158 results about "Urinary tract infection (UTI)" patented technology

The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).

The present invention relates to the field of bacteriology. In particular, the invention relates to compositions of probiotic microbes and methods for making and using such compositions, e.g. in the treatment and prevention of catheter associated urinary tract infections.

Disclosed is a system that prevents the development of infection and biofilm establishment in medical devices in general, and in particular Urinary Tract Infections (UTI), including Catheter-Associated Urinary Tract Infections (CAUTI). The system comprises of a medical device (such as a catheter) and an antimicrobial composition containing an antimicrobial compound. A medical device delivers the composition both to the inside and / or outside portions of the device, as well as to the inside of the bladder itself and to the urethra. Reduction or elimination of the infection may be accomplished by irrigating the medical device, bathing the bladder, or irrigating the bladder with the composition.

The invention relates to the field of biological medicine, in particular to an application of Rakicidins compounds in resistance to clinical pathogenic anaerobic bacteria. Pharmacodynamic experiments indicate that the Rakicidins compounds have good resistant effect on the clinical pathogenic anaerobic bacteria and have the resistant effect on vancomycin enterococcus infection diseases. The Rakicidins compounds can be used for treating diarrhea, enteritis, alimentary infection, oral infection or skin acne caused by clostridium difficile as well as diseases such as urinary tract infection, or skin soft-tissue infection and the like.

A cavity (3) such as the urethra of a patient is lined by providing a lining device that comprises an eversible chamber (12) and a liner (16) connected thereto. Fluid pressure is applied to the chamber (12) to cause the chamber (12) to evert and advance into the cavity (3) such that the chamber (12) carries the liner (16) into the cavity. A vacuum is then applied to the chamber (12) to cause it to deflate. A part, such as a catheter or cable, can then be inserted into the cavity through the liner (16). If the cavity is the urethra of a patient, the liner shields the catheter from the distal part (1) of the urethra which is colonised with bacteria, and therefore reduces the risk of a urinary tract infection.

The present invention provides one kind of Chinese medicine preparation for treating urinary system calculus and urinary tract infection and its preparation process. The Chinese medicine preparation has functions of clearing away heat, promoting diuresis, treating stranguria, diminishing inflammation, relieving pain and removing urinary calculus. It is used in treating urinary calculus, renal colic, urinary tract infection and other urinary tract diseases.

The invention provides a group of novel medicinal compositions for treating infectious diseases of the urogenital system such as urinary tract infection and prostatitis, wherein the composition comprises the pharmaceutical effective combinations of the following materials: I) anti-infectious medicaments and second compounds of the precursors and pharmaceutically acceptable salts of the anti-infectious medicaments; II) medicaments for treating urethra stimulative symptoms, such as muscarinic receptor antagonist, alpha-adrenergic receptor antagonist and 5-alpha-reductase inhibitor or phosphodiesterase (PDE) antagonist and second compounds of the precursors and pharmaceutically acceptable salts of the medicaments; and III) analgesic medicaments or dopes and second compounds of the precursorsand pharmaceutically acceptable salts of the analgesic medicaments or dopes. The three classes of medicaments can be combined two by two (such as I+II, II+III or I+III) or combined together (such as I+II+III). The invention also provides group of novel methods for treating infectious diseases of the urogenital system such as urinary tract infection and prostatitis, which comprises a step of usinga therapeutically effective dose of the compositions of the invention.

A sample analyzer comprising: a light source for emitting light to particles contained in a measurement sample which is prepared from a reagent and a urine sample collected from a subject; a detector for detecting scattered light and fluorescence which are generated from the particles in the measurement sample; a display; and a controller, wherein the controller executes operations comprising: obtaining particle data based on the scattered light and the fluorescence which are detected from the particles by the detector; and controlling, when the particle data satisfies a predetermined condition, the display to display information indicating a possibility that the subject is infected with an uncomplicated urinary tract infection is disclosed.

The invention provides a Chinese medicine preparation capable of diminishing inflammation, relieving pains, resisting bacteria, expelling stone and benefiting gallbladder, a preparation method thereof and applications of the Chinese medicine preparation in preparing medicines for treating urinary system calculi, urinary tract infection, cholecystitis, gall-stone and prostatitis. According to the theory of Chinese medicines, through the experiment and screening for many years, the invention reselects raw drugs in the prescription, optimizes the preparation technology, greatly enhances the medicinal functions of promoting diuresis for stranguria and removing heat for detumescence, has unexpected obvious curative effect on treating urinary system diseases, and especially produces unexpected effects of resisting bacteria, resisting prostatitis, relieving pains and benefiting gallbladder which are not provided in the prior art. The Chinese medicine preparation of the invention exerts the traditional advantages of Chinese medicines, takes effect quickly, obviously improves the subjective symptom and the physical sign, and does not have obvious side effect.

An operation process of catheter placement will seriously stimulate a urethra and a bladder clinically, physiological and pathological stenosis and curve of the urethra of a human body will make it harder to place the catheter and will aggravate damage to a lower urinary tract in a placement process, and damage to the lower urinary tract will induce or aggravate lower urinary tract infection, which will further affect functions of the lower urinary tract or organs of the whole body. Methods for treating urethrostenosis currently include: 1, a high strength head or metallic probe bar or guide wire is used to enhance an external force to push the catheter, which will cause damage to an inner membrane of the urinary tract and even infection; 2, an outer surface of the urinary tract is paintedwith a lubricating oil or a lubricating coating, but the this method is not useful in urethrostenosis while being used independently. The invention provides a stenosis dilated catheter; and when thestenosis dilated catheter is placed, an expandable portion of a fin section of the head is filled, the urinary tract is painted with a lubricating agent, the placement successful rate is improved, andthe damage and infection risk is minimized.

The invention provides a cefuroxime sodium compound and a new preparation method thereof. The method comprises the following steps: performing acid-base reaction, absorbing with activated carbon, and separating and purifying with a chromatographic column. By adopting the method, the purity and content of cefuroxime sodium can be greatly increased, the product quality of the preparation can be increased, the toxic or side effects can be reduced and the safety of the preparations of the medicines for curing respiratory tract infection and urinary tract infection can be ensured; and compared with the prior art, the method has the advantages of simple and practical technology, mild reaction conditions, low cost, high yield and high product purity and is suitable for industrial production.

The invention discloses a novel medicinal use of the active parts of abelmoschus manihot general flavones, in particular use of the active parts of abelmoschus manihot general flavones in the preparation of medicaments for treating urinary tract infection including cystitis and urethritis. Abelmoschus manihot has the effects of disinhibiting water, dissipating stasis, dispersing swelling, detoxification and relieving common symptoms of urinary tract infection, such as frequent micturition, urgent urination, odynuria and unwell micturition. The active parts of abelmoschus manihot general flavones have excellent inhibiting effects on staphylococcus aureus, staphylococcus epidermidis and other gram-positive bacteria and negative bacteria, and have anti-inflammatory and pain-relieving effects and an obvious diuretic effect. Therefore, the active parts of abelmoschus manihot general flavones have excellent effects on the treatment of urinary tract infection, particularly chronic recurrent urinary tract infection.

The present invention provides novel compounds of Formula (I′) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and / or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and / or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and / or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).

The present invention provides one kind of acute urinary tract infection treating medicine and its preparation process. The medicine is developed based on the pathogenesis of stranguria to dredge Liver Meridian Qi stagnation and clear lower-Jiao wetness and heat. The medicine is prepared with bupleurum root, skullcap root, pinkweed and other medicine materials. Experiment shows that the medicine has the following functions: resisting Gram-negative bacterium causing urinary tract infection, reducing the inflammation reaction of kidney in urinary tract infection mouse mold, inhibiting colibacillus to adhere to bladder epidermis of mouse, inhibiting common inflammation obviously, relieving chemically caused pain of mouse abdominal cavity, increasing the post-water load urea amount of rat, etc.

The invention discloses a Chinese medicinal external composition for curing gynecological diseases and a preparation method thereof. The composition is prepared from amur corktree bark, hairyvein agrimonia herb and bud, common cnidium fruit, climbing groundsel herb, dried alum and borneol in a certain ratio. The composition is prepared into clinically acceptable external formulations such as suppository, external capsules, gel, ointments, vaginal tablets, vaginal effervescent tablets, vaginal films, lotion, aerosol, foaming agent and the like by a pharmaceutical conventional method. The composition has good curative effects on cervical erosion, gynecological inflammation, and urinary tract infection of women. The composition is prepared into an external preparation and is not orally administrated so as to avoid first-pass effect on liver and physiological screening effects of gastrointestinal tracts and reduce untoward effect. The external preparation can directly act on afflicted parts, and has the advantages of strong pertinence, general actions through skin and mucosa, quick medicinal absorption, less interference to internal environment of body, non-traumatic treatment mode, simple operation, good safety of clinical use, high cure rate, base strengthening of Chinese medicaments, and less side effect. The composition can effectively eliminate cause of diseases, can safely and effectively cure diseases under guidance of doctors and is easy to popularize.

The present invention discloses one kind of Chinese medicine soft capsule for treating urinary system diseases and its preparation process. The preparation process includes dissolving suspending agent in dispersant, adding Chinese medicine extractum powder and mixing homogeneous to obtain capsule liquid; dissolving gelatin in water, adding glycerin, polyol, iron oxide sodium metabisulfite and ethyl hydroxyl benzoate, mixing homogeneously decompression to debubble to obtain capsule shell; and pressing or dropping to prepare the soft capsule. The Chinese medicine extractum powder is prepared with Cherokee rose root, scabrousstem greenbrier rhizome, Yangkaikou, Jinshateng and centella, and through decoction, filtering, concentrating, drying and crushing. The Chinese medicine soft capsule is used in treating acute and chronic pyelonephritis, acute cystitis, urinary tract infection and other diseases, and has the advantages of high bioavailability, fast absorption, etc.

The invention relates to cefathiamidine monocrystal, a preparation method, use and a composition thereof. The cefathiamidine monocrystal disclosed by the invention is prepared by comprising the following steps of: adding three solvents, namely ethanol, water and acetone, into a clean conical flask in any sequence according to any proportion, wherein the volume ratio of ethanol, water to acetone is (4-10):1:(0.05-3.67), during, before or after adding various solvents, adding cefathiamidine, dissolving at room temperature, and preparing cefathiamidine solution with the concentration of 0.05-0.5 g / ml; sealing by using a plastic film, and pricking a plurality of small holes on the plastic film; storing at 0-15 DEG C; and beginning to generate tiny crystals after about 48 h, and then obtaining cefathiamidine monocrystal after above 96 h. The preparation method disclosed by the invention is simple and convenient for operation and simple in equipment; the prepared monocrystal is good in stability; the cefathiamidine monocrystal composition disclosed by the invention is a composition composed of monocrystal and pharmaceutically acceptable carriers, preferably injection; the cefathiamidine monocrystal disclosed by the invention can be used for preparing medicines for treating respiratory tract infection, biliary tract infection, urinary tract infection, wound and surgical infection, skin and soft tissue infection, gynaecological infection, ear-nose-throat infection, endocarditis, blood poisoning, pneumonia and meningitis.

The invention discloses a quality inspection method for a capsule for treating lower urinary tract infection. The method comprises steps of: a chromatographic condition and system applicability test; preparation of a reference solution; preparation of a sample solution by taking about 2g of a product, adding 25ml of methanol precisely, heating for reflux for 30 min, cooling, weighing, supplementing lost weight with methanol, shaking evenly, filtering, precisely weighing 2ml of a subsequent filtrate, placing the subsequent filtrate in a 50ml round-bottom flask, volatilizing methanol, adding 10ml of 2.5mol / L sulfuric acid solution, conducting an ultrasonic treatment for 5 min, then adding 10ml of trichloromethane, heating to reflux for 1 h, separating out a trichloromethane solution, extracting an acid solution with trichloromethane by shaking for 2 times, emerging the trichloromethane solution, dehydrating, volatilizing trichloromethane, precisely adding 10ml of methanol into the residue, heating gently to dissolve the residue, cooling, supplementing lost weight with methanol, shaking evenly, filtering, and taking a subsequent filtrate to obtain the sample solution; and precisely drawing 20 muL of the reference solution and the sample solution respectively; and injecting the solution into a liquid chromatograph for determination. The method provided by the invention can not only ensure the efficacy of the product but also stabilize product quality.

The invention belongs to the technical field of medicaments, and in particular relates to a medicine for treating urinary tract infection. The main active component of the medicine disclosed by the invention is polysaccharide extracted from caryophyllaceae vaccaria segetalis (Neck.) Garcke. The polysaccharide in the invention is from vaccaria segetalis (Neck.) Garcke seeds. A method for preparingthe vaccaria segetalis (Neck.) Garcke polysaccharide and vaccaria segetalis (Neck.) Garcke polysaccharide medicine composition provided by the invention is simple and effective, and capable of being prepared into a variety of common oral forms, such as solid, liquid and the like. The medicine disclosed by the invention is mainly used for treating the urinary tract infection as well as frequent micturition, urgent urination and odynuria caused by diabetes. Compared with the traditional medicines, the medicine disclosed by the invention has an obvious curative effect, low recurrence rate and notoxic and side effects, and the product quality is stable and controllable.

Methods for identifying and providing therapeutic solutions for treating polymicrobial infections, such as but not limited to urinary tract infections. The methods herein feature detection and identification of organisms of the polymicrobial infection, phenotypic pooled sensitivity tests for determining the susceptibility or resistance of the polymicrobial infection in the sample to an antibiotic or other therapeutic agent, and identification of resistance genes, e.g., genetic markers that may indicate resistance to a particular treatment. Together, the data can be applied against databases of antibiotic / therapeutic susceptibility or resistance for particular known polymicrobial infections in order to provide one or more therapeutic solutions for the polymicrobial infection.

The invention provides a medicament for treating chronic annexitis, pelvic inflammatory disease, vaginitis and urinary tract infection, and the process for its preparation. The medicament is prepared from Chinese medicinal herbs including Sichuan chinaberry, corydalis tuber, Chinese angelica root, root of red rooted saliva, nutgrass flatsedge rhizome, radix paeoniae rubrathe, burred tuber, zedoary, Poria cocos, gorgon euryale seed, corktree bark, flavescent sophora root and Chinese yam. The medicament can be prepared into the forms of pills, capsule, granule and soft capsule.

The invention discloses a medicine composition which is mainly prepared from desmodium styracifolium, asiatic centella, oldenlandia diffusa, milk veteh, pyrrosia lingua, lygodium japonicum and giant knotweed. The medicine composition has the efficacy of clearing away heat and toxic materials as well as removing dampness and treating stranguria, and is used for stranguria, difficulty and pain in micturition and urinary tract infection which are caused by damp heat accumulation; and the adaptation diseases include frequent urination, urgent urination, dysuria, dark yellow urine and urinary tract infection. The medicine composition can be prepared into various oral liquid.

The invention relates to the technical field of surgery, and discloses a surgical urine suction device capable of generating negative pressure and adjusting strength based on intermittent movement, the surgical urine suction device comprises a shell, the interior of the shell is fixedly connected with a negative pressure bottle, urine in the body is discharged by using negative pressure, and through cooperative use of a piston, a push rod, a support rod and a special-shaped disc, the device can be driven to intermittently generate negative-pressure environments, accordingly, genitals of patients can be prevented from being injured by the aid of the negative-pressure urine suction device under negative-pressure conditions for a long time, and pain in urination procedures can be increased; through cooperative use of a first trapezoidal shaft, a transverse rod, a vertical rod and a second trapezoidal shaft, the negative pressure strength of the urine suction device can be adjusted according to the conditions of different patients, the practicability of the whole device is improved, through cooperative use of a negative pressure bottle and a collecting bottle, sucked urine can be transferred into the collecting bottle in a unified mode. Urine is prevented from flowing back along the negative pressure tube, urinary tract infection is reduced, and safety in use is improved.

The invention discloses novel applications of forsythin, forsythin derivative, and a composition of forsythin and forsythiaside in preparing medicines for alleviating or / and treating urinary tract infection. The experiment proves that when used for treating urinary tract infection, forsythin, the forsythin derivative, and the composition of forsythin and forsythiaside have obvious curative effects, are rapid in taking effect, and are small in toxic and side effects, the prepared medicine is safe, efficient and stable, a preparation technology is simple and is suitable for industrial production, and the popularization is easy. A novel medicine resource is provided for preventing and treating urinary tract infection and complications of urinary tract infection.

The invention belongs to the field of traditional Chinese pharmacology, and specifically relates to traditional Chinese medicine sugar-free granules for treating upper respiratory tract infection, tonsillitis, urinary tract infection, acute bacillary dysentery and enteritis and a preparation method thereof. The Yanning sugar-free granules are prepared from the following raw material medicines and accessories in parts by weight: 500 parts of savatier monochasma herb, 250 parts of oldenlandia diffusa, 250 parts of herba commelinae, 10-30 parts of diluent and 2-6 parts of flavoring agent, and preferentially from 500 parts of savatier monochasma herb, 250 parts of oldenlandia diffusa, 250 parts of herba commelinae, 10 parts of dextrin and 4 parts of steviosin. In the invention, a large amount of sucrose in the traditional Yanning granules is replaced by the diluent and the flavoring agent, thus the appropriate population is expanded, the best diluent dextrin and flavoring agent steviosin are determined, and the best forming technology is determined; and the Yanning granules have the advantages of brown appearance, appropriate hardness, low hygroscopicity and the like, and are easy to prepare.

Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and / or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and / or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and / or hydrolysable tannins, wherein said tannins are bound to an anti-cancer agent and / or liposomes containing an anti-cancer agent, together with compositions related thereto.

The present invention provides novel compounds of Formula (I′) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and / or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and / or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and / or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).

The invention relates to a medicament for treating urinary infection and lithiasis, which is prepared from the following medicinal materials in parts by weight: 1-5 parts of aspidopterys glabriuscula, 1-3 parts of wild reed cereal roots, 1-3 parts of conical celastrus orbiculatus, 1-3 parts of folium orthosiphoni and 1-2 parts of liquorice. The medicament is used for treating acute and chronic nephritis, pyelitis, urinary tract infection, renal calculi, ureter calculi, bladder calculi and the like; the medicament prepared into different preparations by applying the modern technique is applied in clinics to obtain an obvious therapeutic effect, and the research on the main pharmacodynamics proves that the medicament has no toxic or side reaction, safe and has reliable and obvious therapeutic effect, good development and application prospect and market competitiveness through clinical therapeutic effect observation and urgent toxin test.