The invention discloses a coal and uranium coordinated mining perspective physical simulation device and application method. The coal and uranium coordinated mining perspective physical simulation device is provided with a coal mining mechanism, a uranium mining mechanism and a observing mechanism, wherein the coal mining mechanism is provided with an organic glass box, a front panel, a rear panel, a bottom panel, a top panel, a left panel, a right panel, a strip-shaped water bag, a transporting pipe, a valve, a beaker, transparent soil, a press machine pressing head and small holes; the uranium mining mechanism is provided with positive pressure pumps, negative pressure pumps, a tracer agent, a liquid storing tank, conduits, an electric wire, a liquid injecting hole, a liquid pumping holeand a centralized control table; and the observing mechanism is provided with an industrial camera and a line laser generator. According to the coal and uranium coordinated mining perspective physical simulation device and application method, the volume of the strip-shaped water bag is adjusted to simulate coal seam mining, the positive pressure pumps are adopted to internally inject the tracer agent into the transparent soil to simulate uranium mine in-situ leaching mining, the mechanisms are matched closely, a multi-field coupling evolution law of coal and uranium coordinated mining is obtained, a coal and uranium coordinated mining scheme is optimized, and the recovery rate and economic benefits of co-associated resources are improved.