The invention belongs to the field of
animal model construction, and discloses a method for constructing a chronic obstructive
pulmonary disease rabbit model. Comprising the following steps: under the condition that the ethics of experimental animals are met, anesthetizing a rabbit, exposing an
airway by using an animal laryngoscope, immediately using a
brush with a proper size to enter the
airway, and repeating controllable physical scraping injury to complete injury; after the rabbits are awakened, the rabbits continue to be raised, and
protease atomization treatment is conducted on the rabbits in the raising process. According to the methods of some examples, complex
gene manipulation or expensive long-term
smoke exposure equipment is not needed, operation is easy, tracheal puncture,
intubation and
tracheotomy are not needed, damage to rabbits is small, the modeling period is short, repetition is easy, the success rate is high, the experiment cost is low, and model rabbits have the advantages of being consistent in damage degree and stable in
pathological change. According to the methods of some examples, the physical damage degree and the
protease dosage are controllable, so that the consistency and the stability of the model are remarkably improved, the
repeatability is good, and the success rate is high.