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Medicine for treating urinary tract infection

A technology for urinary tract infection and seeds is applied in the field of medicine to achieve the effects of low recurrence rate, stable and controllable quality, and convenient administration.

Active Publication Date: 2011-11-16
淮安首考科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese medicine name of barley seed is Wangbuliuxing, also known as Jingonghua, Jianjinhua, Jinscissors, Calendula Yintai, Mailanzi, etc. It is traditionally used in women for dysmenorrhea and amenorrhea; milk retention; Breast carbuncle; Diuretic and stranguria-relieving embolisms There are still many deficiencies in the current research and development of barley cabbage: 1. Although it is recorded in the classics of traditional Chinese medicine that barley cabbage has the effect of diuresis and treating stranguria, its medicinal activity and its medicinal ingredients are both There is no relevant literature report; 2. The research on barley cabbage mainly focuses on small molecular substances, so far there is no research report on the structure and activity of barley cabbage macromolecules, including polysaccharides; 3. Traditionally, barley cabbage is only It is used in traditional Chinese medicine compound prescriptions, but there is no report of single medication

Method used

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  • Medicine for treating urinary tract infection
  • Medicine for treating urinary tract infection
  • Medicine for treating urinary tract infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take an appropriate amount of barley seeds, heat and reflux with 5 times the amount of distilled water, extract three times, each extraction time is 1.5 hours, combine the three extracts, filter with a 150-mesh double-layer filter cloth, heat and concentrate the filtrate to 1 / 3 of the original volume; 4 times of ethanol was added to the concentrated extract under stirring, and after standing still for 12 hours, the precipitate was collected to obtain the crude polysaccharide of barley cabbage. Add distilled water to the crude polysaccharide precipitate to dissolve it, make it fully redissolved, add trichloroacetic acid to a concentration of 1-10%, let it stand for 3 hours after stirring, heat and concentrate the solution to 1 / 3 of the original volume, and concentrate the extract under stirring 4 times of ethanol was added to it, and after standing for 12 hours, the precipitate was collected. The precipitate was washed 3 times with an appropriate amount of absolute ethan...

Embodiment 2

[0025] Take an appropriate amount of barley seeds, heat and reflux with 5 times the amount of distilled water, extract three times, each extraction time is 1.5 hours, combine the three extracts, filter with a 150-mesh double-layer filter cloth, heat and concentrate the filtrate to 1 / 3 of the original volume; 4 times of ethanol was added to the concentrated extract under stirring, and after standing still for 12 hours, the precipitate was collected to obtain the crude polysaccharide of barley cabbage. Add distilled water to the crude polysaccharide precipitate to dissolve it, make it fully redissolved, adjust the pH to 7, add 3% trypsin, soak at 65°C for 1.5h, then add 2.5% papain, soak at 55°C for 1.5h. Ultrafiltration with a membrane filter with a molecular weight cut-off of 10,000. Collect the retentate, add 500mL of 75% ethanol, let it stand for 12h, and collect the precipitate. The precipitate was washed 3 times with an appropriate amount of absolute ethanol, and dried to...

Embodiment 3

[0028] Take an appropriate amount of barley seeds, add 5 times the amount of distilled water, and carry out microwave extraction. The microwave power is 600w, and the extraction time is 10 minutes. to 1 / 3 of the original volume; add 4 times of ethanol to the concentrated extract under stirring, and after standing for 12 hours, collect the precipitate to obtain the crude polysaccharide of barley cabbage. Add distilled water to the crude polysaccharide precipitate to dissolve, heat to 70°C to fully redissolve, heat and concentrate the solution to 1 / 3 of the original volume, add 4 times of ethanol to the concentrated extract under stirring, let it stand for 12 hours, and collect precipitation. The precipitate was washed 3 times with an appropriate amount of absolute ethanol, and dried to obtain the refined polysaccharide of barley cabbage. The refined polysaccharide of barley lettuce can be further prepared into various pharmaceutically acceptable compositions and various dosage...

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Abstract

The invention belongs to the technical field of medicaments, and in particular relates to a medicine for treating urinary tract infection. The main active component of the medicine disclosed by the invention is polysaccharide extracted from caryophyllaceae vaccaria segetalis (Neck.) Garcke. The polysaccharide in the invention is from vaccaria segetalis (Neck.) Garcke seeds. A method for preparingthe vaccaria segetalis (Neck.) Garcke polysaccharide and vaccaria segetalis (Neck.) Garcke polysaccharide medicine composition provided by the invention is simple and effective, and capable of being prepared into a variety of common oral forms, such as solid, liquid and the like. The medicine disclosed by the invention is mainly used for treating the urinary tract infection as well as frequent micturition, urgent urination and odynuria caused by diabetes. Compared with the traditional medicines, the medicine disclosed by the invention has an obvious curative effect, low recurrence rate and notoxic and side effects, and the product quality is stable and controllable.

Description

1. Technical field [0001] The invention relates to a medicine for treating urinary tract infection and a preparation method thereof, belonging to the technical field of medicine. [0002] 2. Background technology [0003] Urinary tract infection refers to urinary tract inflammation caused by a large number of microorganisms in the urinary tract, which is more common in female patients. Urinary tract infection is one of the more common clinical bacterial infectious diseases, second only to respiratory tract infection in infectious diseases. The most common pathogenic bacteria are G-bacteria, accounting for 80-90%, among which Escherichia coli is the most common, followed by Proteus, Klebsiella, Pseudomonas aeruginosa, etc.; G+ cocci infection accounts for 5-10% of urinary infections, Mainly Streptococcus faecalis and Staphylococcus aureus. There are also special infections such as Mycobacterium tuberculosis infection. The clinical features of urinary tract infection are ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/36A61P13/02A61P31/04A61K131/00
Inventor 张海江
Owner 淮安首考科技有限公司
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