Povidone iodine effervescent tablet with sterilization and disinfection effects, and preparation method thereof

A technology of povidone iodine and disinfection, which is applied in the field of disinfection preparations, can solve the problems of not having anti-inflammatory, skin care and analgesic effects, and achieve the effects of long disintegration time limit and complex production process

Inactive Publication Date: 2017-04-19
郑州普罗动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are many brands of povidone-iodine effervescent tablets sold in the market, but they all just make full use of the excellent slow-release bactericidal effect of povidone-iodine, and do not have anti-inflammatory, skin-care and pain-relieving effects.

Method used

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  • Povidone iodine effervescent tablet with sterilization and disinfection effects, and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] The present embodiment provides a povidone-iodine effervescent tablet with sterilization and disinfection, which is prepared from the following raw materials in parts by weight: 10 parts of povidone-iodine, 4 parts of fumaric acid, and 4 parts of sodium bicarbonate , 10 parts of mannitol, 5 parts of povidone K30, 67 parts of microcrystalline cellulose.

[0031] The present invention also provides the preparation method of the above-mentioned povidone-iodine effervescent tablet with sterilization and disinfection, comprising the following steps:

[0032] (1) Get 20 parts of microcrystalline cellulose and add sodium bicarbonate to granulate, and dry the granules after passing through a 50-mesh sieve;

[0033] (2) Take 20 parts of microcrystalline cellulose and add fumaric acid to granulate, and dry the granules after passing through a 50-mesh sieve;

[0034] (3) Merge the granules obtained in step (1) and step (2), then add povidone iodine, mannitol, povidone K30 and the...

Embodiment 2

[0036] This embodiment provides a povidone-iodine effervescent tablet with sterilization and disinfection effects, which is prepared from the following raw materials in parts by weight: 5 parts of povidone-iodine, 6 parts of fumaric acid, and 2 parts of sodium bicarbonate , 15 parts of mannitol, 3 parts of povidone K30, 70 parts of microcrystalline cellulose.

[0037] The present invention also provides the preparation method of the above-mentioned povidone-iodine effervescent tablet with sterilization and disinfection, comprising the following steps:

[0038] (1) Get 20 parts of microcrystalline cellulose and add sodium bicarbonate to granulate, and dry the granules after passing through a 50-mesh sieve;

[0039] (2) Take 20 parts of microcrystalline cellulose and add fumaric acid to granulate, and dry the granules after passing through a 50-mesh sieve;

[0040] (3) Merge the granules obtained in step (1) and step (2), then add povidone iodine, mannitol, povidone K30 and the...

Embodiment 3

[0042] This embodiment provides a povidone-iodine effervescent tablet with sterilization and disinfection effects, which is prepared from the following raw materials in parts by weight: 15 parts of povidone-iodine, 2 parts of fumaric acid, and 6 parts of sodium bicarbonate , 5 parts of mannitol, 8 parts of povidone K30, 60 parts of microcrystalline cellulose.

[0043] The present invention also provides the preparation method of the above-mentioned povidone-iodine effervescent tablet with sterilization and disinfection, comprising the following steps:

[0044] (1) Get 20 parts of microcrystalline cellulose and add sodium bicarbonate to granulate, and dry the granules after passing through a 50-mesh sieve;

[0045] (2) Take 20 parts of microcrystalline cellulose and add fumaric acid to granulate, and dry the granules after passing through a 50-mesh sieve;

[0046] (3) Merge the granules obtained in step (1) and step (2), then add povidone iodine, mannitol, povidone K30 and the...

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Abstract

The invention discloses a povidone iodine effervescent tablet with sterilization and disinfection effects, and a preparation method thereof, and belongs to the technical field of disinfection preparations. The povidone iodine effervescent tablet is prepared from, by weight, 5-15 parts of povidone iodine , 2-6 parts of fumaric acid, 2-6 parts of sodium bicarbonate, 5-15 parts of mannitol, 3-8 parts of povidone K30 and 60-70 parts of microcrystalline cellulose. The invention also discloses the preparation method of the povidone iodine effervescent tablet. The povidone iodine effervescent tablet can be used for sterilizing water and disinfecting environment, devices and water used for animal body skins. The povidone iodine effervescent tablet is a disinfection antiseptic, and has a killing effect on multiple bacteria, spores, viruses and fungi. The action mechanism of the povidone iodine effervescent tablet is that the povidone iodine effervescent table depolymerizes and releases contained iodine for acting a bactericidal effect after the povidone iodine effervescent tablet is in contact with wounds or infected parts. The povidone iodine effervescent tablet has small irritation to tissues, is suitable for treating skin and mucous membrane infection, is a high-efficiency and low-toxicity sterilization medicine, and has a good killing effect on bacteria, viruses and fungi.

Description

technical field [0001] The invention relates to the technical field of disinfection preparations, in particular to a povidone-iodine effervescent tablet with sterilization and disinfection functions. Background technique [0002] Povidone-iodine is a prodrug preparation, an amorphous compound formed by combining polyvinylpyrrolidone and iodine, containing 9% to 12% of available iodine, and is a new type of water-soluble iodine for external use. Compared with tincture of iodine (iodine solution), it has the characteristics of stable properties, good water solubility, non-irritating and volatile, mild and long-lasting effect, safe use, easy elution of chromatography, etc. It is an efficient, broad-spectrum, low-toxic disinfection fungicide. Its antibacterial mechanism is due to the surface activity and emulsification of PVP-I. On the one hand, the penetration of PVP-I is enhanced; inside, and the leakage of cell contents leads to the death of microorganisms. The results of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/12A01N37/06A01N25/34A61K31/79A01P1/00A01P3/00A61K9/46A61K47/12A61K47/02A61K47/10A61K47/38A61K47/32A61P31/02A61P31/04A61P31/10A61P31/12
CPCA01N59/12A01N25/34A01N37/06A61K9/0007A61K9/2009A61K9/2013A61K9/2054A61K31/194A61K31/79A61K2300/00A01N2300/00
Inventor 冉毅
Owner 郑州普罗动物药业有限公司
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