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Biomarker for diagnosing white matter lesion and application thereof

A biomarker, white matter technology, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as unclear prediction and diagnosis of white matter lesions

Active Publication Date: 2021-06-29
BAO FENG BIOTECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unclear which substance can be clearly detected as the prediction and diagnosis of white matter lesions.

Method used

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  • Biomarker for diagnosing white matter lesion and application thereof
  • Biomarker for diagnosing white matter lesion and application thereof
  • Biomarker for diagnosing white matter lesion and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] sample

[0031] The model establishment sample group is 112 people, age range: over 45 years old, including 64 people in the control group and 48 people in the patient group.

[0032] The ratio of male to female in the control population was 1:1, and magnetic resonance imaging showed no abnormalities.

[0033] The male to female ratio in the patient population was 1:1, and magnetic resonance imaging showed infarcts in the white matter of the brain.

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Abstract

The invention provides a biomarker for diagnosing white matter lesion and application thereof. The biomarker is cholesterol-alpha-D-glucoside. The biomarker cholesterol-alpha-D-glucoside is combined with 6Z,9Z,20-eicosatrienoic acid, ceramide (m18:1(4E) / 24:1(15Z)), ephedrine A, cucurbitacine E, cholesteryl ester 22:6 or ceramide (d18:0 / 24:1(15Z)) to judge whether white matter lesion exists or not. The biomarker for diagnosing the white matter lesion is used for preparing a detection reagent for diagnosing the white matter lesion, and is beneficial for diagnosing whether the white matter lesion tends to exist or not and preventing the white matter lesion in advance.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a biomarker for diagnosing cerebral white matter lesions and an application thereof. Background technique [0002] White matter lesion (WML) is a common neurodegenerative disease, the most typical pathological manifestations are damage to the integrity of white matter or demyelination, which is common in stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, schizophrenia and many other diseases. White matter is an important part of the central nervous system, where nerve fibers gather. Damage to the myelin sheath of central nerve cells in white matter can cause white matter lesions. The typical response of white matter to various harmful stimuli is demyelination, which can be a secondary manifestation of neurological diseases such as infection, poisoning, degeneration, trauma, and lack of infarction. White matter lesions mainly cause sym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72
Inventor 陈显扬宋王婷张珂薛腾韩佳睿
Owner BAO FENG BIOTECH (BEIJING) CO LTD
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