Marbofloxacin beef flavored tablets and preparation method thereof

Abstract

The invention discloses marbofloxacin beef flavored tablets and a preparation method thereof; each 1000 slices of the flavored tablets are prepared from 20 g of marbofloxacin, 425-465 g of D-(+)-lactose monohydrate, 75 g of cross-linked povidone, 5 g of povidone K-30, 45-85 g of a beef extract, 4.8 g of silica, 6 g of magnesium stearate and 100 g of purified water as raw materials. The preparation method comprises the following steps: 1) preparing a mixed solution containing povidone K-30 and the beef extract; 2) preparing a soft material; 3) preparing wet particles; 4) drying; 5) screening and stabilizing the size; 6) adding silica and magnesium stearate into the size-stabilized particles in the step 5), and mixing evenly; and 7) pressing the particles mixed in the step 6) into drug tablets by using a tabletting machine. The flavored tablets are good in palatability and convenient to administrate, has quality meeting requirements of the Pharmacopoeia, and has treatment effects and side effects the same as those of other marbofloxacin tablets without addition of flavoring agents in markets. The preparation method is simple, the operation is convenient, and the preparation cost is low.

Description

technical field [0001] The invention relates to the technical field of antibiotics for dogs, in particular to a marbofloxacin beef-flavored tablet and a preparation method thereof. Background technique [0002] Marbofloxacin is a new type of fluoroquinolone antibacterial drug for animals. The antibacterial mechanism is mainly to inhibit bacterial DNA topoisomerase, thereby hindering the synthesis of bacterial DNA. Marbofloxacin has a broad antibacterial spectrum, has strong antibacterial activity against Gram-positive bacteria (especially Staphylococcus and Streptococcus), and has strong antibacterial activity against Gram-negative bacteria (Escherichia coli, Salmonella, Pasteurella, Klebsiella Bacteria, Proteus, Pseudomonas aeruginosa, Bordetella, Shigella, Haemophilus, Pseudomonas, Brucella) sensitive, also effective for mycoplasma, chlamydia, widely used in dogs against infection, currently No drug-resistant strains have been found. [0003] Marbofloxacin is administer...

AI Technical Summary

Problems solved by technology

[0005] At present, Marbofloxacin tablets do not contain flavoring agents. Because Marbofloxacin has a bitter taste, dogs often show resistance during the feeding process, which is very inconvenient to use, and there is even a risk of being bitten by dogs.

Beef extract has a strong beef flavor, which can well cover the bitter taste of marbofloxacin, and the beef flavor is the taste that dogs like. Adding marbofloxacin tablets will significantly improve the palatability and taste of marbofloxacin tablets. It is easy to use, so the successful development of Marbofloxacin Beef Flavor Tablets is of great significance, but there is no relevant research report so far

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