agent. The entecavir oral instant film agent can significantly accelerate the disintegrating time limit of the film agent and solve the shortcoming that the most oral solid preparation is applied along with water at present; the film agent cannot delay the drug applying time in the absence of water resource and improves the drug compliance of a patient.
Owner:SUZHOU UNIV
Hydrobromic acid vortioxetine oral soluble film agent and preparation method thereof
ActiveCN114681434AEasy to stretchShort disintegration timeOrganic active ingredientsNervous disorderMedicineSoluble Film
The invention relates to the field of pharmaceutical preparations, in particular to a hydrobromic acid vortioxetine oral soluble film agent and a preparation method thereof. The preparation method comprises the following steps: mixing the vortioxetine hydrobromide and auxiliary materials, and sequentially carrying out hot melting, film drawing and cooling to obtain the oral instant film agent. Compared with a solution casting method or other methods, the oral instant film agent prepared by adopting a hot melting method has the advantages that the tensile property of the oral instant film agent is improved, and meanwhile, the disintegration time limit is remarkably shortened. Known by technicians in the field, the improvement of the tensile property can prolong the disintegration time limit, but the invention has the opposite effect that the dissolving property of the mixture disclosed by the invention is possibly changed due to a hot melting method.
Owner:福建瑞泰来医药科技有限公司 +1
A kind of traditional Chinese medicine composition for treating ischemic stroke, capsule and preparation method thereof
ActiveCN104096089BHigh dissolution rateLow costMammal material medical ingredientsCapsule deliveryPANAX NOTOGINSENG ROOTLumbricus
Owner:哈尔滨圣泰生物制药有限公司
A kind of soft capsule composition containing dutasteride and its preparation method
ActiveCN109875973BImprove stabilityNo obvious signs of agingOrganic active ingredientsPharmaceutical non-active ingredientsSoftgelGlycerol
Owner:南京恒生制药有限公司
Melt crystallization preparation technology of DC (direct compression) grade xylitol
ActiveCN101747148BChange crystal formDecreased crystal densityHydroxy compound active ingredientsGranular deliveryEvaporationCompressibility
Owner:FUTASTE PHARM CO LTD
Preparation method of five-flavour musk pills
InactiveCN108478676AExtended drying timeImprove disintegration time limitNervous disorderAntipyreticCooking & bakingMedicine
The invention relates to a preparation method of five-flavour musk pills. The preparation method is characterized by making mixed five-flavour musk pill raw powder into pills with benzoin saturated liquid, evenly wetting the prepared pills with the benzoin saturated liquid, adding the five-flavour musk pill raw powder and rounding the pills, putting the pills into a hot air circulating baking ovento perform primary drying, screening to grade, filling the pills again with the five-flavour musk pill raw powder, putting the pills into the hot air circulating baking oven to perform secondary drying, covering the pills with purified water, and putting into a boiling drying granulator to perform third drying. According to the invention, the pills are prepared by a moulding preparation method instead of a generic preparation method, and are dried by boiling drying after being covered by water instead of hot air circulating drying. The time for preparing the pills and the time for drying areshorten and the production efficiency is improved, and the stability and quality of the products are improved. The produced pills are easy to disintegrate, and the taking of the pills are convenient.The pills are uniform in color, lustre, appearance and shape.
Owner:NINGXIA DUOWEI PHARMA
Preparation method and use of 12-component traditional Chinese medicine
InactiveCN109481607APromote sustainable developmentConducive to the mitigation of sustainable developmentMetabolism disorderCapsule deliveryTraditional medicineSemen
The invention relates to a preparation method and use of a 12-component traditional Chinese medicine. The preparation method can be used for preventing and treating arteriosclerosis and is prepared from the following 12 traditional Chinese medicine raw drugs: angelica, radix curcumae, pubescent holly root, acanthopanax root, rhizoma alismatis, radix bupleuri, herba artemisiae scopariae, rhizoma corydalis, semen cassia, rheum officinale, fructus aurantii and liquorice.
Owner:张秀芳
Soft capsule matrix and preparation method thereof
ActiveCN101513531BImprove disintegration time limitOvercoming the problem of unstable natureCapsule deliveryOil/fats/waxes non-active ingredientsMedicineWater soluble
Owner:苏州玉森新药开发有限公司
Complete-gastrodia tuber soft capsule and preparation method thereof
ActiveCN101317971BGood water solubilityGood dispersionNervous disorderDigestive systemDiseasePEG 400
Owner:贵州益康制药有限公司
Salviae miltiorrhizae oral cavity quick-dissolving film agent and preparation method thereof
InactiveCN106913617AImprove disintegration time limitSolve the shortcomings of taking waterHydroxy compound active ingredientsSheet deliveryActive componentTraditional medicine
The invention belongs to the field of medicinal preparations and particularly relates to a salviae miltiorrhizae oral cavity quick-dissolving film agent and a preparation method thereof. The film agent mainly includes: 1-99% of a traditional Chinese medicine active component, 0.1-50% of a film-forming material, and 0-50% of a pharmaceutical auxiliary material. The film agent has reasonable and creative formula and is safe and effective, overcomes defects in conventional dosage forms, has uniform dosage, good mouth feel and low usage amount, is quick to dissolve and work, is convenient to take and store, and is very suitable for elders, children, mentally retarded people and the like patients with swallowing difficulty.
Owner:安徽安龙基因科技有限公司
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