Marbofloxacin beef flavored tablets and preparation method thereof

A beef-flavored and marbofloxacin technology is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients. It can solve problems such as bite wounds and inconvenient use, and achieve easy operation, Convenience in feeding and the effect of improving palatability

Active Publication Date: 2016-10-12
湖北回盛生物科技有限公司
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Marbofloxacin tablets do not contain flavoring agents. Because Marbofloxacin has a bitter taste, dogs often show resistance during the feeding process, which is very inconvenient to use, and there is even a risk of being bitten by dogs.
Beef extract has a strong beef flavor, which can well cover the bitter taste o

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Marbofloxacin beef flavored tablets and preparation method thereof
  • Marbofloxacin beef flavored tablets and preparation method thereof
  • Marbofloxacin beef flavored tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A kind of marbofloxacin beef flavor sheet, every 1000 this flavor sheet is prepared from the raw material of following quality:

[0041]

[0042]

[0043] The preparation method of above-mentioned marbofloxacin beef flavor slices, its steps are:

[0044] 1) Weigh or measure marbofloxacin, D-(+)-lactose monohydrate, crospovidone, povidone, beef extract, silicon dioxide, magnesium stearate and purified water;

[0045] 2) Add povidone K-30 into purified water, heat to 90°C, add beef extract, and stir until povidone K-30 and beef extract are completely dissolved to obtain a mixed solution;

[0046] 3) After mixing marbofloxacin, D-(+)-lactose monohydrate and crospovidone evenly, while stirring, add the mixed solution obtained in step 2) to make "lightly hold into a ball and lightly press" "loose" soft material;

[0047] 4) the soft material prepared in step 3) is made into wet granules with a 14-mesh sieve;

[0048] 5) drying the wet granules prepared in step 4) a...

Embodiment 2-5

[0053] Compared with Example 1, the quality and preparation method of other raw materials are the same except that the quality of beef extract and D-(+)-lactose monohydrate is different.

[0054] The raw material formula of the marbofloxacin beef flavor sheet of embodiment 2-5 sees the following table 1:

[0055] Table 1 The raw material formula of the marbofloxacin beef flavor slice of embodiment 2-5

[0056]

[0057]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses marbofloxacin beef flavored tablets and a preparation method thereof; each 1000 slices of the flavored tablets are prepared from 20 g of marbofloxacin, 425-465 g of D-(+)-lactose monohydrate, 75 g of cross-linked povidone, 5 g of povidone K-30, 45-85 g of a beef extract, 4.8 g of silica, 6 g of magnesium stearate and 100 g of purified water as raw materials. The preparation method comprises the following steps: 1) preparing a mixed solution containing povidone K-30 and the beef extract; 2) preparing a soft material; 3) preparing wet particles; 4) drying; 5) screening and stabilizing the size; 6) adding silica and magnesium stearate into the size-stabilized particles in the step 5), and mixing evenly; and 7) pressing the particles mixed in the step 6) into drug tablets by using a tabletting machine. The flavored tablets are good in palatability and convenient to administrate, has quality meeting requirements of the Pharmacopoeia, and has treatment effects and side effects the same as those of other marbofloxacin tablets without addition of flavoring agents in markets. The preparation method is simple, the operation is convenient, and the preparation cost is low.

Description

technical field [0001] The invention relates to the technical field of antibiotics for dogs, in particular to a marbofloxacin beef-flavored tablet and a preparation method thereof. Background technique [0002] Marbofloxacin is a new type of fluoroquinolone antibacterial drug for animals. The antibacterial mechanism is mainly to inhibit bacterial DNA topoisomerase, thereby hindering the synthesis of bacterial DNA. Marbofloxacin has a broad antibacterial spectrum, has strong antibacterial activity against Gram-positive bacteria (especially Staphylococcus and Streptococcus), and has strong antibacterial activity against Gram-negative bacteria (Escherichia coli, Salmonella, Pasteurella, Klebsiella Bacteria, Proteus, Pseudomonas aeruginosa, Bordetella, Shigella, Haemophilus, Pseudomonas, Brucella) sensitive, also effective for mycoplasma, chlamydia, widely used in dogs against infection, currently No drug-resistant strains have been found. [0003] Marbofloxacin is administer...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K31/5395A61K47/46A61P31/04
CPCA61K9/2068A61K31/5395
Inventor 张卫元张可荣郭建云李应林唐万勇丁文格付列民刘洁李硕
Owner 湖北回盛生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap