11 results about "Tissue oxygen" patented technology

An oxygen saturation measuring apparatus capable of measuring arterial blood oxidation saturation (SpO2), and tissue oxy- gen saturation (rSO2), safely, easily and economically at a desired po- sition of a biological body for a long time continuously. A ROM stores the distance information between a light emitting unit and a light re- ceiving unit situated corresponding to the depth of a target intended to be measured for tissue oxygen saturation, a light emission driving unit makes the light emitting unit emit light in an amount of light cor- responding to the distance information, MPU makes the light emitting unit emit a pulses capable of measuring the tissue oxygen saturation, MPU applies pulse capable of measuring the tissue oxygen saturation from the light emission driving unit to the light emitting unit, and the pulse increasing unit increases the amount of pulses from MPU for a predetermined time to pulses capable of measuring the arterial blood oxygen saturation.

When the oxygen isolation type photodynamic therapy device is used, the light-transmitting oxygen isolation type equipment covers the skin lesion surface of a patient to form an oxygen isolation layer, the tissue oxygen concentration of the epidermal layer and the dermal superficial layer of the patient can be reduced, and therefore the singlet oxygen photochemical generation rate of the area is reduced, and the photodynamic therapy effect is improved. The level of photochemical pain reaction caused by singlet oxygen during treatment of a patient is reduced; meanwhile, the method is cooperated with a light modulation technology, so that the singlet oxygen accumulation damage ratio of the targeted tissue and the non-targeted tissue can be further improved. Meanwhile, target cells of the erythema are located on capillary walls, target cells of skin precancerous lesions are located near a basal layer, and the oxygen concentration of the places is higher than that of an epidermal layer, so that the target selectivity of photodynamic therapy can be improved; the material can be used for hypoxia photodynamic therapy of nevus flammeus, skin precancerous lesions and other skin diseases.

The invention provides a Pt / PEDOT composite modified carbon-based material needle-shaped electrode in-vivo dissolved oxygen electrochemical sensor as well as a construction method and application thereof, and belongs to the technical field of medical biology. According to the in-vivo dissolved oxygen electrochemical sensor, a carbon-based material microneedle type electrode is modified by electrochemical deposition of platinum nanoparticles by using a chloroplatinic acid hexahydrate solution and depending on a time current method, and poly (3, 4-ethylenedioxythiophene) is generated by direct electro-polymerization on the surface of the Pt-modified microneedle electrode through an electrochemical constant current method. And forming uniform PEDOT (poly (3, 4-ethylenedioxythiophene)) film coated and modified platinum nanoparticles on the microneedle electrode. The composite modified carbon-based material is used for replacing precious metal to reduce cost and improve biocompatibility, low-oxygen sensitivity is optimized by means of composite modification, in-vivo protein adsorption and biological membrane coverage are resisted through anti-pollution surface modification, and therefore the defects are overcome, and monitoring of in-vivo tissue oxygen partial pressure is achieved.

The invention relates to the technical field of medical monitoring, in particular to a multi-source data integration grading early warning method and system for hand surgery vascular crisis. The invention discloses a multi-source data integration grading early warning method for hand surgery vascular crisis. The method comprises the following steps: S1, synchronously collecting tissue oxygen saturation, an original and uninjured side temperature difference value, behavioral environment data and clinical auxiliary data of a sentinel area through a multi-source sensor; s2, establishing a behavior recognition algorithm model, recognizing interference behaviors of the patient in real time based on the collected behavior environment data, and quantifying the interference behaviors to obtain influence data; and S3, based on the influence data, carrying out dynamic correction on the original and uninjured side temperature difference value to obtain a corrected and uninjured side temperature difference value, and carrying out dynamic correction on the tissue oxygen saturation to obtain the corrected tissue oxygen saturation. Through multi-source data fusion and intelligent correction, interference of patient behaviors and environmental factors on monitoring data can be effectively recognized and filtered out.

The application discloses a kind of local tissue oxygen saturation detection systems for postoperative free flap, including front-end flexible detection module and rear-end signal processing module;Front-end flexible detection module includes the flexible packaging layer of flexible material and the interface layer of being arranged on packaging layer, the material of interface layer is hydrogel mixture, and the detection circuit for being encapsulated in packaging layer is used to detect the blood oxygen saturation of human tissue;Rear-end signal processing module is connected with the front-end flexible detection module, and the rear-end signal processing module processes the signal detected by the front-end flexible detection module, and the local tissue oxygen saturation information is obtained by calculating detection signal.This application is all designed with flexibility, avoids the mechanical damage of detection part to measurement site, so that the sensing part can better adhere to the surface of human skin, improve the accuracy of measurement and the comfort of patient.

This invention relates to the field of medical device technology and discloses an intestinal mucosal tissue oxygen saturation monitoring device, comprising a monitor body, a catheter, a balloon, a near-infrared spectral emission and detection device, a lead wire, an inflation tube, an inflation device, a partition, and tubing one and tubing two. This invention can be used to directly, objectively, and continuously assess changes in small intestinal mucosal microcirculation and tissue oxygen consumption, and can be applied in various clinical environments. Furthermore, it is based on jejunal catheter placement technology, a mature and technically simple technique that can be performed bedside and is suitable for use in primary hospitals and general wards.

The invention provides a skin soft tissue pressure injury early warning system for orthopedic trauma nursing, and relates to the technical field of orthopedic nursing. A sensing monitoring module is arranged to monitor the temperature of the contact surface of an orthopedic fixing device and skin and the tissue oxygen saturation degree at the same time; the control processing module carries out trend analysis on the temperature and the tissue oxygen saturation, the control processing module generates a pressure reduction control instruction according to a trend analysis result or a pain trigger signal sent by the pain feedback module, and the inflation pressure reduction module controls the micro air bags at the corresponding positions to execute fixed-point deflation pressure reduction. Passive monitoring and passive adjustment are achieved through the sensing monitoring module, the control processing module and the inflation pressure reduction module, and active feedback and pressure reduction adjustment are achieved through the pain feedback module, the control processing module and the inflation pressure reduction module.

The invention provides an imaging method and system, a storage medium and computing device.The method comprises the steps that an oxygen-sensitive film which is prepared in advance and provided with an oxygen-sensitive probe is installed on to-be-detected tissue of a to-be-detected object; the to-be-detected tissue contains specific tissue cells sensitive to calcium signals; alternately irradiating the multiple types of exciting light on the to-be-detected tissue according to a target interval through the imaging path; according to the target interval, different cameras are used for continuously collecting all frames of first exciting light signals on the oxygen sensitive film, all frames of second exciting light signals of the specific tissue cells and all frames of reflected light signals of blood oxygen in the tissue to be detected; generating a tissue oxygen partial pressure image of the to-be-detected tissue according to the continuously collected frames of first excitation light signals, generating a calcium signal image of the to-be-detected tissue according to the continuously collected frames of second excitation light signals, and generating a blood oxygen signal image of the to-be-detected tissue according to the continuously collected frames of reflected light signals.

A circulatory device for maintenance of tissue oxygen levels in a subject includes a first conduit for fluid to flow into the device, a second conduit for fluid to flow out of the device. an oxygenator device, an oxygenator control unit, at least one fluid flow sensor, a flow control unit which provides input to the flow control element, and a flow control element configured to accept a variable input to modify the rate of fluid flow into and out of the device, and at least one tissue oxygen sensor. The device is affixed removably to the body of an individual.

The utility model provides a kind of tissue oxygen saturation micro monitoring probe, the utility model relates to severed finger replantation blood supply monitoring technical field, tissue oxygen saturation micro monitoring probe, comprising: probe body, two groups of optical fiber components are built-in in probe body, optical fiber component is used for light out and light in, and two pieces of astigmatism lens one and two pieces of condenser lens one are sealedly installed on the surface of probe body by opening, and astigmatism lens one and condenser lens one are respectively corresponding with the light outlet end, light inlet end of optical fiber component;Connecting wire, chip is built-in in connecting wire;The utility model has the beneficial effect that: it solves the existing probe due to wrapping sheet larger and influence postoperative observation;Emitting part and photoelectric detection device are burned after energization due to continuous light emission and heat and cause skin burn;And as well as the problem of high cost of probe use.

The invention relates to the field of biological medicine, and discloses application of urine-derived stem cells in ED treatment. According to the scheme, a 9-copy hypoxia response element, a minimum promoter, a vascular endothelial growth factor and a nerve growth factor gene are introduced into urine-derived stem cells by utilizing a lentiviral vector, and a hypoxia response type gene modified cell system is constructed. Through local injection of the cavernous body, the cells accurately start factor expression in an anoxic microenvironment. According to the invention, deep coupling of vascular regeneration and neural restoration can be realized, expression can be automatically reduced along with rising of tissue oxygen content, excessive hyperplasia complications can be avoided, and closed-loop intelligent treatment of pathological induction-precise intervention can be realized.