36results about How to "Improve disintegration time limit" patented technology

The invention discloses an oral quick-dissolving film preparation and a preparation method thereof. The oral quick-dissolving film comprises the following components in percentage by weight: 20 to 40 percent of medicinal active component, 40 to 75 percent of water-soluble film forming material, 10 to 25 percent of plasticizer, 0 to 25 percent of disintegrating agent, and 0.1 to 8 percent of water, wherein the medicinal active component is one of sildenafil, tadalafil, vardenafil or salts thereof. According to the oral quick-dissolving film preparation, the disintegration time limited of the film preparation can be remarkably accelerated, the problem that most oral solid preparations should be taken with water can be solved, medicine taking time cannot be delayed under a condition without water, and the taking compliance of a patient can be improved.

The invention relates to a preparing method of Shiwuwei Longdanhua pills. The method is characterized by comprising the steps of firstly evenly wetting prepared Shiwuwei Longdanhua pill pellets with purified water, adding Shiwuwei Longdanhua pill raw powder and performing round rolling, then putting the Shiwuwei Longdanhua pill pellets into a boiling drying granulator to conduct primary drying, afterwards performing screening, supplementing powder with the Shiwuwei Longdanhua pill raw powder, conduct secondary drying in the boiling drying granulator, finally capping the pellets after secondary drying with the purified water, and only conducting tertiary drying in the boiling drying granulator. According to the preparing method of the Shiwuwei Longdanhua pills, a method of boiling drying is adopted to replace heat-wind circulating drying, accordingly the problems that the pellet drying time is long, the pellets are not easy to disintegrate and the appearance shape is not good are effectively solved, the pellet drying time can be reduced to about 20 h, meanwhile stability of Shiwuwei Longdanhua pill product is effectively improved, and further the product quality is improved; the produced pills are easy to disintegrate and thus convenient to take, the color and luster of the pellets are consistent, and the appearance shape is uniform.

The invention relates to a capsule for treating urinary system diseases and a preparation method thereof. The capsule is a traditional Chinese medicine capsule for treating urinary system infection and inflammations. The preparation method comprises that 30 to 50 parts by mass of Polygonum capitatum D.Don, 20 to 40 parts by mass of all-grass of maidenhair, 10 to 20 parts by mass of amur corktree bark and 4 to 6 parts by mass of auxiliary materials are orderly subjected to extraction, drying, crushing, blending and filling. The capsule for treating urinary system diseases has the effects of clearing away heat and purging pathogenic fire, alleviating water retention and treating stranguria, diminishing inflammation and swelling, and eliminating dampness and inducing diuresis, has good treatment effects on urinary system infection and inflammations caused by stagnation of dampness-heat, is safe and effective, has controllable quality, avoids repeated attack, has no obvious toxic and side effects, does not cause drug resistance, and has a low cost and a high clinical popularization value.

The invention discloses a soft capsule shell composition, a soft capsule, and preparation and an application thereof. The soft capsule shell composition comprises the following components, by mass: (1) 35-45% of gelatin; (2) 10-25% of a plasticizer; (3) 1-5% of glycine as an aldehyde inhibitor; (4) 0.5-3% of fumaric acid as an acidifier; and (5) 35-45% of water. The positive progress effects of the soft capsule shell composition and the soft capsule are that the soft capsule shell composition uses the glycine as the aldehyde inhibitor and the fumaric acid as the acidifier, and so the cross-linking aging effect of the gelatin in the soft capsule prepared by the soft capsule shell composition can be significantly reduced, the disintegration time limit of the soft capsule after long-term storage does not significantly increase, and the medicine dissolution behavior does not significantly change.

The present invention provides a complete gastrodia tuber soft capsule and a preparation method thereof, which solves the defects of the prior art that the refined gastrodia tuber powder is hardly dissolved in edible oil, easily congregated into particles, delaminated and unevenly dispersed after placement. Calculated by weight portions, the present invention includes the following procedures: taking one portion of gastrodia tuber and grinding the gastrodia tuber into 120 meshes; adding 0.5 to 3 portions of polyglycol400 and propanediol accounting for 8% of the amount of polyglycol400 after sterilization; then evenly mixing, filling and pressing the mixture into soft capsules. Compared with the prior art, the present invention takes polyglycol400 as the diluting agent so that the refined gastrodia tuber powder can be better dispersed. In addition, the present invention has no delamination after placement and excellent stability and can better increase the biological utilization of the soft capsule preparation. The addition of propanediol into the diluting agent can prevent the soft capsule shell from hardening and the disintegration time limit from prolonging in storage. The complete gastrodia tuber soft capsule has obvious curative effect on headache and dizziness, numb limbs and tense tendons, hieronosus and hyperspasmia and other diseases.

The invention discloses a compound feed for fishing and a preparation technology of the compound feed. The compound feed for fishing comprises a composite compound feed and a layer of slow release membrane sprayed outside the composite compound feed, wherein the thickness of the slow release membrane is 0.3-0.5mm, and emulsion for spraying to form the slow release membrane comprises the followingcomponents by mass of 10.5-11.2% of nanometer calcium carbonate, 8.3-8.6% of lactose, 6.0-6.3% of carboxymethyl cellulose, 6.6-7.0% of polyvinyl alcohol, 5.2-5.5% of polyacrylic acid, 3.2-3.4% of polyacrylamide hydrochloride, 1.3-1.5% of sodium dodecylbenzenesulfonate, 0.3-0.5% of vitamin C, 1.3-1.5% of polyethylene glycol and 10.2-10.5% of ethanol. The emulsion has the advantage of prolonging thetime of disintegrating an effective feed.

The invention provides a pelvic inflammation treating tablet and a preparation method thereof, and belongs to the technical field of medicines. The pelvic inflammation treating tablet comprises the following auxiliary materials by weight percent according to the total weight of the tablet: 10-35% of lactose, 1-3% of sodium carboxymethyl starch, 2-5% of microcrystalline cellulose, 0.5-2% of superfine silica powder and 6-15% of medicinal ethanol. Undissolved tablets of traditional Chinese medicine tablets are changed into soluble tablets and instant tablets, so that the problems that all extract tablets of the traditional Chinese medicine are slow to disintegrate and slow to take effect are fundamentally solved, the bioavailability of the traditional Chinese medicine product is improved, and the clinical curative effect of the product is enhanced. The novel medicinal auxiliary materials are refined, and the components are scientific, so that the disintegration time limit of the product is accelerated by 3-4 times on the original basis, the dissolution rate of effective components in the product is increased, and the inherent quality of the traditional Chinese medicine tablet is greatly improved.

The invention is applicable to the technical field of production of hard hollow capsules, and discloses a process for preparing the hard hollow capsules from a material having a thermal gel performance. The process comprises the following steps: preparing a liquid at normal temperature, heating a mold body, dipping glue and forming, drying and cooling, and de-molding and brushing oil. The process for preparing the hard hollow capsules from the material having the thermal gel performance disclosed by the invention breaks through a conventional hollow capsule production process; on the basis of the principle that gel is generated by thermal gel when encountering water, exiting cold-mold hot-liquid production is replaced by cold-liquid hot-mold production, so that a preparing mode of a preparation liquid is changed, the production process is simplified, energy consumption is reduced, production cost is reduced and a material utilization rate is improved by 30-40%; and the addition of any coagulant aids is avoided, so that a risk that a mutual cross-linking reaction occurs between materials is eliminated and the safety grade of a finished product is improved. The preparation process shortens a drying time, facilitates production and management, improves a production efficiency, effectively controls the stability and the uniformity of the finished product and significantly improves the current situation that the finished product is high in weight difference.

The invention relates to a traditional Chinese medicinal composition for treating gout, a preparation thereof as well as a preparation method thereof. The traditional Chinese medicinal composition is mainly prepared by processing holboellia coriacea, wooly datchmanspipe herb, angelica, ligusticum wallichii, notopterygium root, radix angelicae pubescentis, pawpaw, ash bark, caulis akebiae, sargentgloryvine stem, suberect spatholobus stem, alangium platanifolium, astragalus membranaceus, saussurea involucrate, divaricate saposhnikovia root, radix clematidis and liquorice in parts by weight. Furthermore, the invention discloses a tablet prepared from the traditional Chinese medicinal composition and auxiliary materials. The traditional Chinese medicinal composition and the tablet have good curative effect on gout; effective rate is 100% and side effect is low; moreover, the traditional Chinese medicinal composition is prepared from less medicinal raw materials, thus saving cost.

The invention relates to a preparation method of five-flavour musk pills. The preparation method is characterized by making mixed five-flavour musk pill raw powder into pills with benzoin saturated liquid, evenly wetting the prepared pills with the benzoin saturated liquid, adding the five-flavour musk pill raw powder and rounding the pills, putting the pills into a hot air circulating baking ovento perform primary drying, screening to grade, filling the pills again with the five-flavour musk pill raw powder, putting the pills into the hot air circulating baking oven to perform secondary drying, covering the pills with purified water, and putting into a boiling drying granulator to perform third drying. According to the invention, the pills are prepared by a moulding preparation method instead of a generic preparation method, and are dried by boiling drying after being covered by water instead of hot air circulating drying. The time for preparing the pills and the time for drying areshorten and the production efficiency is improved, and the stability and quality of the products are improved. The produced pills are easy to disintegrate, and the taking of the pills are convenient.The pills are uniform in color, lustre, appearance and shape.

The invention relates to a preparation method and use of a 12-component traditional Chinese medicine. The preparation method can be used for preventing and treating arteriosclerosis and is prepared from the following 12 traditional Chinese medicine raw drugs: angelica, radix curcumae, pubescent holly root, acanthopanax root, rhizoma alismatis, radix bupleuri, herba artemisiae scopariae, rhizoma corydalis, semen cassia, rheum officinale, fructus aurantii and liquorice.