Complete-gastrodia tuber soft capsule and preparation method thereof
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A technology of soft capsules and Gastrodia elata, which is applied in the field of Gastrodia elata preparations and its preparation. It can solve the problems of Gastrodia elata fine powder being difficult to dissolve and disperse, unable to be made into soft capsules, and uneven dispersion, so as to improve bioavailability and prevent disintegration time limit Prolonged, pronounced therapeutic effect
Active Publication Date: 2008-12-10
贵州益康制药有限公司
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Problems solved by technology
The applicant found in practice that Gastrodia elata fine powder is not easy to dissolve and disperse in edible oil, and will ag
Method used
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[0038] Take the gastrodia elata and dry it and pulverize it into a fine powder of 120 mesh, then perform low-temperature intermittent sterilization at 75-80°C for 3 times, 12 hours each time, then add polyethylene glycol and propylene glycol, grind in a colloid mill for 10 minutes and mix well, spray The body temperature is set to 44°C, and 4000 soft capsules are sprayed and filled.
[0039] Usage and dosage: Orally, 4-12 capsules each time, 3 times a day.
[0041] Take the gastrodia elata and dry it and crush it into a fine powder of 120 mesh, and then perform low-temperature intermittent sterilization at 75-80°C for 3 times, 12 hours each time, then add polyethylene glycol and propylene glycol, mix well, fill, and press to make a soft capsule 4000 grain.
[0042] Usage and dosage: Orally, 4-12 capsules each time, 3 times a day.
[0044] Take the gastrodia elata and dry it and crush it into a fine powder of 120 mesh, and then perform low-temperature intermittent sterilization at 75-80°C for 3 times, 12 hours each time, then add polyethylene glycol and propylene glycol, mix well, fill, and press to make a soft capsule 4000 grain.
[0045] Usage and dosage: Orally, 4-12 capsules each time, 3 times a day.
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Abstract
The present invention provides a complete gastrodia tuber soft capsule and a preparation method thereof, which solves the defects of the prior art that the refined gastrodia tuber powder is hardly dissolved in edible oil, easily congregated into particles, delaminated and unevenly dispersed after placement. Calculated by weight portions, the present invention includes the following procedures: taking one portion of gastrodia tuber and grinding the gastrodia tuber into 120 meshes; adding 0.5 to 3 portions of polyglycol400 and propanediol accounting for 8% of the amount of polyglycol400 after sterilization; then evenly mixing, filling and pressing the mixture into soft capsules. Compared with the prior art, the present invention takes polyglycol400 as the diluting agent so that the refined gastrodia tuber powder can be better dispersed. In addition, the present invention has no delamination after placement and excellent stability and can better increase the biological utilization of the soft capsule preparation. The addition of propanediol into the diluting agent can prevent the soft capsule shell from hardening and the disintegration time limit from prolonging in storage. The complete gastrodia tuber soft capsule has obvious curative effect on headache and dizziness, numb limbs and tense tendons, hieronosus and hyperspasmia and other diseases.
Description
technical field [0001] The invention relates to a whole gastrodia elata preparation and a preparation method thereof, in particular to a whole gastrodia elata soft capsule preparation and a preparation method thereof. Background technique [0002] Gastrodia elata has relatively good curative effect on diseases such as headache, dizziness, limb numbness, but the effect of direct use is not ideal. In the prior art, Gastrodia elata is made into whole Gastrodia elata capsules or Gastrodia elata tablets, but they are only crushed into Gastrodia elata in the production process. The fine powder (fineness is 80-100 meshes), sterilized and filled into capsules or added with appropriate excipients and compressed into tablets. These drugs have relatively poor stability, are easy to absorb moisture, and have low bioavailability and poor effect. [0003] The original dosage form of Gastrodia elata is capsule, because capsule has above-mentioned problem, so the marketability of commodity...
Claims
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Application Information
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