25 results about "Tissue oxygen" patented technology

The invention relates to the field of rehabilitation instruments, in particular to an intelligent pneumatic hand function rehabilitation training system which comprises a flexible exoskeleton glove provided with a pneumatic muscle array and used for assisting fingers of a user in grasping training. The fingertip position of the glove is connected with a magnetorheological damper through a flexible cable, and the magnetorheological damper is used for providing dynamic resistance in the training process. The electrical stimulation module is used for activating hand muscle groups in a targeted manner through a surface electrode and enhancing neuromuscular control; the sensor module is used for collecting physiological data of a user in real time; the physiological data comprises electromyographic signals and tissue blood oxygen saturation; the control unit is used for switching training modes, by means of the intelligent air pressure hand function rehabilitation training system, the training intensity can be matched with the real-time ability of a patient all the time, and the rehabilitation training effect is improved.

The invention provides a stepped air bag control method for preventing venous thrombosis based on infrared detection, and relates to the technical field of medical instrument control, and the method comprises the steps: obtaining the tissue oxygen saturation of at least one monitoring point of a target limb of a target user through a near-infrared sensor; when the target user is a hemiplegic individual, determining a control parameter of the stepped air bag according to the tissue oxygen saturation, and controlling the stepped air bag worn by the target limb to work according to the control parameter, so that the tissue oxygen saturation of the target limb reaches a preset state; the tissue oxygen saturation difference value of the hemiplegic side lower limb and the healthy side lower limb of the target user is smaller than a preset balance threshold value. According to the method provided by the invention, the stepped air bag can be dynamically controlled according to the real-time blood circulation state of the individual, the suitability, the real-time performance and the safety of venous thrombosis prevention of the limbs of the paralyzed individual are improved, and the use requirements of different individuals are met.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a traditional Chinese medicine compound antibacterial gel for promoting blood circulation to remove meridian obstruction and a preparation method thereof. The traditional Chinese medicine compound antibacterial gel for promoting blood circulation to remove meridian obstruction is prepared from the following components in percentage by mass: 0.01 to 0.03 percent of benzalkonium chloride, 0.02 to 0.05 percent of aromatic phenol acetate, 1 to 2.5 percent of propylene glycol, 0.01 to 0.05 percent of menthol, 0.3 to 0.6 percent of traditional Chinese medicine extracting solution, 0.01 to 0.05 percent of ginger root oil, 0.5 to 1 percent of pandan butyl ether, 0.01 to 0.05 percent of borneol, 0.3 to 5 percent of modified hydroxyethyl cellulose and the balance of water. The gel can relieve tissue edema and improve microcirculation and tissue oxygen supply; meanwhile, by combining with antibacterial components, the anti-infection effect can be synchronously achieved, the effects and advantages of promoting blood circulation and dredging collaterals of the traditional Chinese medicine compound are complementary, the better treatment effect is achieved, and the wound healing quality and speed are improved.

In some examples, determining a heart failure status includes using an implantable medical device configured for subcutaneous implantation and comprising a plurality of electrodes and an optical sensor. Processing circuitry of a system comprising the device may determine, for a patient, a current tissue oxygen saturation value based on a signal received from the at least one optical sensor, a current tissue impedance value based on a subcutaneous tissue impedance signal received from the electrodes, and a current pulse transit time value based on a cardiac electrogram signal received from the electrodes and at least one of the signal received from the optical sensor and the subcutaneous tissue impedance signal. The processing circuitry may further compare the current tissue oxygen saturation value, current tissue impedance value, and current pulse transit time value to corresponding baseline values, and determine the heart failure status of the patient based on the comparison.

An oxygen saturation measuring apparatus capable of measuring arterial blood oxidation saturation (SpO2), and tissue oxy- gen saturation (rSO2), safely, easily and economically at a desired po- sition of a biological body for a long time continuously. A ROM stores the distance information between a light emitting unit and a light re- ceiving unit situated corresponding to the depth of a target intended to be measured for tissue oxygen saturation, a light emission driving unit makes the light emitting unit emit light in an amount of light cor- responding to the distance information, MPU makes the light emitting unit emit a pulses capable of measuring the tissue oxygen saturation, MPU applies pulse capable of measuring the tissue oxygen saturation from the light emission driving unit to the light emitting unit, and the pulse increasing unit increases the amount of pulses from MPU for a predetermined time to pulses capable of measuring the arterial blood oxygen saturation.

When the oxygen isolation type photodynamic therapy device is used, the light-transmitting oxygen isolation type equipment covers the skin lesion surface of a patient to form an oxygen isolation layer, the tissue oxygen concentration of the epidermal layer and the dermal superficial layer of the patient can be reduced, and therefore the singlet oxygen photochemical generation rate of the area is reduced, and the photodynamic therapy effect is improved. The level of photochemical pain reaction caused by singlet oxygen during treatment of a patient is reduced; meanwhile, the method is cooperated with a light modulation technology, so that the singlet oxygen accumulation damage ratio of the targeted tissue and the non-targeted tissue can be further improved. Meanwhile, target cells of the erythema are located on capillary walls, target cells of skin precancerous lesions are located near a basal layer, and the oxygen concentration of the places is higher than that of an epidermal layer, so that the target selectivity of photodynamic therapy can be improved; the material can be used for hypoxia photodynamic therapy of nevus flammeus, skin precancerous lesions and other skin diseases.

The invention provides a Pt / PEDOT composite modified carbon-based material needle-shaped electrode in-vivo dissolved oxygen electrochemical sensor as well as a construction method and application thereof, and belongs to the technical field of medical biology. According to the in-vivo dissolved oxygen electrochemical sensor, a carbon-based material microneedle type electrode is modified by electrochemical deposition of platinum nanoparticles by using a chloroplatinic acid hexahydrate solution and depending on a time current method, and poly (3, 4-ethylenedioxythiophene) is generated by direct electro-polymerization on the surface of the Pt-modified microneedle electrode through an electrochemical constant current method. And forming uniform PEDOT (poly (3, 4-ethylenedioxythiophene)) film coated and modified platinum nanoparticles on the microneedle electrode. The composite modified carbon-based material is used for replacing precious metal to reduce cost and improve biocompatibility, low-oxygen sensitivity is optimized by means of composite modification, in-vivo protein adsorption and biological membrane coverage are resisted through anti-pollution surface modification, and therefore the defects are overcome, and monitoring of in-vivo tissue oxygen partial pressure is achieved.

A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.

The invention relates to the technical field of medical monitoring, in particular to a multi-source data integration grading early warning method and system for hand surgery vascular crisis. The invention discloses a multi-source data integration grading early warning method for hand surgery vascular crisis. The method comprises the following steps: S1, synchronously collecting tissue oxygen saturation, an original and uninjured side temperature difference value, behavioral environment data and clinical auxiliary data of a sentinel area through a multi-source sensor; s2, establishing a behavior recognition algorithm model, recognizing interference behaviors of the patient in real time based on the collected behavior environment data, and quantifying the interference behaviors to obtain influence data; and S3, based on the influence data, carrying out dynamic correction on the original and uninjured side temperature difference value to obtain a corrected and uninjured side temperature difference value, and carrying out dynamic correction on the tissue oxygen saturation to obtain the corrected tissue oxygen saturation. Through multi-source data fusion and intelligent correction, interference of patient behaviors and environmental factors on monitoring data can be effectively recognized and filtered out.

The application discloses a photosensitizer and tissue oxygen synchronous measurement device, and belongs to the technical field of photoelectric measurement. The application uses a semiconductor diode laser as an excitation source, the emission wavelength of which is determined according to the absorption characteristics of oxygen sensing material and photosensitizer, a laser beam is coupled into a detection optical fiber to form excitation light through optical components, so that the excitation light can excite the oxygen sensing material and the photosensitizer at the same time, the oxygen sensing material with near-infrared emission is used, the phosphorescence emission wavelength of which is far away from the fluorescence of the photosensitizer, the spectral intensity of near-infrared is used to determine the tissue oxygen concentration, the spectral intensity of red light is used to determine the concentration of the photosensitizer, in addition, the fluorescence and phosphorescence of the oxygen probe are both oxygen-dependent, so that the fluorescence intensity of the oxygen probe in the red light region can be accurately removed, thereby avoiding the influence of the fluorescence intensity of the oxygen probe on the detection of the photosensitizer fluorescence, and then realizing that the fluorescence for characterizing the photosensitizer concentration and the phosphorescence for characterizing the oxygen concentration are not overlapped, and realizing the synchronous measurement of the photosensitizer and the tissue oxygen.

The application discloses a kind of local tissue oxygen saturation detection systems for postoperative free flap, including front-end flexible detection module and rear-end signal processing module;Front-end flexible detection module includes the flexible packaging layer of flexible material and the interface layer of being arranged on packaging layer, the material of interface layer is hydrogel mixture, and the detection circuit for being encapsulated in packaging layer is used to detect the blood oxygen saturation of human tissue;Rear-end signal processing module is connected with the front-end flexible detection module, and the rear-end signal processing module processes the signal detected by the front-end flexible detection module, and the local tissue oxygen saturation information is obtained by calculating detection signal.This application is all designed with flexibility, avoids the mechanical damage of detection part to measurement site, so that the sensing part can better adhere to the surface of human skin, improve the accuracy of measurement and the comfort of patient.

An oximeter probe includes a probe unit or a base unit and a probe tip where the probe tip has a number of sources and detectors that can be accessed individually or in differing combinations for measuring tissue oxygen saturation at different tissue depth in tissue. A processor of the oximeter probe controls a multiplexer that is coupled to the detectors for selectively collecting measurement information from the detectors via the multiplexer. The oximeter probe is user programmable via one or more input devices on the oximeter probe for selecting the particular sources and detectors to collect measurement information from by the processor.

A multi-analyte sensor system is disclosed that includes a sensor probe with a first set of electrodes that transduce choline into electrical signals and a second set of electrodes that transduce tissue oxygen into electrical signals. The sensor probe includes a third set of electrodes that provide working and counter electrode functionality for the first and second set of electrodes. The system also has an electronics module interfaced with the sensor probe that includes a transceiver to transmit sensor data. The system further includes control circuitry that determines a choline state based on the first set of electrodes and determines a tissue oxygen state based on the second set of electrodes. The control circuitry is also configured to initiate an alarm condition based on one or more signals from the first and second set of electrodes.

The invention provides a critical patient skin failure early warning system based on tissue oxygen saturation monitoring, and relates to the field of medical monitoring and intelligent early warning. The system comprises a monitoring module, a data processing module, an early warning module and a display module. Skin tissue oxygen saturation, microcirculation blood flow parameters and temperature and humidity data are collected in real time through a non-invasive sensor, noise processing is conducted on the collected data through Kalman filtering, a risk value is calculated based on a multi-parameter fusion model, and dynamic risk assessment and graded early warning of skin failure are achieved. The system also optimizes a weight coefficient through machine learning, improves the sensitivity and specificity of an early warning model, supports remote data transmission and cloud analysis, and meets the requirements of bedside real-time monitoring and large-scale data analysis. The accuracy and timeliness of skin failure early recognition can be remarkably improved, scientific support is provided for treatment of critical patients, and the method has the advantages of being high in portability and adaptability and is suitable for ICU, emergency departments and other scenes.

The invention discloses a hemostasis clamping control method and system for a cardiovascular minimally invasive surgery, and relates to the technical field of cardiovascular minimally invasive surgeries, and the method comprises the steps: 1, collecting an image through a 4k endoscope, extracting a bleeding point region through a U-Net + + segmentation model, and recognizing a bleeding type through the combination of HOG features and an SVM classifier; 2, setting an initial opening degree through a displacement sensor, and adjusting a clamping angle by referring to the diameter of the blood vessel; thirdly, the electric clamping tool is started, the actual clamping force is fed back through a pressure sensor, and the rotating speed of a motor is dynamically adjusted to control the clamping force error; fourthly, the blood flow velocity is calculated through an optical flow method, tissue oxygen supply is monitored by combining a blood oxygen saturation sensor and a blood oxygen saturation sensor, and whether hemostasis succeeds or not is judged; 5, switching to a constant force maintaining mode after hemostasis succeeds, and reducing the clamping force according to the speed gradient after the operation is finished. The hemostasis control precision and stability are improved, the safety protection mechanism is perfected, the adaptability and practicability of the system are enhanced, and the clinical value is remarkable.

This invention relates to the field of medical device technology and discloses an intestinal mucosal tissue oxygen saturation monitoring device, comprising a monitor body, a catheter, a balloon, a near-infrared spectral emission and detection device, a lead wire, an inflation tube, an inflation device, a partition, and tubing one and tubing two. This invention can be used to directly, objectively, and continuously assess changes in small intestinal mucosal microcirculation and tissue oxygen consumption, and can be applied in various clinical environments. Furthermore, it is based on jejunal catheter placement technology, a mature and technically simple technique that can be performed bedside and is suitable for use in primary hospitals and general wards.

The invention provides a control method of a device for preventing deep venous thrombosis of lower limbs based on infrared detection, and relates to the technical field of medical instrument control. Tissue oxygen saturation and blood flow velocity of at least one monitoring point of the lower limbs of a target user are obtained through a near-infrared sensor; according to the tissue oxygen saturation and the blood flow velocity of the at least one monitoring site, determining the lower limb deep vein thrombosis risk level of the target user; determining intervention parameters of the target user according to the lower limb deep vein thrombosis risk level of the target user, wherein the intervention parameters comprise a dorsiflexion angle, a dorsiflexion frequency, a plantar flexion angle, a plantar flexion frequency and movement duration of an ankle joint; and controlling the lower limb deep vein thrombosis prevention device worn by the target user according to the intervention parameters of the target user. According to the method, the intervention parameters of the device for preventing the deep venous thrombosis of the lower limbs can be dynamically adjusted, so that the defects of the existing device for preventing the deep venous thrombosis of the lower limbs in adaptability, scene coverage and intervention effect are overcome.

The invention discloses a self-adaptive dynamic tourniquet tightness control method for trauma first aid, relates to the technical field of tightness control, aims to solve the problems of insufficient hemostasis regulation and control precision and poor individualized adaptability, and provides a self-adaptive dynamic tourniquet tightness control method for trauma first aid by setting initial hemostasis alarm time and collecting arterial pulse amplitude and oxyhemoglobin saturation of a tourniquet contact area in real time. Calculating a blood flow passing characteristic according to the pulse amplitude, evaluating a local blood flow state, analyzing a tissue oxygen supply state based on the oxyhemoglobin saturation, carrying out standardization and weighted summation on the blood flow passing characteristic and the tissue oxygen supply state to generate a hemostasis evaluation coefficient, and carrying out dynamic correction on initial alarm time to obtain actual alarm time. The local pressure value and the blood flow speed are monitored within the time, whether the tourniquet is loosened or not is judged, the blood flow reperfusion time and the microcirculation perfusion density are detected during loosening, the loosening amplitude is comprehensively calculated, whether monitoring continues or hemostasis is stopped or not is determined, and therefore the hemostasis regulation and control precision is improved.

The invention provides a skin soft tissue pressure injury early warning system for orthopedic trauma nursing, and relates to the technical field of orthopedic nursing. A sensing monitoring module is arranged to monitor the temperature of the contact surface of an orthopedic fixing device and skin and the tissue oxygen saturation degree at the same time; the control processing module carries out trend analysis on the temperature and the tissue oxygen saturation, the control processing module generates a pressure reduction control instruction according to a trend analysis result or a pain trigger signal sent by the pain feedback module, and the inflation pressure reduction module controls the micro air bags at the corresponding positions to execute fixed-point deflation pressure reduction. Passive monitoring and passive adjustment are achieved through the sensing monitoring module, the control processing module and the inflation pressure reduction module, and active feedback and pressure reduction adjustment are achieved through the pain feedback module, the control processing module and the inflation pressure reduction module.

The invention provides an imaging method and system, a storage medium and computing device.The method comprises the steps that an oxygen-sensitive film which is prepared in advance and provided with an oxygen-sensitive probe is installed on to-be-detected tissue of a to-be-detected object; the to-be-detected tissue contains specific tissue cells sensitive to calcium signals; alternately irradiating the multiple types of exciting light on the to-be-detected tissue according to a target interval through the imaging path; according to the target interval, different cameras are used for continuously collecting all frames of first exciting light signals on the oxygen sensitive film, all frames of second exciting light signals of the specific tissue cells and all frames of reflected light signals of blood oxygen in the tissue to be detected; generating a tissue oxygen partial pressure image of the to-be-detected tissue according to the continuously collected frames of first excitation light signals, generating a calcium signal image of the to-be-detected tissue according to the continuously collected frames of second excitation light signals, and generating a blood oxygen signal image of the to-be-detected tissue according to the continuously collected frames of reflected light signals.

The invention relates to the technical field of cardiovascular surgery, and particularly discloses a method for predicting delirium after non-extracorporeal circulation coronary artery bypass surgery based on preoperative tissue oxygen saturation. Selecting a patient of which the age is greater than or equal to 60 years old and which is planned to be subjected to the selected non-extracorporeal circulation coronary artery bypass transplantation as a subject; the blood vessel or tissue of a patient does not need to be punctured, the risks of pain, infection and the like caused by invasive examination are avoided, and the comfort level and acceptability of the patient are improved; changes of tissue oxygen saturation can be continuously monitored in real time, oxygen supply balance abnormity of a patient can be found in time, and timely information is provided for clinical intervention; equipment operation is relatively simple, complex technical training is not needed, medical staff can rapidly master the using method, and wide clinical application is facilitated; the method is suitable for patients of different age groups and different illness states, and especially has important application value for some patients who cannot tolerate invasive examination.

A circulatory device for maintenance of tissue oxygen levels in a subject includes a first conduit for fluid to flow into the device, a second conduit for fluid to flow out of the device. an oxygenator device, an oxygenator control unit, at least one fluid flow sensor, a flow control unit which provides input to the flow control element, and a flow control element configured to accept a variable input to modify the rate of fluid flow into and out of the device, and at least one tissue oxygen sensor. The device is affixed removably to the body of an individual.

A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.

The utility model provides a kind of tissue oxygen saturation micro monitoring probe, the utility model relates to severed finger replantation blood supply monitoring technical field, tissue oxygen saturation micro monitoring probe, comprising: probe body, two groups of optical fiber components are built-in in probe body, optical fiber component is used for light out and light in, and two pieces of astigmatism lens one and two pieces of condenser lens one are sealedly installed on the surface of probe body by opening, and astigmatism lens one and condenser lens one are respectively corresponding with the light outlet end, light inlet end of optical fiber component;Connecting wire, chip is built-in in connecting wire;The utility model has the beneficial effect that: it solves the existing probe due to wrapping sheet larger and influence postoperative observation;Emitting part and photoelectric detection device are burned after energization due to continuous light emission and heat and cause skin burn;And as well as the problem of high cost of probe use.

The invention relates to the field of biological medicine, and discloses application of urine-derived stem cells in ED treatment. According to the scheme, a 9-copy hypoxia response element, a minimum promoter, a vascular endothelial growth factor and a nerve growth factor gene are introduced into urine-derived stem cells by utilizing a lentiviral vector, and a hypoxia response type gene modified cell system is constructed. Through local injection of the cavernous body, the cells accurately start factor expression in an anoxic microenvironment. According to the invention, deep coupling of vascular regeneration and neural restoration can be realized, expression can be automatically reduced along with rising of tissue oxygen content, excessive hyperplasia complications can be avoided, and closed-loop intelligent treatment of pathological induction-precise intervention can be realized.