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Soft capsule matrix and preparation method thereof

A soft capsule and matrix technology, which is applied in the direction of capsule delivery, oil/fat/wax non-active ingredients, etc., can solve the problems of changing the physical properties of the contents, affecting the stability of the contents, and unstable properties of traditional Chinese medicine soft capsules. The method is simple in process and has the effect of accelerating the disintegration time limit

Active Publication Date: 2013-06-19
苏州玉森新药开发有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional soft capsules use oily bases, which are generally used for oily and low melting point drugs, such as evening primrose oil soft capsules, oyster essential oil soft capsules, etc. In recent years, domestic research on Chinese medicine soft capsules has developed rapidly, and the contents have transitioned to suspensions, semi- Solid, which greatly increases the scope of use of soft capsules, but the problem of unstable properties of traditional Chinese medicine soft capsules is ubiquitous and unresolved. The main reason is that the contents react with the rubber. The ingredients are reduced, or the physical properties of the contents are changed; on the other hand, the disintegration time of the soft capsule is delayed, resulting in unqualified product quality

Method used

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  • Soft capsule matrix and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] formula:

[0019] Ingredients Weight Ratio

[0020] 100 parts cocoa butter

[0021] 1 part beeswax

[0022] Preparation Process:

[0023] Weigh the materials according to the formula, mix and heat, wait for melting, stir evenly, keep warm at 40°C for later use, or store after cooling. When in use, heat to melt, stir evenly, and keep warm at 40°C for use.

Embodiment 2

[0025] Ingredients Weight Ratio

[0026] 70 parts cocoa butter

[0027] 40 parts soybean oil

[0028] 5 parts beeswax

[0029] The preparation process is the same as in Example 1.

Embodiment 3

[0031] Ingredients Weight Ratio

[0032] 70 parts cocoa butter

[0033] 70 parts soybean oil

[0034] 10 parts beeswax

[0035] The preparation process is the same as in Example 1.

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Abstract

The invention provides a soft capsule matrix and a preparation method thereof. The soft capsule matrix is prepared by seed fat, low melting point accessories and high melting point accessories according to the definite proportion by weight. The soft capsule matrix is simultaneously suitable for water-solubility, oil solubility or insoluble drug requirements, not only increases the applicable scope of soft capsules, but also reduces the mutual influence of contents and rubber sheets to the utmost extent, overcomes the problem of the unstable nature of the traditional soft capsule, accelerates the disintegration time of the soft capsules. The preparation method thereof has simple technique and the selected accessories are universal and easy to be obtained and suitable for commercial process.

Description

technical field [0001] The invention belongs to the fields of health food and pharmaceutical preparations, and in particular relates to a soft capsule composition and a preparation method thereof. Background technique [0002] Soft capsule refers to a solid preparation made by injecting the contents quantitatively and encapsulating them in an elastic soft film. The contents are composed of drugs and matrix, which can be liquid, semi-solid or solid. Soft capsules have strong plasticity, beautiful appearance, and are easy to be accepted by patients. At present, the application of soft capsules in traditional Chinese medicine is still a relatively new technology. It is suitable for drugs with high oil content, difficult to dissolve in water, difficult to absorb, unstable to light, humidity and heat, easy to oxidize, and have bad smell, which can ensure the quality of the product , improve bioavailability. [0003] Traditional soft capsules use oily bases, which are generally ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/44A61K9/48
Inventor 韩庆惠张丽芝玄振玉陈叶明王小虎邹珊珊华琰
Owner 苏州玉森新药开发有限公司
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