Azilsartan tablet

An azilsartan tablet and tablet technology, applied in the field of medicine, can solve problems such as complicated process, unsuitable for long-term storage, and large amount of dust production

Active Publication Date: 2015-04-22
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of low-viscosity binders to improve the in vitro dissolution of azilsartan is often limited; Sartan is micronized to achieve this purpose, although the dissolution in vitro has been improved to a certain extent, but the process is complex and the amount of dust produced is large, which is not conducive to environmental protection and industrial production; Chinese patent CN102793680A discloses a solid dispersion of azilsartan The body

Method used

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  • Azilsartan tablet
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021] Preparation Process:

[0022] Dissolve 20g of azilsartan in 40g of diethylene glycol monoethyl ether, add 60g of povidone, stir to dissolve, then add 400g of fumed silica for adsorption, then mix with 100g of lactose, 30g of sodium carboxymethyl starch , 8g of magnesium stearate are uniformly mixed, and compressed by a direct compression process.

Embodiment 2

[0024]

[0025] Except that the substance added and consumption are different, other processing steps are the same as embodiment 1.

Embodiment 3

[0027]

[0028] Except that the substance added and consumption are different, other processing steps are the same as embodiment 1.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an azilsartan tablet. The azilsartan tablet contains azilsartan, hydroxy propyl cellulose and fumed silica, and is prepared by the following steps: dissolving the azilsartan and the hydroxy propyl cellulose in diethylene glycol monoethyl ether, adding the fumed silica to adsorb, uniformly mixing with pharmaceutically acceptable auxiliary materials and pressing by a direct tableting process. Compared with the prior art, the azilsartan tablet is high in drug dissolution speed and simple in process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an azilsartan tablet. Background technique [0002] Hypertension is a common type of cardiovascular and cerebrovascular diseases, and there are more than 1 billion hypertensive patients worldwide. The prevalence of hypertension in my country is also on the rise. It is estimated that there are currently 200 million hypertensive patients in the country. In the huge antihypertensive drug market, non-peptide angiotensin II (AngII) receptor inhibitors (ARB, referred to as "sartan") drugs have stable blood pressure reduction, good curative effect, long acting time, and patient tolerance. It has good properties, especially in preventing stroke, delaying renal insufficiency in diabetic and non-diabetic nephropathy, improving left ventricular hypertrophy, and protecting target organs. Since the entry of angiotensin II receptor antagonists (sartan) into the Chinese market, i...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4245A61P9/12
Inventor 张贵民徐志杰崔祥祯
Owner SHANDONG NEWTIME PHARMA
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