Rapidly disintegrable Zhenju antihypertensive tablets and preparation method thereof

Abstract

The invention discloses rapidly disintegrable Zhenju antihypertensive tablets and a preparation method thereof, which are used for solving the problems that the conventional Zhenju antihypertensive tablets are unstable in uniformity and slow in disintegration and absorption, and the like. The rapidly disintegrable Zhenju antihypertensive tablets are characterized by comprising 70 to 90 percent of principal drug, 5 to 15 percent of disintegrating agent, 10 to 20 percent of thinning agent, 1 to 3 percent of lubricating agent, 3 to 8 percent of coating agent, and the balance of wetting agent, wherein the disintegrating agent comprises carboxymethyl starch sodium, cross-linked polyvinylpyrrolidone and lauryl sodium sulfate which are used together, and the weight ratio of the three is (8 to 15):(8 to 15):(1 to 3), wherein the lauryl sodium sulfate is used as an external disintegrating agent; the carboxymethyl starch sodium is used as an internal and external disintegrating agent, and the weight ratio of the internal addition to the external addition is 2:1; and the cross-linked polyvinylpyrrolidone is used as an internal and external disintegrating agent, and the weight ratio of the internal addition to the external addition is 4:1. The exploration on the selection, using method and dosage of auxiliary materials is carried out, the uniformity and controllability of product quality are ensured, and the rapidly disintegrable Zhenju antihypertensive tablets have the advantages of uniform dispersion and rapid disintegration.

Description

technical field [0001] The invention relates to a Chinese-Western compound preparation, in particular to a Zhenju antihypertensive tablet with many main ingredients and small specifications and a preparation method thereof. Background technique [0002] Zhenju Jiangya Tablets is made of 1000 tablets of wild chrysanthemum cream powder, 100g of nacre powder, 30mg of clonidine hydrochloride, 5g of hydrochlorothiazide, 20g of rutin and medicinal excipients. Fire, clearing the head, calming the liver and lowering blood pressure; pearl layer powder has the effects of calming the liver and suppressing yang, calming the nerves, calming convulsions, clearing heat and improving eyesight; rutin can reduce the permeability of capillaries, increase the tension of capillaries, and can Lowers the level of triglycerides in human serum; clonidine hydrochloride is a central alpha 2 Adrenergic receptor agonists can lower blood pressure and heart rate by reducing the activity of human sensory ...

AI Technical Summary

Problems solved by technology

Yet Zhenju Jiangya Tablet also has certain deficiencies, clonidine hydrochloride, hydrochlorothiazide specifications (i.e. dosage) are very small, difficult to mix, content uniformity is not good; Disintegration time is significantly prolonged, reducing its bioavailability

Due to the poor content uniformity, moisture absorption and agglomeration, the peak-valley effect of blood drug concentration will be large, and the fluctuation degree of blood pressure is large, which is not conducive to stable blood pressure reduction. Therefore, a western medicine with good content uniformity and rapid disintegration of Chinese medicine ingredients has been developed. Zhenju antihypertensive tablet and its preparation method are very necessary

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