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Povidone iodine effervescent tablets with anti-microbial, skin-care and anti-inflammation functions and production process of povidone iodine effervescent tablets

A technology of povidone iodine and anti-inflammatory effect, which is applied in the field of preparation of disinfectant and medical disinfectant to achieve the effect of simplifying the administration steps, simple equipment and alleviating pain

Inactive Publication Date: 2016-06-08
SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the shortcoming of above-mentioned prior art, provide a kind of povidone-iodine that can realize and overcome the shortcoming that current effervescent tablet production technology is generally relatively complicated, simple production technology concurrently has antibacterial, skin care and anti-inflammation effect Effervescent tablet and its production process

Method used

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  • Povidone iodine effervescent tablets with anti-microbial, skin-care and anti-inflammation functions and production process of povidone iodine effervescent tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A povidone-iodine effervescent tablet with antibacterial, skin care and anti-inflammatory effects, consisting of the following components in mass percent:

[0029] Povidone-iodine: 10%; Tartaric acid: 36%; Sodium bicarbonate: 35%; Cross-linked polyvinylpyrrolidone: 5%; Menthol: 0.1%; Camphor powder: 1%; Allantoin: 2%; Pine: 0.1%; Zinc oxide: 0.01%; Microcrystalline cellulose: 0.01%; Dextrin: 0.1%; Polyethylene oxide: 0.5%; Magnesium lauryl sulfate: 5%; The balance is filled with sodium chloride .

[0030] Wherein the composite polymer synergist is composed of: menthol: 10%; camphor powder: 1%; allantoin: 12.5%; vitamin E: 5%; hydrocortisone: 1%, and the balance is polyvinylpyrrolidone (The molecular weight is about 40000).

[0031] Carry out tabletting according to the above-mentioned formula according to the following process steps, must pay attention to control the humidity of production site below 30%. After testing, the irritation index is very light, and the dis...

Embodiment 2

[0033] A povidone-iodine effervescent tablet with antibacterial, skin care and anti-inflammatory effects, consisting of the following components in mass percent:

[0034] Povidone-iodine: 11%; Tartaric acid: 37.8%; Sodium bicarbonate: 31%; Cross-linked polyvinylpyrrolidone: 4%;

[0035] Menthol: 0.28%; Camphor Powder: 0.82%; Allantoin: 1.8%; Hydrocortisone: 0.28%; Zinc Oxide: 0.025%; Microcrystalline Cellulose: 0.13%; Dextrin: 0.33%; Polyepoxy Ethane: 1.4%; magnesium lauryl sulfate: 3.78%; the balance is filled with sodium chloride.

[0036] Wherein the composite polymer synergist is composed of: menthol: 7.5%; camphor powder: 10%; allantoin: 10%; vitamin E: 3%; hydrocortisone: 3%, and the balance is polyvinylpyrrolidone (The molecular weight is about 40000).

[0037] Carry out tabletting according to the above-mentioned formula according to the following process steps, must pay attention to control the humidity of production site below 30%. After testing, the irritation in...

Embodiment 3

[0039] A povidone-iodine effervescent tablet with antibacterial, skin care and anti-inflammatory effects, consisting of the following components in mass percent:

[0040]Povidone iodine: 12%; tartaric acid: 39.6%; sodium bicarbonate: 27%; cross-linked polyvinylpyrrolidone: 3%; menthol: 0.46%; camphor powder: 0.64%; allantoin: 1.6%; Pine: 0.46%; Zinc oxide: 0.05%; Microcrystalline cellulose: 0.25%; Dextrin: 0.55%; Polyethylene oxide: 2.3%; Magnesium lauryl sulfate: 2.55%; The balance is filled with sodium chloride .

[0041] Wherein the composite polymer synergist is composed of: menthol: 5%; camphor powder: 7.5%; allantoin: 20%; vitamin E: 1%; hydrocortisone: 5%, and the balance is polyvinylpyrrolidone (The molecular weight is about 40000).

[0042] Carry out tabletting according to the above-mentioned formula according to the following process steps, must pay attention to control the humidity of production site below 30%. After testing, the irritation index is very light, ...

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Abstract

The invention relates to povidone iodine effervescent tablets with anti-microbial, skin-care and anti-inflammation functions and a production process of the povidone iodine effervescent tablets. The effervescent tablets comprise 10%-15% of povidone iodine, 51%-80% of an effervescent disintegrating agent, 1%-5.5% of a tablet disintegrating agent, 1.3%-5% of a compound polymer synergist, 0.01%-0.1% of zinc oxide, 0.05%-0.5% of dextrin, 0.5%-5% of polyethylene oxide, 0.1%-5% of a lubricant and the balance of filler. According to the effervescent tablets, a medicine integrating anti-microbial, anti-inflammation and skin-care functions and having complete functions is developed by carefully studying the function mechanism of medicines after multiple experiments, the anti-inflammation function is realized in the disinfection process, and the medicine administration step is simplified in the medical process. Besides, pain of a patient in the medicine use process is relieved, and detection shows that the irritation of the effervescent tablets in the formula is extremely small and is much lower than that of like products. The preparation process is simple and convenient to operate, the equipment is simple, and the product is convenient to use, transport and carry and suitable for industrial large-scale popularization and use.

Description

technical field [0001] The invention relates to the field of preparation of disinfectants, in particular to the field of preparation of medical disinfectants, in particular to a povidone-iodine effervescent tablet with antibacterial, skin care and anti-inflammatory effects and a production process thereof. Background technique [0002] Povidone-iodine is a complex compound of polyvinylpyrrolidone (generally PVP-K30) and iodine. It is a non-ionic iodophor with iodine as the main bactericidal component. It is currently the most widely used and safest antibacterial disinfectant. It is included in the world's major pharmacopoeias such as Chinese Pharmacopoeia, American Pharmacopoeia, European Pharmacopoeia, British Pharmacopoeia, and Japanese Pharmacopoeia. Povidone-iodine has been made into various dosage forms for sterilization and disinfection of skin and mucous membranes of the human body as well as aquatic animal husbandry and other fields, and the curative effect is obviou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/79A61P31/02A61P17/00
CPCA61K9/0007A61K9/2059A61K31/79
Inventor 王宇熊俊超陈占蒋华攀
Owner SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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