Skin antibacterial transdermal liquid and preparation method thereof

Abstract

The invention relates to the technical field of medicines, in particular to skin antibacterial transdermal liquid and a preparation method thereof. The traditional Chinese medicine composition is prepared by mixing the following raw materials in percentage by weight: 0.1%-0.4% of radix euphorbiae lantu, 0.25%-0.75% of rhizoma smilacis glabrae, 0.15%-0.55% of honeysuckle flower, 0.08%-0.38% of radix salviae miltiorrhizae, 0.2%-0.8% of flos chrysanthemi indici, 0.05%-0.55% of spina gleditsiae, 0.05%-0.45% of typhonium giganteum, 3%-8% of borneol, 0.25%-0.6% of radix sophorae flavescentis, 0.2%-0.65% of fructus cnidii, 0.15%-0.45% of fructus kochiae, 0.01%-0.45% of radix stemonae and 0.02%-0.55% of chlorhexidine acetate. The skin antibacterial transdermal liquid has the beneficial effects that through the synergistic interaction of various natural traditional Chinese medicine components and the combination of a modern extraction process, effective components are fully reserved, the skin antibacterial transdermal liquid has a remarkable inhibition effect on various skin pathogenic bacteria such as staphylococcus aureus, escherichia coli and candida albicans, and the antibacterial rate can reach 90% or above; meanwhile, the traditional Chinese medicine is used for improving skin microcirculation, and penetration promoting components such as borneol are used, so that the medicine can quickly penetrate through the skin cuticle and penetrate into the skin tissue to exert the medicine effect, the symptoms such as skin itch and inflammation are effectively relieved, the preparation process is relatively simple, and industrial production is easy.

Description

Technical Field

[0001] The invention relates to the technical field of medicine, and in particular to a skin antibacterial transdermal solution and a preparation method thereof. Background Art

[0002] In daily life, people's skin is easily invaded by various bacteria and fungi, causing skin problems such as itching, redness, swelling, and rash. Traditional skin antibacterial preparations have poor antibacterial effects and difficulty in transdermal absorption, which makes it difficult for drugs to effectively reach the site of action and exert their effects, affecting the treatment process.

[0003] Therefore, it is of great significance to develop a skin medication with high antibacterial efficiency and good transdermal performance. Summary of the invention

[0004] In order to solve the problems raised in the above background technology, the object of the present invention is to provide a skin antibacterial transdermal solution and a preparation method thereof.

[0005] To solve the above technical problems, the technical solution provided by the present invention is: a skin antibacterial transdermal solution and a preparation method thereof, which is mixed with the following raw materials in weight ratio: 0.1%-0.4% of wolfsbane, 0.25%-0.75% of smilax glabra, 0.15%-0.55% of honeysuckle, 0.08%-0.38% of salvia miltiorrhiza, 0.2%-0.8% of wild chrysanthemum, 0.05%-0.55% of honeysuckle thorn, 0.05%-0.45% of unicorn herb, 3%-8% of borneol, 0.25%-0.6% of sophora flavescens, 0.2%-0.65% of cnidium monnieri, 0.15%-0.45% of kochia scoparia, 0.01%-0.45% of stemonae, and 0.02%-0.55% of chlorhexidine acetate.

[0006] Preferably, the weight ratio of the raw materials is: wolfsbane 0.2%-0.3%, smilax glabra 0.35%-0.6%, honeysuckle 0.2%-0.4%, salvia miltiorrhiza 0.15%-0.3%, wild chrysanthemum 0.4%-0.55%, Gleditsia sinensis 0.15%-0.3%, Smilax glabra 0.15%-0.25%, borneol 5%-7.5%, Sophora flavescens 0.3%-0.45%, Cnidium monnieri 0.4%-0.6%, Kochia scoparia 0.2%-0.35%, Stemona tuberosa 0.05%-0.25%, and chlorhexidine acetate 0.08%-0.45%.

[0007] Preferably, it is characterized in that the weight ratio of the raw materials is: 0.25% of wolfsbane, 0.5% of rhizoma smilacis Glabrae, 0.3% of honeysuckle, 0.2% of salvia miltiorrhiza, 0.5% of wild chrysanthemum, 0.25% of honeysuckle thorn, 0.2% of unicornia, 5% of borneol, 0.35% of sophora flavescens, 0.5% of cnidium monnieri, 0.25% of kochia scoparia, 0.2% of stemona, and 0.1%-0.3% of chlorhexidine acetate.

[0008] The method for preparing a skin antibacterial transdermal solution is characterized in that the raw materials of wolfsbane, smilax glabra, honeysuckle, salvia miltiorrhiza, wild chrysanthemum, Gleditsia sinensis, Herba Cynomorii, Borneolum, Sophora flavescens, Cnidium monnieri, Kochia scoparia, Stemona tuber, and chlorhexidine acetate are pretreated, extracted, mixed, prepared, and filtered.

[0009] Raw material pretreatment includes the following steps:

[0010] (1) Weigh prescribed weight portions of Stellera chamaejasme, Smilax glabra, Sophora flavescens, Cnidium monnieri, Kochia scoparia, and Stemona radix respectively, wash, dry, and grind into coarse powder for later use;

[0011] (2) Select honeysuckle, wild chrysanthemum, Chinese honeysuckle thorn, and unicorn lotus to remove impurities, rinse with clean water, and dry;

[0012] (3) Wash, slice and dry Salvia miltiorrhiza;

[0013] The extraction process consists of the following steps:

[0014] (1) taking the processed coarse powder of wolfsbane, smilax glabra, sophora flavescens, cnidium monnieri, kochia scoparia, and radix stemonae, placing them in a multifunctional extraction tank, adding 8-10 times the amount of water, soaking for 1-2 hours, heating to boiling, filtering, and collecting the filtrate; adding 6-8 times the amount of water to the residue, combining the filtrate, and concentrating under reduced pressure to form a medicine;

[0015] (2) taking honeysuckle, wild chrysanthemum, Gleditsia sinensis, and Herba Cynomorii, adding 6-8 times the amount of 70% ethanol, refluxing and extracting for 2-3 hours, filtering, and recovering ethanol from the filtrate until there is no alcohol taste, thereby obtaining an extract;

[0016] (3) adding 5-7 times the amount of 50% ethanol to the Danshen tablets, performing percolation extraction, collecting the percolation liquid, recovering the ethanol, and concentrating to an appropriate amount;

[0017] Mixing includes the following steps:

[0018] (1) The above-obtained medicament, extract and concentrate are mixed uniformly, borneol powder is added, stirred to dissolve, chlorhexidine acetate is added, stirred uniformly, and an appropriate amount of purified water is added;

[0019] Sterile filtration includes the following steps:

[0020] (1) The prepared liquid is sterilized and filtered through a 0.22 μm microporous filter membrane to obtain a finished product of a skin antibacterial transdermal solution.

[0021] Preferably, it is characterized in that after heating to boiling in the extraction step (1), the boiling is maintained for 2-3 hours.

[0022] Preferably, it is characterized in that the process of adding water to the Chinese medicinal residue in the extraction step (1) is repeated 1-2 times.

[0023] Preferably, it is characterized in that after adding ethanol in the extraction step (3), the mixture is immersed for 24 hours.

[0024] The beneficial effects of the present invention are:

[0025] The skin antibacterial transdermal solution of the present invention has a synergistic effect of multiple natural Chinese medicine ingredients and is combined with modern extraction technology to fully retain the effective ingredients. It has a significant inhibitory effect on multiple skin pathogens such as Staphylococcus aureus, Escherichia coli, Candida albicans, etc., and the antibacterial rate can reach more than 90%;

[0026] At the same time, traditional Chinese medicine is used to improve skin microcirculation and penetration-promoting ingredients such as borneol, so that the drug can quickly penetrate the skin stratum corneum and penetrate into the skin tissue to exert its efficacy, effectively relieving symptoms such as skin itching and inflammation. The preparation process is relatively simple and easy to industrialize.

[0027] Wolfsbane

[0028] Efficacy: expel water and expectorant, break up accumulation and kill insects. Mainly used to treat edema and abdominal distension, accumulation of phlegm, food and insects, heart and abdominal pain, chronic tracheitis, cough, asthma, tuberculosis of lymph nodes, skin, bones, epididymis, scabies, hemorrhoids and fistulas, etc.

[0029] Smilax glabra

[0030] Efficacy: detoxification, dehumidification, and joint unblocking. Used for limb cramps and muscle and bone pain caused by syphilis and mercury poisoning; damp-heat stranguria, leucorrhea, carbuncle, scrofula, scabies, etc.

[0031] honeysuckle

[0032] Efficacy: Clears away heat and detoxifies, dispels wind-heat. Used for carbuncle, furuncle, throat paralysis, erysipelas, dysentery caused by heat toxins, wind-heat cold, fever caused by febrile diseases, etc. It is a commonly used Chinese herbal medicine for clearing away heat and detoxifying;

[0033] Salvia miltiorrhiza

[0034] Efficacy: promote blood circulation and remove blood stasis, relieve menstruation and relieve pain, clear the heart and relieve restlessness, cool blood and eliminate carbuncle. Used for chest pain, abdominal pain, flank pain, accumulation of masses, heat pain, restlessness and insomnia, irregular menstruation, dysmenorrhea, amenorrhea, sores, swelling and pain, etc.

[0035] Wild Chrysanthemum

[0036] Efficacy: Clears away heat and detoxifies, purges fire and soothes the liver. Used for furuncle, carbuncle, red and swollen eyes, headache and dizziness, etc.

[0037] Gleditsia sinensis

[0038] Efficacy: Reduce swelling, expel toxins, drain pus, and kill insects. Used for carbuncle in its early stages or when pus has formed but has not yet ulcerated; external treatment for scabies, leprosy, etc.

[0039] Unicorn Lotus

[0040] Efficacy: dispel wind and phlegm, calm convulsions, detoxify and disperse knots, relieve pain. Used for stroke, phlegm congestion, facial paralysis, slurred speech, convulsions, epilepsy, tetanus, phlegm-induced headache, hemiplegia, scrofula, phlegm nodules, snake bites, etc.

[0041] Borneol

[0042] Efficacy: Invigorates the mind, clears away heat and relieves pain. Used for fever, coma, convulsions, stroke, phlegm, syncope, sudden syncope, coma, red eyes, mouth sores, sore throat, pus in the ear canal, etc.

[0043] Sophora flavescens

[0044] Efficacy: clearing away heat and dampness, killing insects, diuretic, used for heat dysentery, blood in stool, jaundice, urine retention, eczema, wet sores, itchy skin, scabies and leprosy;

[0045] Cnidium monnieri

[0046] Efficacy: Drying dampness and dispelling wind, killing insects and relieving itching, warming the kidney and strengthening yang, used for vaginal itching and leucorrhea, eczema itching, dampness and low back pain, kidney deficiency and impotence, uterine cold and infertility, etc.

[0047] Kochia scoparia

[0048] Efficacy: clearing away heat and dampness, dispelling wind and relieving itching, used for urinary difficulty, dripping and painful urination, rashes, eczema, skin itching, etc.

[0049] Baibu

[0050] Efficacy: moisturizes the lungs, relieves cough, kills insects and lice. Used for new and chronic coughs, tuberculosis coughs, whooping cough; externally used for head lice, body lice, pinworm disease, vaginal itching, etc.

[0051] Chlorhexidine acetate

[0052] Properties and uses: It is a disinfectant and preservative with a fairly strong broad-spectrum antibacterial and bactericidal effect, and is effective against both Gram-positive and Gram-negative bacteria.

[0053] Obviously, according to the above contents of the present invention, in accordance with common technical knowledge and customary means in the art, without departing from the above basic technical ideas of the present invention, other various forms of modification, replacement or change may be made.

[0054] The above contents of the present invention are further described in detail below through specific implementation methods in the form of embodiments. However, this should not be understood as the scope of the above subject matter of the present invention being limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. DETAILED DESCRIPTION

[0055] The present invention is described below with specific embodiments, but is not intended to be limiting of the present invention.

[0056] Embodiment 1: The raw materials are mixed by the following weight ratio: wolfsbane 0.2%-0.3%, smilax glabra 0.35%-0.6%, honeysuckle 0.2%-0.4%, salvia miltiorrhiza 0.15%-0.3%, wild chrysanthemum 0.4%-0.55%, Gleditsia sinensis 0.15%-0.3%, Smilax glabra 0.15%-0.25%, borneol 5%-7.5%, Sophora flavescens 0.3%-0.45%, Cnidium monnieri 0.4%-0.6%, Kochia scoparia 0.2%-0.35%, Stemona 0.05%-0.25%, chlorhexidine acetate 0.08%-0.45%.

[0057] Preferably, it is characterized in that the weight ratio of the raw materials is: 0.25% of wolfsbane, 0.5% of rhizoma smilacis Glabrae, 0.3% of honeysuckle, 0.2% of salvia miltiorrhiza, 0.5% of wild chrysanthemum, 0.25% of honeysuckle thorn, 0.2% of unicornia, 5% of borneol, 0.35% of sophora flavescens, 0.5% of cnidium monnieri, 0.25% of kochia scoparia, 0.2% of stemona, and 0.1%-0.3% of chlorhexidine acetate.

[0058] The method for preparing a skin antibacterial transdermal solution is characterized in that the raw materials of wolfsbane, smilax glabra, honeysuckle, salvia miltiorrhiza, wild chrysanthemum, Gleditsia sinensis, Herba Cynomorii, Borneolum, Sophora flavescens, Cnidium monnieri, Kochia scoparia, Stemona tuber, and chlorhexidine acetate are pretreated, extracted, mixed, prepared, and filtered.

[0059] Raw material pretreatment includes the following steps:

[0060] (1) Weigh prescribed weight portions of Stellera chamaejasme, Smilax glabra, Sophora flavescens, Cnidium monnieri, Kochia scoparia, and Stemona radix respectively, wash, dry, and grind into coarse powder for later use;

[0061] (2) Select honeysuckle, wild chrysanthemum, Chinese honeysuckle thorn, and unicorn lotus to remove impurities, rinse with clean water, and dry;

[0062] (3) Wash, slice and dry Salvia miltiorrhiza;

[0063] The extraction process consists of the following steps:

[0064] (1) taking the processed coarse powder of wolfsbane, smilax glabra, sophora flavescens, cnidium monnieri, kochia scoparia, and radix stemonae, placing them in a multifunctional extraction tank, adding 8-10 times the amount of water, soaking for 1-2 hours, heating to boiling, filtering, and collecting the filtrate; adding 6-8 times the amount of water to the residue, combining the filtrate, and concentrating under reduced pressure to form a medicine;

[0065] (2) taking honeysuckle, wild chrysanthemum, Gleditsia sinensis, and Herba Cynomorii, adding 6-8 times the amount of 70% ethanol, refluxing and extracting for 2-3 hours, filtering, and recovering ethanol from the filtrate until there is no alcohol taste, thereby obtaining an extract;

[0066] (3) adding 5-7 times the amount of 50% ethanol to the Danshen tablets, performing percolation extraction, collecting the percolation liquid, recovering the ethanol, and concentrating to an appropriate amount;

[0067] Mixing includes the following steps:

[0068] (1) The above-obtained medicament, extract and concentrate are mixed uniformly, borneol powder is added, stirred to dissolve, chlorhexidine acetate is added, stirred uniformly, and an appropriate amount of purified water is added;

[0069] Sterile filtration includes the following steps:

[0070] (1) The prepared liquid is sterilized and filtered through a 0.22 μm microporous filter membrane to obtain a finished product of a skin antibacterial transdermal solution.

[0071] Preferably, it is characterized in that after heating to boiling in the extraction step (1), the boiling is maintained for 2-3 hours.

[0072] Preferably, it is characterized in that the process of adding water to the Chinese medicinal residue in the extraction step (1) is repeated 1-2 times.

[0073] Preferably, it is characterized in that after adding ethanol in the extraction step (3), the mixture is immersed for 24 hours.

[0074] Embodiment 2: It is formed by mixing the following raw materials in weight ratio: wolfsbane 0.2%-0.3%, smilax glabra 0.35%-0.6%, honeysuckle 0.2%-0.4%, salvia miltiorrhiza 0.15%-0.3%, wild chrysanthemum 0.4%-0.55%, Gleditsia sinensis 0.15%-0.3%, Smilax glabra 0.15%-0.25%, borneol 5%-7.5%, Sophora flavescens 0.3%-0.45%, Cnidium monnieri 0.4%-0.6%, Kochia scoparia 0.2%-0.35%, Stemona 0.05%-0.25%, chlorhexidine acetate 0.08%-0.45%.

[0075] Preferably, it is characterized in that the weight ratio of the raw materials is: 0.25% of wolfsbane, 0.5% of rhizoma smilacis Glabrae, 0.3% of honeysuckle, 0.2% of salvia miltiorrhiza, 0.5% of wild chrysanthemum, 0.25% of honeysuckle thorn, 0.2% of unicornia, 5% of borneol, 0.35% of sophora flavescens, 0.5% of cnidium monnieri, 0.25% of kochia scoparia, 0.2% of stemona, and 0.1%-0.3% of chlorhexidine acetate.

[0076] The method for preparing a skin antibacterial transdermal solution is characterized in that the raw materials of wolfsbane, smilax glabra, honeysuckle, salvia miltiorrhiza, wild chrysanthemum, Gleditsia sinensis, Herba Cynomorii, Borneolum, Sophora flavescens, Cnidium monnieri, Kochia scoparia, Stemona tuber, and chlorhexidine acetate are pretreated, extracted, mixed, prepared, and filtered.

[0077] Raw material pretreatment includes the following steps:

[0078] (1) Weigh prescribed weight portions of Stellera chamaejasme, Smilax glabra, Sophora flavescens, Cnidium monnieri, Kochia scoparia, and Stemona radix respectively, wash, dry, and grind into coarse powder for later use;

[0079] (2) Select honeysuckle, wild chrysanthemum, Chinese honeysuckle thorn, and unicorn lotus to remove impurities, rinse with clean water, and dry;

[0080] (3) Wash, slice and dry Salvia miltiorrhiza;

[0081] The extraction process consists of the following steps:

[0082] (1) taking the processed coarse powder of wolfsbane, rhizoma smilax, sophora flavescens, fructus cnidii, fructus kochiae, and radix stemonae, placing them in a multifunctional extraction tank, adding 8-10 times the amount of water, soaking for 1-2 hours, heating to boiling, keeping slightly boiling for 2-3 hours, filtering, and collecting the filtrate; adding 6-8 times the amount of water to the residue, repeating the extraction 1-2 times, combining the filtrate, and concentrating under reduced pressure to obtain a medicine;

[0083] (2) taking honeysuckle, wild chrysanthemum, Gleditsia sinensis, and Herba Cynomorii, adding 6-8 times the amount of 70% ethanol, refluxing and extracting for 2-3 hours, filtering, and recovering ethanol from the filtrate until there is no alcohol taste, thereby obtaining an extract;

[0084] (3) adding 5-7 times the amount of 50% ethanol to the Danshen tablets, soaking for 24 hours, extracting by percolation, collecting the percolation liquid, recovering the ethanol, and concentrating to an appropriate amount;

[0085] Mixing includes the following steps:

[0086] (1) The above-obtained medicament, extract and concentrate are mixed uniformly, borneol powder is added, stirred to dissolve, chlorhexidine acetate is added, stirred uniformly, and an appropriate amount of purified water is added;

[0087] Sterile filtration includes the following steps:

[0088] (1) The prepared liquid is sterilized and filtered through a 0.22 μm microporous filter membrane to obtain a finished product of a skin antibacterial transdermal solution.

[0089] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0090] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

[0091] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A skin antibacterial transdermal solution, characterized in that: The invention is prepared by mixing the following raw materials in the following weight proportions: 0.1%-0.4% of wolfsbane, 0.25%-0.75% of rhizoma smilacis Glabrae, 0.15%-0.55% of honeysuckle, 0.08%-0.38% of salvia miltiorrhiza, 0.2%-0.8% of wild chrysanthemum, 0.05%-0.55% of thorn of gleditsia sinensis, 0.05%-0.45% of unicornia sinensis, 3%-8% of borneol, 0.25%-0.6% of sophora flavescens, 0.2%-0.65% of fructus cnidium, 0.15%-0.45% of fructus kochiae, 0.01%-0.45% of stemonae, and 0.02%-0.55% of chlorhexidine acetate.

2. The skin antibacterial transdermal solution according to claim 1, characterized in that: The weight ratio of the raw materials is: 0.2%-0.3% of wolfsbane, 0.35%-0.6% of rhizoma smilacis Glabrae, 0.2%-0.4% of honeysuckle, 0.15%-0.3% of salvia miltiorrhiza, 0.4%-0.55% of wild chrysanthemum, 0.15%-0.3% of gleditsia sinensis, 0.15%-0.25% of unicornia, 5%-7.5% of borneol, 0.3%-0.45% of sophora flavescens, 0.4%-0.6% of cnidium monnieri, 0.2%-0.35% of kochia scoparia, 0.05%-0.25% of stemonae, and 0.08%-0.45% of chlorhexidine acetate.

3. The antibacterial transdermal solution according to any one of claims 1 to 2, characterized in that: The weight ratio of the raw materials is: 0.25% of wolfsbane, 0.5% of smilax glabra, 0.3% of honeysuckle, 0.2% of salvia miltiorrhiza, 0.5% of wild chrysanthemum, 0.25% of honeysuckle thorn, 0.2% of unicornia, 5% of borneol, 0.35% of sophora flavescens, 0.5% of cnidium monnieri, 0.25% of kochia scoparia, 0.2% of stemonae, and 0.1%-0.3% of chlorhexidine acetate.

4. A method for preparing the antibacterial transdermal solution according to any one of claims 1 to 3, characterized in that: The raw materials of wolfsbane, smilax glabra, honeysuckle, salvia miltiorrhiza, wild chrysanthemum, thorn of honeysuckle, lotus root, borneol, sophora flavescens, cnidium monnieri, kochia scoparia, radix stemonae, and chlorhexidine acetate are pretreated, extracted, mixed, blended, and filtered. Raw material pretreatment includes the following steps: (1) Weigh prescribed weight portions of Stellera chamaejasme, Smilax glabra, Sophora flavescens, Cnidium monnieri, Kochia scoparia, and Stemona radix respectively, wash, dry, and grind into coarse powder for later use; (2) Select honeysuckle, wild chrysanthemum, Chinese honeysuckle thorn, and unicorn lotus to remove impurities, rinse with clean water, and dry; (3) Wash, slice and dry Salvia miltiorrhiza; The extraction process consists of the following steps: (1) taking the processed coarse powder of wolfsbane, smilax glabra, sophora flavescens, cnidium monnieri, kochia scoparia, and radix stemonae, placing them in a multifunctional extraction tank, adding 8-10 times the amount of water, soaking for 1-2 hours, heating to boiling, filtering, and collecting the filtrate; adding 6-8 times the amount of water to the residue, combining the filtrate, and concentrating under reduced pressure to form a medicine; (2) taking honeysuckle, wild chrysanthemum, Gleditsia sinensis, and Herba Cynomorii, adding 6-8 times the amount of 70% ethanol, refluxing and extracting for 2-3 hours, filtering, and recovering ethanol from the filtrate until there is no alcohol taste, thereby obtaining an extract; (3) adding 5-7 times the amount of 50% ethanol to the Danshen tablets, performing percolation extraction, collecting the percolation liquid, recovering the ethanol, and concentrating to an appropriate amount; Mixing includes the following steps: (1) The above-obtained medicament, extract and concentrate are mixed uniformly, borneol powder is added, stirred to dissolve, chlorhexidine acetate is added, stirred uniformly, and an appropriate amount of purified water is added; Sterile filtration includes the following steps: (1) The prepared liquid is sterilized and filtered through a 0.22 μm microporous filter membrane to obtain a finished product of a skin antibacterial transdermal solution.

5. The method for preparing a skin antibacterial transdermal solution according to claim 4, characterized in that: After heating to boiling in the extraction step (1), the mixture is kept at a slight boiling temperature for 2-3 hours.

6. The method for preparing a skin antibacterial transdermal solution according to claim 4, characterized in that: The extraction step (1) of adding water to the Chinese medicinal residue is repeated 1-2 times.

7. The method for preparing a skin antibacterial transdermal solution according to claim 4, characterized in that: In the extraction step (3), ethanol is added and then immersed for 24 hours.