Sterilization disinfectant and preparation method thereof

Abstract

The invention relates to the field of disinfectants, and particularly discloses a sterilization disinfectant and a preparation method thereof. The sterilization disinfectant is prepared from the following raw materials in parts by weight: 0.01 to 0.03 part of slow-release chlorhexidine acetate; and 0.82 to 0.84 part of 75% ethanol. The preparation method comprises the following steps: preparing slow-release chlorhexidine acetate; according to the proportion, the slow-release chlorhexidine acetate is mixed with 75% ethyl alcohol, the mixture is stirred to be uniform, and the sterilization and disinfection agent can be prepared. The sterilization disinfectant provided by the invention can be used for disinfecting hands, and has the advantages of improving the disinfection effect and prolonging the disinfection action time.

Description

Technical Field

[0001] This application relates to the field of disinfectants, and more specifically, it relates to a bactericidal disinfectant and its preparation method. Background Art

[0002] With the gradual increase in people's awareness of the importance of disinfection, the prevention and control of hospital infections has always been one of the important public health issues in the international medical community. Some countries have detailed regulations on the handwashing facilities, their locations, and the quantity of required items in hospitals, and have stipulated the situations in which medical staff and patients must wash their hands. Even in hospitals in advanced countries such as the United States and Japan, alcohol-based hand disinfectants are recommended as a method for the hand hygiene of medical staff. Therefore, the reasonable application of hand hygiene and disinfection in medical care is crucial for the prevention and control of hospital infections.

[0003] In hospitals, hand disinfection before ward medical care can prevent pathogens from invading the patient's body through the hands; during daily activities and in doctor-patient and nurse-patient interactions, when the hands are contaminated, hand disinfection can eliminate the original microorganisms to prevent transmission to others and also protect oneself.

[0004] Ethanol disinfectant usually uses a 75% ethanol solution, which can be used for hand skin disinfection. It can coagulate proteins, cause the death of microorganisms, kill bacterial vegetative forms, and destroy most lipophilic viruses. However, it has strong volatility, and the disinfection effect is easily greatly reduced after rapid volatilization. For places in hospital wards where there are many types of germs, high disinfection frequencies and requirements, ethanol disinfectants cannot meet the requirements. Therefore, a bactericidal disinfectant with a better disinfection effect and a longer disinfection action time is needed. Summary of the Invention

[0005] In order to improve the disinfection effect and extend the disinfection action time, this application provides a bactericidal disinfectant and its preparation method.

[0006] In the first aspect, this application provides a bactericidal disinfectant, adopting the following technical solution: A bactericidal disinfectant comprises the following raw materials in parts by weight: Sustained-release chlorhexidine acetate 0.01 - 0.03 parts; 75% ethanol 0.82 - 0.84 parts.

[0007] By adopting the above technical solution, the disinfection preparation composed of the compound of sustained-release chlorhexidine acetate and ethanol has no toxicity such as allergy or carcinogenicity. It has a quick and long-lasting bactericidal effect. After use, a uniform invisible disinfection barrier is formed on the skin surface, while taking into account breathability. It can not only inhibit the discharge of deep skin microorganisms but also resist the invasion of foreign microorganisms on the skin. Therefore, the effects of improving the disinfection effect and extending the disinfection action time are obtained.

[0008] Optionally, the chlorhexidine acetate is wrapped by a sustained-release shell to form sustained-release chlorhexidine acetate. The sustained-release shell includes polycarbonate-based polyurethane, polyacrylate, and polydimethylsiloxane. The weight ratio of chlorhexidine acetate, polycarbonate-based polyurethane, polyacrylate, and polydimethylsiloxane is 1:2:1:1.

[0009] By adopting the above technical solution, the chlorhexidine acetate is wrapped by the sustained-release shell, which can effectively reduce the chlorhexidine acetate carried away by the volatilization of ethanol. After the bactericidal disinfectant reaches the human hand, ethanol acts first for disinfection, and the chlorhexidine acetate is slowly released when the hand rubs the disinfectant to play a role, which improves the bactericidal and disinfecting effect and prolongs the bactericidal and disinfecting time. The sustained-release shell made of polycarbonate-based polyurethane, polyacrylate, and polydimethylsiloxane, with polycarbonate-based polyurethane and polyacrylate as the main components of the shell material, provides excellent mechanical strength and elasticity. Polydimethylsiloxane can help the sustained-release shell break and improve the flexibility and wettability of the shell material. Such a sustained-release shell can not only effectively protect the chlorhexidine acetate from premature release and maintain good physical stability during storage, but also quickly release the chlorhexidine acetate after the sustained-release shell is damaged. After the chlorhexidine acetate completes secondary disinfection, the damaged sustained-release shell material forms a protective film on the skin surface. This protective film not only has good air permeability, can reduce skin water loss, but also can reduce the re-invasion of viruses, bacteria, etc. Therefore, the sustained-release chlorhexidine acetate integrates the concept of disinfection and skin care, does not harm the skin, is comfortable and smooth, and can effectively disinfect.

[0010] Optionally, the preparation method of the sustained-release shell material is as follows: Dissolve polycarbonate-based polyurethane and polyacrylate in ethyl acetate respectively to form a polycarbonate-based polyurethane solution and a polyacrylate solution; mix the polycarbonate-based polyurethane solution and the polyacrylate solution, stir evenly to form a composite shell material solution; add polydimethylsiloxane to the composite shell material solution and stir until evenly dispersed to form a sustained-release shell material solution.

[0011] Optionally, the preparation method of the sustained-release chlorhexidine acetate is as follows: Dissolve chlorhexidine acetate in ethanol to form a chlorhexidine acetate solution; Slowly add the chlorhexidine acetate solution to the sustained-release shell material solution, stir to form a stable emulsion, add Tween 80 to the emulsion, and continue to stir until the emulsion is in a stable state. The weight part of Tween 80 is half of the weight of chlorhexidine acetate; Place the emulsion in a ventilated environment and let the ethyl acetate volatilize naturally to solidify the microcapsules; Centrifuge and separate the microcapsules, wash the microcapsules, and dry the microcapsules until constant weight to obtain the sustained-release chlorhexidine acetate. The particle size of the sustained-release chlorhexidine acetate is 3 - 8 μm.

[0012] By adopting the above technical solution, the control of the particle size of the microcapsules can effectively improve the action time and effect of the bactericidal disinfectant.

[0013] Optionally, the bactericidal disinfectant further includes a silver ion antibacterial agent and hydrogen peroxide. The weight portion of the silver ion antibacterial agent is 0.002 - 0.004 parts, and the weight portion of the hydrogen peroxide is 0.001 - 0.003 parts.

[0014] By adopting the above technical solution, hydrogen peroxide has a broad-spectrum bactericidal effect, can effectively expand the bactericidal and disinfection range of ethanol and chlorhexidine acetate, and the silver ion antibacterial agent can effectively improve the stability of hydrogen peroxide and play a catalytic role during the bactericidal and disinfection of hydrogen peroxide, improving its bactericidal and disinfection effect. In addition, the silver ion antibacterial agent can sterilize repeatedly and can effectively extend the action time of the bactericidal disinfectant.

[0015] Optionally, the bactericidal disinfectant further includes chitin, hyaluronic acid and grape seed oil. The weight portion of the chitin is 0.002 - 0.005 parts, the weight portion of the hyaluronic acid is 0.005 - 0.01 parts, and the weight portion of the grape seed oil is 0.003 - 0.005 parts.

[0016] By adopting the above technical solution, since hydrogen peroxide has extremely strong oxidizing property, even with a small addition amount, it may cause damage to the skin. Therefore, the following components are added: hyaluronic acid has excellent moisturizing and hydrating effects, can stabilize the skin barrier and slow down skin damage; chitin can adsorb harmful substances, repair damaged cells, accelerate cell regeneration and improve skin breathability; grape seed oil has a light texture and is easy to absorb, can effectively moisten the skin. The three are used in combination, can effectively reduce the damage of various disinfection components to the skin, protect the skin on the premise of effective disinfection, moisten the skin, and reduce the secondary harm of bacteria and viruses.

[0017] In the second aspect, the present application provides a preparation method of a bactericidal disinfectant, adopting the following technical solution: A preparation method of a bactericidal disinfectant includes the following steps: preparing slow-release chlorhexidine acetate; taking the slow-release chlorhexidine acetate and mixing it with 75% ethanol according to the ratio, and stirring until uniform to obtain the bactericidal disinfectant.

[0018] By adopting the above technical solution, the obtained bactericidal disinfectant has the advantages of extending the disinfection action time and improving the disinfection effect.

[0019] In the third aspect, the present application provides a preparation method of a bactericidal disinfectant, adopting the following technical solution: A preparation method of a bactericidal disinfectant includes the following steps: Prepare sustained-release chlorhexidine acetate; according to the ratio, take sustained-release chlorhexidine acetate, silver ion antibacterial agent and hydrogen peroxide and mix them with 75% ethanol, stir until uniform, and then a bactericidal disinfectant can be prepared.

[0020] Fourthly, the present application provides a preparation method of a bactericidal disinfectant, adopting the following technical solution: A preparation method of a bactericidal disinfectant includes the following steps: Prepare sustained-release chlorhexidine acetate; according to the ratio, take sustained-release chlorhexidine acetate, silver ion antibacterial agent, hydrogen peroxide, chitin, hyaluronic acid and grape seed oil and mix them with 75% ethanol, stir until uniform, and then a bactericidal disinfectant can be prepared.

[0021] In summary, the present application has the following beneficial effects: 1. Since the disinfection preparation of the present application is composed of the compound of sustained-release chlorhexidine acetate and ethanol, it has no allergies, no carcinogenic and other toxicities. It has a rapid and long-lasting bactericidal effect. After use, a uniform invisible disinfection barrier is formed on the skin surface, while taking into account breathability. It can not only inhibit the discharge of deep skin microorganisms, but also resist the invasion of foreign microorganisms on the skin.

[0022] 2. In the present application, a sustained-release shell made of polycarbonate-based polyurethane, polyacrylate and polydimethylsiloxane is preferably used. The sustained-release shell can not only effectively protect chlorhexidine acetate from premature release, so that it maintains good physical stability during storage, but also can quickly release chlorhexidine acetate after the sustained-release shell is damaged. After chlorhexidine acetate completes secondary disinfection, the damaged sustained-release shell material forms a protective film on the skin surface. This protective film not only has good breathability, can reduce skin water loss, but also can reduce the re-invasion of viruses, bacteria, etc. Therefore, the sustained-release chlorhexidine acetate integrates the concept of disinfection and skin care, does not harm the skin, is comfortable and smooth, and can effectively disinfect.

[0023] 3. The method of the present application has the advantages of prolonging the disinfection time and improving the disinfection effect for the prepared bactericidal disinfectant. Specific Embodiments

[0024] The following further elaborates the present application in detail with reference to embodiments. It should be specifically noted that: those without specific conditions in the following embodiments are carried out according to conventional conditions or conditions recommended by the manufacturer. The raw materials used in the following embodiments can be obtained from ordinary commercial sources unless otherwise specified.

[0025] Chlorhexidine acetate, CAS: 56-95-1, concentration 98%.

[0026] 75% ethanol, analytically pure.

[0027] Polycarbonate-based polyurethane, PCU, purchased from Dongguan Fulin Plastic Raw Material Co., Ltd.

[0028] Polyacrylate, brand: Nippon Shokubai.

[0029] Polydimethylsiloxane, food grade, brand: Guirunbao.

[0030] Silver ion antibacterial agent, brand: Jingao, particle size 10μm.

[0031] Chitin, CAS: 1398 - 61 - 4.

[0032] Hyaluronic acid, CAS: 9004 - 61 - 9, purchased from Xi'an Xinlu Biotechnology Co., Ltd.

[0033] Grape seed oil, CAS: 8024 - 22 - 4, purchased from Wuhan Runze Weiye Technology Co., Ltd.

[0034] Examples

[0035] Example 1

[0036] A bactericidal disinfectant, comprising the following raw materials in parts by weight: sustained - release chlorhexidine acetate 0.01 kg; 75% ethanol 0.84 kg.

[0037] The sustained - release chlorhexidine acetate is prepared by encapsulating chlorhexidine acetate with a sustained - release shell. The sustained - release shell comprises polycarbonate - based polyurethane, polyacrylate and polydimethylsiloxane. The weight ratio of chlorhexidine acetate, polycarbonate - based polyurethane, polyacrylate and polydimethylsiloxane is 1:2:1:1.

[0038] A preparation method of a bactericidal disinfectant, comprising the following steps: 1. Preparation of sustained - release chlorhexidine acetate: Preparation of the sustained - release shell material: Dissolve 2 kg of polycarbonate - based polyurethane in 25 L of ethyl acetate, stir until completely dissolved to form a uniform polycarbonate - based polyurethane solution. Dissolve 1 kg of polyacrylate in 25 L of ethyl acetate, stir until completely dissolved to form a uniform polyacrylate solution. Mix the polycarbonate - based polyurethane solution and the polyacrylate solution, stir evenly to form a composite shell material solution.

[0039] Add 1 kg of polydimethylsiloxane to the composite shell material solution, stir until the polydimethylsiloxane is completely and evenly dispersed in the composite shell material solution to form a sustained - release shell material solution for standby.

[0040] Dissolve 1 kg of chlorhexidine acetate in 10 L of ethanol, stir until completely dissolved to form a uniform chlorhexidine acetate solution.

[0041] Slowly add the chlorhexidine acetate solution to the slow-release shell material solution, stir at 10,000 rpm for 20 min to form a stable emulsion, add 0.5 kg of Tween 80 to the emulsion to improve the stability of the emulsion, and continue stirring until the emulsion is in a stable state.

[0042] Place the emulsion in a ventilated environment to allow ethyl acetate to volatilize naturally and cure the microcapsules; Centrifugation: Centrifuge at 5,000 rpm for 15 min to separate the microcapsules from the emulsion.

[0043] Washing: Wash the microcapsules with distilled water multiple times to remove the residual solvent and surfactant until the washing water is clear.

[0044] Dry the microcapsules until they reach a constant weight to obtain the slow-release chlorhexidine acetate, and control the particle size of the slow-release chlorhexidine acetate to be 3 μm.

[0045] 2. According to the ratio, take the slow-release chlorhexidine acetate and mix it with 75% ethanol, stir until homogeneous, and then the bactericidal disinfectant can be prepared.

[0046] Example 2

[0047] The difference between this example and Example 1 is that the dosages and specifications of each raw material are different, as shown in Table 1 for details.

[0048] Example 3

[0049] The difference between this example and Example 1 is that the dosages and specifications of each raw material are different, as shown in Table 1 for details.

[0050] Example 4

[0051] The difference between this example and Example 2 is that polyacrylate is used to replace polycarbonate-based polyurethane in the slow-release shell material.

[0052] Example 5

[0053] The difference between this example and Example 2 is that polycarbonate-based polyurethane is used to replace polyacrylate in the slow-release shell material.

[0054] Example 6

[0055] The difference between this example and Example 2 is that there is no polydimethylsiloxane in the slow-release shell material.

[0056] Example 7

[0057] The difference between this example and Example 2 is that polyacrylate is used to replace polycarbonate-based polyurethane in the slow-release shell material and there is no polydimethylsiloxane.

[0058] Example 8

[0059] The difference between this example and Example 2 is that in the slow-release shell material, polycarbonate-based polyurethane is used to replace polyacrylate, and there is no polydimethylsiloxane.

[0060] Example 9

[0061] The difference between this example and Example 2 is that the particle size of the slow-release chlorhexidine acetate is 1 μm.

[0062] Example 10

[0063] The difference between this example and Example 2 is that the particle size of the slow-release chlorhexidine acetate is 10 μm.

[0064] Example 11

[0065] The difference between this example and Example 2 is that the bactericidal disinfectant also includes a silver ion antibacterial agent and hydrogen peroxide. The addition amounts of the silver ion antibacterial agent and hydrogen peroxide are shown in Table 1 for details.

[0066] A preparation method of a bactericidal disinfectant includes the following steps: Prepare slow-release chlorhexidine acetate (the same as in Example 2).

[0067] According to the ratio, take the slow-release chlorhexidine acetate, the silver ion antibacterial agent and hydrogen peroxide and mix them with 75% ethanol, and stir until uniform to obtain the bactericidal disinfectant.

[0068] Example 12

[0069] The difference between this example and Example 11 is that the addition amounts of the silver ion antibacterial agent and hydrogen peroxide are different. See Table 1 for details.

[0070] Example 13

[0071] The difference between this example and Example 11 is that the addition amounts of the silver ion antibacterial agent and hydrogen peroxide are different. See Table 1 for details.

[0072] Example 14

[0073] The difference between this example and Example 12 is that there is no silver ion antibacterial agent.

[0074] Example 15

[0075] The difference between this example and Example 12 is that there is no hydrogen peroxide.

[0076] Example 16

[0077] The difference between this example and Example 12 is that the bactericidal disinfectant also includes chitin, hyaluronic acid and grape seed oil. The addition amounts of chitin, hyaluronic acid and grape seed oil are shown in Table 1 for details.

[0078] A preparation method of a bactericidal disinfectant includes the following steps: Prepare sustained-release chlorhexidine acetate (same as Example 2).

[0079] According to the ratio, take sustained-release chlorhexidine acetate, silver ion antibacterial agent hydrogen peroxide, chitin, hyaluronic acid and grape seed oil, and mix them with 75% ethanol, stir until uniform, then a bactericidal disinfectant can be prepared.

[0080] Example 17

[0081] The difference between this example and Example 16 lies in the different addition amounts of chitin, hyaluronic acid and grape seed oil. See Table 1 for details.

[0082] Example 18

[0083] The difference between this example and Example 16 lies in the different addition amounts of chitin, hyaluronic acid and grape seed oil. See Table 1 for details.

[0084] Example 19

[0085] The difference between this example and Example 17 is that there is no chitin in this example.

[0086] Example 20

[0087] The difference between this example and Example 17 is that there is no hyaluronic acid in this example.

[0088] Example 21

[0089] The difference between this example and Example 17 is that there is no grape seed oil in this example.

[0090] Example 22

[0091] The difference between this example and Example 17 is that there is no chitin and hyaluronic acid in this example.

[0092] Example 23

[0093] The difference between this example and Example 17 is that there is no hyaluronic acid and grape seed oil in this example.

[0094] Example 24

[0095] The difference between this example and Example 17 is that there is no chitin and grape seed oil in this example.

[0096] Table 1 Dosage and specifications of raw materials in each example

[0097] Control example

[0098] Control example 1 The bactericidal disinfectant is a 75% ethanol solution.

[0099] Comparative Example 2 The bactericidal disinfectant is prepared by mixing 0.02 kg of chlorhexidine acetate and 0.83 kg of 75% ethanol solution.

[0100] Performance testing Detection Methods

[0101] 1. On-site test of hand disinfection A total of 26 groups of bactericidal disinfectants were used as samples in the embodiments and comparative examples, and 10 samples were taken from each group.

[0102] On-site hand disinfection test: In a hospital ward, 78 medical staff, patients, and patient caregivers were randomly selected as subjects and divided into 26 groups, with 3 medical staff, 3 patients, and 3 patient caregivers in each group. Before disinfection, all subjects rubbed their hands together, put the five fingers of their left hand together, soaked a sterile cotton swab in a test tube containing 10ml of diluent, and squeezed it on the wall of the tube. Then, from the tip of the five fingers to the root of the finger, each finger was rubbed back and forth 2 times (rotate the cotton swab once for each rub) to collect samples. Then, the sampling end of the cotton swab was cut into the diluent test tube in a sterile manner as a positive control group sample.

[0103] The above-mentioned disinfectant samples were used to disinfect the five fingers of the right hand of the subjects from the fingertips to the bases using the above-mentioned method, and then the samples were collected. The sampling time was 30 seconds after disinfection, 15 minutes after disinfection, and 45 minutes after disinfection, as the test group samples. At the same time, the unused disinfectant samples, diluents and cotton swabs of the same batch were used as negative control group samples.

[0104] Take 1 ml of samples from the test group, positive control group and negative control group respectively, inoculate 2 plates with each sample by agar pouring method, place in a 37℃ constant temperature box for 48 hours, count the number of colonies, and calculate the sterilization rate. The test results show that there is no bacterial growth in the negative control group, so the test is effective. The average sterilization rate of each group of subjects after testing is shown in Table 2.

[0105] 2. Skin moisturizing effect test 26 groups of subjects with similar body characteristics were selected, with 3 subjects in each group. According to the daily hand washing method and habit, the subjects washed their right hands with water and dried them with a dryer for 100 s. The skin humidity of the central part of the back of the right hand of the initial subjects was tested with a skin humidity tester. Then, the bactericidal disinfectants prepared in different embodiments and comparative examples were used for disinfection. The skin humidity of the same part of the subjects at different times after disinfection was tested. The test results are shown in Table 2.

[0106] Table 2 Test results of disinfectants in various embodiments and comparative examples

[0107] Combined with Example 2, Comparative Example 1, and Comparative Example 2 and in conjunction with Table 2, it can be seen that the disinfection preparation prepared by compounding sustained-release chlorhexidine acetate and ethanol has a rapid and sustained bactericidal effect. Therefore, the effect of improving the disinfection effect and prolonging the disinfection time is obtained.

[0108] Combined with Example 2, Examples 4 to 8 and in conjunction with Table 2, it can be seen that when a sustained-release shell prepared by compounding polycarbonate-based polyurethane, polyacrylate, and polydimethylsiloxane is used to encapsulate chlorhexidine acetate, the disinfection effect is better and the disinfection time is longer.

[0109] Combined with Example 2, Examples 9 and 10 and in conjunction with Table 2, it can be seen that controlling the particle size of the sustained-release chlorhexidine acetate can effectively improve the disinfection effect and prolong the disinfection time.

[0110] Combined with Example 2 and Example 12 and in conjunction with Table 2, it can be seen that the addition of silver ion antibacterial agent and hydrogen peroxide further improves the disinfection effect and prolongs the disinfection time. And combined with Examples 14 and 15, it can be seen that when the two are compounded, the effect is the best.

[0111] Combined with Example 12 and Example 17 and in conjunction with Table 2, it can be seen that the addition of chitin, hyaluronic acid, and grape seed oil can effectively reduce the damage of various disinfection components to the skin, protect the skin on the premise of effective disinfection, and moisten the skin to reduce the secondary damage of bacteria and viruses. And combined with Examples 19 to 24, it can be seen that when the three are compounded and used, the effect is the best.

[0112] This specific embodiment is only an explanation of the present application, and it does not limit the present application. Those skilled in the art can make modifications without creative contributions to this embodiment after reading this specification, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A bactericidal disinfectant, characterized in that: The invention comprises the following raw materials in parts by weight: 0.01-0.03 parts of sustained-release chlorhexidine acetate; 0.82-0.84 parts of 75% ethanol.

2. A bactericidal disinfectant according to claim 1, characterized in that: The chlorhexidine acetate is wrapped by a sustained-release shell to form sustained-release chlorhexidine acetate, wherein the sustained-release shell comprises polycarbonate-based polyurethane, polyacrylate and polydimethylsiloxane, and the weight ratio of the chlorhexidine acetate, polycarbonate-based polyurethane, polyacrylate and polydimethylsiloxane is 1:2:1:

1.

3. A bactericidal disinfectant according to claim 2, characterized in that: The preparation method of the sustained-release shell material comprises: dissolving polycarbonate-based polyurethane and polyacrylate in ethyl acetate respectively to form a polycarbonate-based polyurethane solution and a polyacrylate solution; mixing the polycarbonate-based polyurethane solution with the polyacrylate solution, stirring evenly, to form a composite shell material solution; adding polydimethylsiloxane to the composite shell material solution, stirring until uniformly dispersed, to form a sustained-release shell material solution.

4. A bactericidal disinfectant according to claim 3, characterized in that: The preparation method of the sustained-release chlorhexidine acetate is: dissolving chlorhexidine acetate in ethanol to form a chlorhexidine acetate solution; Slowly adding the chlorhexidine acetate solution to the sustained-release shell material solution, stirring to form a stable emulsion, adding Tween 80 to the emulsion, and continuing to stir until the emulsion is in a stable state, wherein the weight of Tween 80 is half of the weight of the chlorhexidine acetate; The emulsion is placed in a ventilated environment to allow the ethyl acetate to evaporate naturally and solidify the microcapsules; The microcapsules are separated by centrifugation, washed, and dried until constant weight is obtained to obtain sustained-release chlorhexidine acetate, wherein the particle size of the sustained-release chlorhexidine acetate is 3 to 8 μm.

5. A bactericidal disinfectant according to claim 1, characterized in that: The bactericidal disinfectant further comprises a silver ion antibacterial agent and hydrogen peroxide, wherein the weight portion of the silver ion antibacterial agent is 0.002 to 0.004 parts, and the weight portion of the hydrogen peroxide is 0.001 to 0.003 parts.

6. A bactericidal disinfectant according to claim 5, characterized in that: The bactericidal disinfectant further comprises chitosan, hyaluronic acid and grape seed oil, wherein the weight portion of the chitosan is 0.002 to 0.005 parts, the weight portion of the hyaluronic acid is 0.005 to 0.01 parts, and the weight portion of the grape seed oil is 0.003 to 0.005 parts.

7. The method for preparing a bactericidal disinfectant according to any one of claims 1 to 4, characterized in that: The following steps are involved: Prepare sustained-release chlorhexidine acetate; according to the ratio, take the sustained-release chlorhexidine acetate and mix it with 75% ethanol, stir until it is uniform, and then the bactericidal disinfectant can be prepared.

8. The method for preparing a bactericidal disinfectant according to claim 5, characterized in that: The following steps are involved: Prepare sustained-release chlorhexidine acetate; according to the ratio, take the sustained-release chlorhexidine acetate, the silver ion antibacterial agent and hydrogen peroxide and mix them with 75% ethanol, stir until uniform, and then the bactericidal disinfectant can be prepared.

9. The method for preparing a bactericidal disinfectant according to claim 6, characterized in that: The following steps are involved: Prepare sustained-release chlorhexidine acetate; according to the proportion, take sustained-release chlorhexidine acetate, silver ion antibacterial agent hydrogen peroxide, chitin, hyaluronic acid and grape seed oil and mix with 75% ethanol, stir until uniform, and then the bactericidal disinfectant can be prepared.

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