Composition capable of improving solubility and bioavailability of insoluble medicament

A technology for insoluble drugs and compositions, applied in the field of medicine, can solve problems such as poor oral absorption and poor water solubility, and achieve the effects of simple preparation method, good system stability, and wide application range

Inactive Publication Date: 2013-09-11
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its water solubility is

Method used

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  • Composition capable of improving solubility and bioavailability of insoluble medicament
  • Composition capable of improving solubility and bioavailability of insoluble medicament
  • Composition capable of improving solubility and bioavailability of insoluble medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 50g of soybean oil, add 3.5g of curcumin to dissolve the curcumin. Then weigh 25g of Labrasol and 25g of PEG 400, add them into the above-mentioned curcumin solution, and mix evenly until a uniform transparent solution is obtained.

Embodiment 2

[0038] Take ethyl oleate 40g, add curcumin 3.5g, make curcumin dissolve. Then weigh 40g of Tween 80 and 20g of Transcutol, add them into the above-mentioned curcumin solution, and mix evenly until a uniform transparent solution is obtained.

Embodiment 3

[0040] Weigh 15 g of linoleic acid and add 3.5 g of curcumin to dissolve the curcumin. Then weigh 60 g of Tween 80 and 25 g of glycerin, add them into the above-mentioned curcumin solution, and mix evenly until a uniform transparent solution is obtained.

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PUM

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Abstract

The invention belongs to the technical field of medicaments, and relates to a composition capable of improving the solubility and the bioavailability of an insoluble medicament. The composition consists of an oil phase, an emulsifier and a coemulsifier, wherein the oil phase, the emulsifier and the coemulsifier have the specific composition ratio range of 1: (0.5 to 4): (0.5 to 3). According to the composition, the hydrophobic property of the medicament can be improved, the oral absorbability of the medicament can be improved, and meanwhile, the medicament can be protected by a formed nano shell barrier, so that the medicament is separated from an external environment temporarily, and the degradation and the transformation of the medicament caused by external environment factors are avoided; and therefore, the residence time and the action time of the medicament in vivo can be prolonged, and the bioavailability of the medicament is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition capable of improving the bioavailability of poorly soluble drugs and a preparation method thereof. Background technique [0002] The biopharmaceutical classification system (BCS, biopharmaceutics classification system) divides drugs into 4 groups according to their solubility and permeability characteristics: highly soluble and highly permeable drugs belong to BCS classification Ⅰ; low soluble and highly permeable drugs belong to BCS Class II; highly soluble and low permeable drugs belong to BCS Class III; low soluble and low permeable drugs belong to BCS Class IV. Among the drugs under research and development, nearly 40% of potential new drugs are poorly water-soluble drugs, that is, BCS Ⅱ and Ⅳ drugs, which have poor absorption and low bioavailability, thus limiting their further clinical application[Lipinski , C. A. (2002). Poor Aqueous Solubility-An Industry Wide Pro...

Claims

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Application Information

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IPC IPC(8): A61K47/44A61K47/34A61K47/14A61K47/12A61K47/10A61K47/20
Inventor 杨丽唐晓娇袁丹
Owner SHENYANG PHARMA UNIVERSITY
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