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Salviae miltiorrhizae oral cavity quick-dissolving film agent and preparation method thereof

An oral instant film preparation, Salvia miltiorrhiza technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., can solve the problems of poor stability, slow release speed, difficulty in swallowing, etc. The effect of improving medication compliance and accelerating disintegration time

Inactive Publication Date: 2017-07-04
安徽安龙基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such pharmaceutical preparations have disadvantages such as slow release rate, poor stability, and difficulty in swallowing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 salvia miltiorrhiza oral cavity instant film

[0022] 1) Weigh 20 g of Salvia miltiorrhiza and add 90% ethanol to reflux, recover ethanol after filtration, concentrate the filtrate to a thick ointment, add water to decoct the dregs, combine the filtered liquid with the above thick ointment, concentrate under reduced pressure, and set aside;

[0023] 2) Weigh 60 ml of 3% hydroxymethylcellulose aqueous solution, 0.3 g of mint essence, 5 g of 15% glycerin solution, 0.5 g of xylitol, 3 g of β-cyclodextrin, and 2 g of microcrystalline cellulose, and heat After melting, add the above-mentioned thick paste, and stir evenly to obtain a gel;

[0024] 3) Degassing, apply the above gel evenly on the flat plate, blow air, heat and dry, the heating temperature is 65 ℃. Cut to obtain a 0.2 um thick oral instant film of traditional Chinese medicine.

[0025] The film is light yellow-green in color, has good flexibility, almost no peculiar smell, disso...

Embodiment 2

[0026] Example 2 Preparation of compound salvia miltiorrhiza oral instant film

[0027] 1) Weigh 45 g of Salvia miltiorrhiza and 14.1 g of Panax notoginseng, grind them into powder, add water to decoct, filter, concentrate the filtrate, add ethanol and let it stand for 20 minutes, take the supernatant, recover ethanol, concentrate into a thick paste, and set aside;

[0028] 2) Weigh 0.8 g borneol and grind finely. Separately weigh 60 ml of 3% hydroxymethylcellulose aqueous solution, 0.3 g of mint essence, 5 g of 15% glycerin solution, 0.5 g of xylitol, 3 g of β-cyclodextrin, and 2.5 g of microcrystalline cellulose, and heat to make Melt, add the above-mentioned thick cream together with borneol fine powder, stir evenly to get a gel;

[0029] 3) Degassing, spread the above-mentioned gel evenly on the flat plate, blow air, heat and dry, and the heating temperature is 65 ℃. Cut to obtain a 0.2 um thick oral instant film of traditional Chinese medicine.

[0030] The film is yel...

Embodiment 3

[0031] Example 3 Preparation of Coronary Salvia Miltiorrhiza Oral Instant Film

[0032] 1) Weigh 100 g of Salvia miltiorrhiza, grind it into powder, add 90% ethanol to reflux, collect the reflux liquid, recover the ethanol and concentrate; add water to decoct the salvia miltiorrhiza root for 2 times, filter and concentrate the filtrate, combine with the first filtrate and concentrate into a thick paste;

[0033] 2) Weigh 100 g of notoginseng and grind it into fine powder, add it to the thick paste prepared in 1), then add 0.88 g of balsamic oil, and stir evenly;

[0034] 3) Weigh 50 g of the mixture in 2) and dissolve it in 50 ml of 75% ethanol, and sonicate until dissolved.

[0035] 4) Weigh 60 ml of 3% hydroxymethylcellulose aqueous solution, 0.3 g of mint essence, 5 g of 15% glycerin solution, 0.5 g of xylitol, 3 g of β-cyclodextrin, and 2.5 g of microcrystalline cellulose, and heat After melting, add it to the solution obtained in 3), and stir evenly to obtain a gel;

...

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Abstract

The invention belongs to the field of medicinal preparations and particularly relates to a salviae miltiorrhizae oral cavity quick-dissolving film agent and a preparation method thereof. The film agent mainly includes: 1-99% of a traditional Chinese medicine active component, 0.1-50% of a film-forming material, and 0-50% of a pharmaceutical auxiliary material. The film agent has reasonable and creative formula and is safe and effective, overcomes defects in conventional dosage forms, has uniform dosage, good mouth feel and low usage amount, is quick to dissolve and work, is convenient to take and store, and is very suitable for elders, children, mentally retarded people and the like patients with swallowing difficulty.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a salvia-like oral instant film and a preparation method thereof, in particular to an oral instant film for treating diseases such as cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular disease mortality ranks first in the composition of disease deaths in my country. The "China Cardiovascular Disease Report 2015" shows that although the age-standardized mortality rate of cardiovascular disease in my country has declined, the total number of cardiovascular disease deaths is still rising rapidly due to factors such as population aging. The prevalence of hypertension, dyslipidemia, diabetes and obesity in the population continues to increase, and the task of curbing the growth of cardiovascular diseases is still very arduous. In 2014, 2 out of 5 deaths were due to cardiovascular disease. Therefore, the effective prevention and treatment of cardi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/70A61P9/00A61P9/10A61K31/045
Inventor 韦玉军李航李静苏军吴远航
Owner 安徽安龙基因科技有限公司
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