147 results about "Urinary tract infection (UTI)" patented technology

The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).

The invention relates to the field of biological medicine, in particular to an application of Rakicidins compounds in resistance to clinical pathogenic anaerobic bacteria. Pharmacodynamic experiments indicate that the Rakicidins compounds have good resistant effect on the clinical pathogenic anaerobic bacteria and have the resistant effect on vancomycin enterococcus infection diseases. The Rakicidins compounds can be used for treating diarrhea, enteritis, alimentary infection, oral infection or skin acne caused by clostridium difficile as well as diseases such as urinary tract infection, or skin soft-tissue infection and the like.

The invention provides a Chinese medicine preparation capable of diminishing inflammation, relieving pains, resisting bacteria, expelling stone and benefiting gallbladder, a preparation method thereof and applications of the Chinese medicine preparation in preparing medicines for treating urinary system calculi, urinary tract infection, cholecystitis, gall-stone and prostatitis. According to the theory of Chinese medicines, through the experiment and screening for many years, the invention reselects raw drugs in the prescription, optimizes the preparation technology, greatly enhances the medicinal functions of promoting diuresis for stranguria and removing heat for detumescence, has unexpected obvious curative effect on treating urinary system diseases, and especially produces unexpected effects of resisting bacteria, resisting prostatitis, relieving pains and benefiting gallbladder which are not provided in the prior art. The Chinese medicine preparation of the invention exerts the traditional advantages of Chinese medicines, takes effect quickly, obviously improves the subjective symptom and the physical sign, and does not have obvious side effect.

The present invention provides one kind of acute urinary tract infection treating medicine and its preparation process. The medicine is developed based on the pathogenesis of stranguria to dredge Liver Meridian Qi stagnation and clear lower-Jiao wetness and heat. The medicine is prepared with bupleurum root, skullcap root, pinkweed and other medicine materials. Experiment shows that the medicine has the following functions: resisting Gram-negative bacterium causing urinary tract infection, reducing the inflammation reaction of kidney in urinary tract infection mouse mold, inhibiting colibacillus to adhere to bladder epidermis of mouse, inhibiting common inflammation obviously, relieving chemically caused pain of mouse abdominal cavity, increasing the post-water load urea amount of rat, etc.

The present invention discloses one kind of Chinese medicine soft capsule for treating urinary system diseases and its preparation process. The preparation process includes dissolving suspending agent in dispersant, adding Chinese medicine extractum powder and mixing homogeneous to obtain capsule liquid; dissolving gelatin in water, adding glycerin, polyol, iron oxide sodium metabisulfite and ethyl hydroxyl benzoate, mixing homogeneously decompression to debubble to obtain capsule shell; and pressing or dropping to prepare the soft capsule. The Chinese medicine extractum powder is prepared with Cherokee rose root, scabrousstem greenbrier rhizome, Yangkaikou, Jinshateng and centella, and through decoction, filtering, concentrating, drying and crushing. The Chinese medicine soft capsule is used in treating acute and chronic pyelonephritis, acute cystitis, urinary tract infection and other diseases, and has the advantages of high bioavailability, fast absorption, etc.

The invention discloses a quality inspection method for a capsule for treating lower urinary tract infection. The method comprises steps of: a chromatographic condition and system applicability test; preparation of a reference solution; preparation of a sample solution by taking about 2g of a product, adding 25ml of methanol precisely, heating for reflux for 30 min, cooling, weighing, supplementing lost weight with methanol, shaking evenly, filtering, precisely weighing 2ml of a subsequent filtrate, placing the subsequent filtrate in a 50ml round-bottom flask, volatilizing methanol, adding 10ml of 2.5mol / L sulfuric acid solution, conducting an ultrasonic treatment for 5 min, then adding 10ml of trichloromethane, heating to reflux for 1 h, separating out a trichloromethane solution, extracting an acid solution with trichloromethane by shaking for 2 times, emerging the trichloromethane solution, dehydrating, volatilizing trichloromethane, precisely adding 10ml of methanol into the residue, heating gently to dissolve the residue, cooling, supplementing lost weight with methanol, shaking evenly, filtering, and taking a subsequent filtrate to obtain the sample solution; and precisely drawing 20 muL of the reference solution and the sample solution respectively; and injecting the solution into a liquid chromatograph for determination. The method provided by the invention can not only ensure the efficacy of the product but also stabilize product quality.

Methods for identifying and providing therapeutic solutions for treating polymicrobial infections, such as but not limited to urinary tract infections. The methods herein feature detection and identification of organisms of the polymicrobial infection, phenotypic pooled sensitivity tests for determining the susceptibility or resistance of the polymicrobial infection in the sample to an antibiotic or other therapeutic agent, and identification of resistance genes, e.g., genetic markers that may indicate resistance to a particular treatment. Together, the data can be applied against databases of antibiotic/therapeutic susceptibility or resistance for particular known polymicrobial infections in order to provide one or more therapeutic solutions for the polymicrobial infection.

The invention discloses a medicine composition which is mainly prepared from desmodium styracifolium, asiatic centella, oldenlandia diffusa, milk veteh, pyrrosia lingua, lygodium japonicum and giant knotweed. The medicine composition has the efficacy of clearing away heat and toxic materials as well as removing dampness and treating stranguria, and is used for stranguria, difficulty and pain in micturition and urinary tract infection which are caused by damp heat accumulation; and the adaptation diseases include frequent urination, urgent urination, dysuria, dark yellow urine and urinary tract infection. The medicine composition can be prepared into various oral liquid.

The invention discloses novel applications of forsythin, forsythin derivative, and a composition of forsythin and forsythiaside in preparing medicines for alleviating or/and treating urinary tract infection. The experiment proves that when used for treating urinary tract infection, forsythin, the forsythin derivative, and the composition of forsythin and forsythiaside have obvious curative effects, are rapid in taking effect, and are small in toxic and side effects, the prepared medicine is safe, efficient and stable, a preparation technology is simple and is suitable for industrial production, and the popularization is easy. A novel medicine resource is provided for preventing and treating urinary tract infection and complications of urinary tract infection.

The invention relates to antibacterial nursing gel containing a fullerene C60 component and a preparation method thereof. The fullerene C60, the sodium hyaluronate, the carbomer, the aloe extract, theglycogen and the silk peptide protein in the raw materials containing the fullerene C60 component can improve skin nutrition metabolism, so that the skin is tender and smooth, wrinkles are removed, the elasticity is increased, water is supplemented, moisture is preserved, and aging is prevented; the horopito extract, the helichrysum bracteatum extract, the centellae herba extract and the Chineseswitchhazel extract in the raw materials can maintain the cleanness and sanitation of the whole private part for long time, inhibit the growth of harmful microorganisms and prevent vagina and urinarytract infection; the kacip fatimah, the white jasmine, the carob and the evening primrose in the raw materials can effectively care female uterus health. The antibacterial nursing gel containing the fullerene C60 component has the antibacterial rate of over 90% on staphylococcus aureus, escherichia coli and candida albicans and has a very good protection effect on vulvitis, vaginitis, cervicitis and cervical erosion to relieve dryness of private parts of women and realize a lubricating effect.

The invention discloses a private protection probiotic composition, and belongs to the field of all related food industries of probiotics. The composition comprises lactobacillus rhamnosus, lactobacillus paracasei and cranberry powder. The private protection probiotic composition can be taken for a long time, effectively reduces the pH value in the vagina, increases the lactobacillus content in the vagina, can achieve safe and lasting colonization in the vagina, can inhibit the activity of various pathogenic bacteria, and can be used as a food supplement or medicine for improving various urogenital system diseases including bacterial vaginitis (BV), yeast vaginitis (YV) and urinary tract infection (UTI) and reducing infection and recurrence risks.

The invention discloses a novel E3 ubiquitin ligase TcpC and an application thereof. According to the invention, the TcpC has a ubiquitination function, and not only can cause ubiquitination in vitro,but also can cause ubiquitination in vivo. A research of the invention shows that the TIR containing protein encoded by E.coliprotein (TcpC) which contains a Toll/interleukin 1 receptor structural domain and is secreted by a uropathogenic E. coli CFT073 strain can enhance ubiquitination degradation of myeloid differentiation factor 88 (MyD88) in a toll-like receptor (TLR) signal pathway, block the TLR signal pathway, inhibit macrophage-mediated inherent immune function, and is closely related to occurrence of urinary tract infection such as pyelonephritis and the like caused by the uropathogenic E. coli (UPEC). The invention finds that a prokaryotic expression recombinant protein rTcpC can cause reduction of the MyD88 protein of macrophages in a dose-dependent manner, but does not influence transcription of myd88 mRNA, and the rTcpC can obviously enhance the ubiquitination level of the MyD88 in cells and in vitro. According to the invention, the TcpC can be used as a target point forpreparing medicaments for treating urinary tract infection, and is also a molecular marker for clinical laboratory examination of patients with urinary tract infection.

The invention belongs to the field of urine collectors, and particularly relates to an external-hanging type automatic storage ultraviolet sterilization urine collector combination box. The external-hanging type automatic storage ultraviolet sterilization urine collector combination box comprises a combination box body, wherein a cover plate is installed at the top of the combination box body; a collecting pot is placed in the combination box body; a liquid inlet is formed in the top of the collecting pot; a hose is placed in the liquid inlet; an anti-backflow pipe is fixedly installed at one end of the hose; a urine receiving hopper is installed at one end of the anti-backflow pipe; an L-shaped fixing plate is fixedly installed on one side of the combination box body; a first hole is formed in the inner wall of one side of the combination box body; a box door is hinged into the first hole; a U-shaped frame is fixedly installed on the inner wall of one side of the combination box body; and the same rotating shaft is rotationally installed on the inner walls of the two sides of the U-shaped frame. The external-hanging type automatic storage ultraviolet sterilization urine collector combination box is reasonable in design, can be externally hung at different positions of a sickbed, and is convenient to adjust, the cover plate is convenient to open, the urine receiving hopper is convenient to move out, a patient can conveniently use the urine collector combination box, the urine receiving hopper is convenient to store and disinfect, and the possibility of urinary tract infection can be reduced.