65 results about "Tissue oxygen" patented technology

The present invention provides a hyperspectral imaging system which demonstrates changes in tissue oxygen delivery, extraction and saturation during shock and resuscitation including an imaging apparatus for performing real-time or near real-time assessment and monitoring of shock, including hemorrhagic, hypovolemic, cardiogenic, neurogenic, septic or burn shock. The information provided by the hyperspectral measurement can deliver physiologic measurements that support early detection of shock and also provide information about likely outcomes.

Provided is a durable tissue pH / pCO2 and / or tissue oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising one or more sensor chambers within a biocompatible, gas-permeable membrane containing together in a single chamber, or in separate chambers, respectively, a pH sensitive fluorophor from which pCO2 level(s) are calculated when the fluorophor is excited and the resulting fluorescence is measured and / or an oxygen sensitive phosphor solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue pH / pCO2 and / or tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue pH / pCO2 and / or tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe.

A respiratory monitoring apparatus that detects changes in physiological parameters relevant to respiration, including blood oxygen and blood volume, using near infrared spectroscopy. Methods for diagnosing respiratory-related events including hypoxia index, hypopnea, arousal, tissue oxygen debt, and respiratory muscle events or distinguishing central from obstructive sleep apnea are also disclosed.

Disclosed are methods and compositions for increasing tissue oxygen levels by administration of superoxygenated compositions of tissue surfaces. The methods are applicable to treatment of a wide variety of conditions including burns, bedsores, ulcers, necrosis and anaerobic infections.

Provided is a durable oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising a sensor chamber within a biocompatible, gas-permeable membrane containing an oxygen sensitive analyte solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe.

A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.

A method and apparatus for determining an index indicative of a subject's response to an oxygen desaturation condition is provided. The method includes the steps of: a) providing a NIRS tissue sensor, a pulse oximetry sensor, and a processor in communication with the NIRS tissue sensor and the pulse oximetry sensor; b) sensing the subject's tissue using the NIRS tissue sensor and producing first signals; c) sensing the subject's tissue using the pulse oximetry sensor and producing second signals; d) processing the first signals to determine a change in tissue oxygen saturation values, processing the second signals to determine a change in arterial oxygen saturation values; and e) determining the index indicative of the subject's response to the oxygen desaturation condition using the change in tissue oxygen saturation values and the change in arterial oxygen saturation values.

A device and a method for the screening of in-vivo tumors in a target tissue are provided. The device and method provide a local measure of a risk of tumor presence in the target tissue with high specificity. The local measure may be based upon a non-linear combination of local hemoglobin and tissue oxygen saturation and other tissue characteristics.

A method and apparatus for determining a venous oxygen saturation value (SvO2) of a subject is provided. The method includes the steps of: a) sensing a plurality of tissue regions on a subject using a NIRS oximeter adapted to determine a tissue oxygen saturation value (StO2) for each region, each region independent of the other regions and each region sensed using a NIRS oximeter sensor specific to that region, and determining a StO2 value for that region; b) assigning a coefficient to each region, each of which coefficients reflects a portion of the StO2 value for the region attributable to a composite venous blood return representative of the tissue regions measured; and c) determining a composite SvO2 value for the subject using the StO2 region values and the respective coefficients.

Devices and systems have a sensor probe configured to measure tissue oxygen saturation in the intestine or mesentery. The devices and systems can determine the oxygenation state of the entire thickness of the intestine or mesentery. Thus, embodiments of the invention can be applied in diagnosing intestinal ischemia in a patient, as well as in monitoring tissue oxygen saturation of the intestine or mesentery during or after a surgical procedure.

The present invention provides a hyperspectral imaging system which demonstrates changes in tissue oxygen delivery, extraction and saturation during shock and resuscitation including an imaging apparatus for performing real-time or near realtime assessment and monitoring of shock, including hemorrhagic, hypovolemic, cardiogenic, neurogenic, septic or burn shock. The information provided by the hyperspectral measurement can deliver physiologic measurements that support early detection of shock and also provide information about likely outcomes.

Physiologic sensors and methods of application are described. These sensors function by detecting recently discovered variations in the spectral optical density at two or more wavelengths of light diffused through the skin. These variations in spectral optical density have been found to consistently and uniquely relate to changes in the availability of oxygen in the skin tissue, relative to the skin tissue's current need for oxygen, which we have termed Physiology Index (PI). Current use of blood gas analysis and pulse oximetry provides physiologic insight only to blood oxygen content and cannot detect the status of energy conversion metabolism at the tissue level. By contrast, the PI signal uniquely portrays when the skin tissue is receiving ‘less than enough oxygen,’‘just the right amount of oxygen,’ or ‘more than enough oxygen’ to enable aerobic energy conversion metabolism. The PI sensor detects one pattern of photonic response to insufficient skin tissue oxygen, or tissue hypoxia, (producing negative PI values) and a directly opposite photonic response to excess tissue oxygen, or tissue hyperoxia, (producing positive PI values), with a neutral zone in between (centered at PI zero). Additionally, unique patterns of PI signal response have been observed relative to the level of physical exertion, typically with a secondary positive-going response trend in the PI values that appears to correspond with increasing fatigue. The PI sensor illuminates the skin with alternating pulses of selected wavelengths of red and infrared LED light, then detects the respective amount of light that has diffused through the skin to an aperture located a lateral distance from the light source aperture. Additional structural features include means of internally excluding light from directly traveling from the light emitters to the photodetector within the sensor. This physiology sensor and methods of use offer continuous, previously unavailable information relating to tissue-level energy conversion metabolism. Several alternative embodiments are described, including those that would be useful in medical care, athletics, and personal health maintenance applications.

The invention is an oxygen saturation of blood in partial tissue in the brain of a newborn baby under the stimulation of absorbing oxygen, and its characteristic: it takes three photoelectric receiving tubes placed on the same straight line and a light source containing two LEDs as sensor, based on that in the tissue oxygen metabolism, oxyhemoglobin and reduced hemoglobin have different optical spectrum properties, and according to the light absorbing and scattering laws in the tissue, calculating the oxygen saturation rSO2 of blood in partial tissue, and on the condition of short-time pure oxygen absorbing, able to detect and calculate the variation of oxygen saturation of blood in partial tissue of a newborn baby. The three photoelectric receiving tubes are arranged at regular intervals, and the two LEDs can emit red and near-infrared lights, respectively. The invention can sensitively detect the oxygen saturation of blood in partial tissue of a newborn bay or bay suffering from diseases and its variation course.

Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Tissues remaining below a certain hemoglobin oxygen saturation threshold (oxygen saturation index <1) for prolonged periods (>6 h) became increasingly dehydrated, eventually becoming visibly necrotic. Tissues above this threshold (oxygen saturation index >1), despite being significantly hypoxic relative to the pre-elevation saturation values, remained viable over the 72 h post-elevation monitoring period. The magnitude of the drop in tissue oxygen saturation, as observed immediately following surgery, correlated with the final clinical outcome of the flap tissue. These results indicate the potential of near infrared spectroscopy and imaging to monitor tissue oxygenation status and assess tissue viability following reconstructive surgery. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

A multispectral medical imaging device includes illumination devices arranged to illuminate target tissue. The illumination devices emit light of different near-infrared wavelength bands. The device further includes an objective lens, a near-infrared image sensor positioned to capture image frames reflected from the target tissue, and a visible-light image sensor positioned to capture image frames reflected from the target tissue. A processor is configured to modulate near-infrared light output of the plurality of illumination devices to illuminate the target tissue. The processor is further configured to determine reflectance intensities from the image frames captured by the near-infrared image sensor and to generate a dynamic tissue oxygen saturation map of the target tissue using the reflectance intensities. The device further includes an output device connected to the processor for displaying the dynamic tissue oxygen saturation map.

Devices and systems have a sensor probe configured to measure tissue oxygen saturation in the intestine or mesentery. The devices and systems can determine the oxygenation state of the entire thickness of the intestine or mesentery. Embodiments of the invention also include methods for inducing a temporary ischemic period in an intestine or mesentery tissue and analyzing changes in oxygen saturation of the tissue during the temporary ischemic period or during a recovery phase. The devices, systems, and methods can be applied in diagnosing intestinal ischemia in a patient, as well as in monitoring tissue oxygen saturation of the intestine or mesentery during or after a surgical procedure.

The invention discloses a load enzyme hydrogel composition with oxygen releasing function and hydrogel prepared from the hydrogel composition, the the hydrogel composition contains a component A and a component B, wherein the active components of the component A are glucose oxidase, a catalyst for catalyzing hydrogen peroxide to produce oxygen, and hydrophilic colloid; the active components of the component B are glucose and a cross linking agent. The preparation method of the hydrogel is even mixing of the component A and the component B. The load enzyme hydrogel composition adopts raw materials belonging to the food or medical materials with high biological safety and good biocompatibility; and before use, the two components are not contacted and stable in performance. The hydrogel prepared by mixing of the hydrogel composition can continuously supply oxygen, can increase the oxygen partial pressure at the wound, improves the wound tissue oxygen supply, improves the local tissue aerobic metabolism, is conducive to healing, enables the oxygen to reach to the wound through the body outer surface other than blood circulation, is a local oxygen supply technology and easy to carry, and has wide popularization and application prospect.

A procedure and machine promotes healing by causing muscle fasciculation and contraction relaxation cycles that effectively pump blood through the microcirculation, draining the venous beds and raising the tissue oxygen levels. A high phase charged system is electronically pulsed and adjusted to induce deep-layered muscle contractions, causing greatly increased flow rates of both blood and lymphatics, patency of vessels permitting, and forcing blood into the microcirculation of the treated tissue. The machine electrical waveform stimulates angiogenesis, facilitating new tissue growth and repair in the healing process and raises the metabolic rate in the treated tissues.

An oximeter probe includes a probe unit or a base unit and a probe tip where the probe tip has a number of sources and detectors that can be accessed individually or in differing combinations for measuring tissue oxygen saturation at different tissue depth in tissue. A processor of the oximeter probe controls a multiplexer that is coupled to the detectors for selectively collecting measurement information from the detectors via the multiplexer. The oximeter probe is user programmable via one or more input devices on the oximeter probe for selecting the particular sources and detectors to collect measurement information from by the processor.

The invention provides an ethoxyl starch 130 / 0.4 sodium chloride injection, in which, 20-80g of ethoxyl starch 130 / 0.4 and 5-13g of sodium chloride is include in per litre injection. The invention further provides the preparing method and application of the injection. The ethoxyl starch 130 / 0.4 in the raw material of the medicine in the invention is an improved product of 'heas' used clinically for treating and preventing hypovolemia, acute normovolemic hemodilution and so on. A better normovolemic therapeutic effect is achieved by optimizing molecular weight and molecular weight distribution, reducing displacement grade and changing displacement manner (C2 / C6); it can stays in blood for longer time after intravenous drip, consequently, can increase plasma osmotic pressure, tissue fluid back-flow and blood volume, can improve oxygenation condition in or after major operation evidently, and can increase tissue oxygen partial pressure and improve tissue oxygenation faster and earlier, thereby can satisfy the clinic demand better.

An oximeter probe that takes into account tissue color (e.g., skin color or melanin content) to improve accuracy when determining oxygen saturation of tissue. Light is transmitted from a light source into tissue having melanin (e.g., eumelanin or pheomelanin). Light reflected from the tissue is received by a detector. A compensation factor is determined to account for absorption due to the melanin. The oximeter uses this compensation factor and determines a melanin-corrected oxygen saturation value.

The invention discloses a fracture healing simulation method based on a tissue oxygen environment and a mechanical environment. The method comprises the steps of establishing a three-dimensional geometric model of a fracture part, meshing the obtained geometric model to establish a finite element model of a bone and a callus, analyzing and solving the finite element model to calculate a partial strain of a fracture area, establishing a vascular growth model of the fracture area according to force stimulation, establishing each cell proliferation and differentiation model of the fracture area,establishing an oxygen transport model of the fracture area, calculating a new material attribute in a tissue, establishing a fracture healing iteration simulation process of a force biological adjustment algorithm, and judging whether the material attribute in the tissue reaches a material attribute value of the bone or not according to the calculated tissue material attribute value, completing simulation if so, otherwise updating the tissue material attribute value and entering into next iteration simulation.

The invention discloses a nanometer far-infrared diatom ooze functional wall material, and belongs to the technical field of decoration function materials. The nanometer far-infrared diatom ooze functional wall material is prepared from, by mass, 30.0-40.0 parts of refining diatomite, 8.0-15.0 parts of nanometer far-infrared powder, 25.0-30.0 parts of gel material, 2.5-4.0 parts of dispersible adhesive powder, 2.0-4.0 parts of nanometer titanium dioxide, 4.0-30.0 parts of powder stuffing, 0.5-1.0 part of additive, 2.0-3.0 parts of wood fiber and 100-120 parts of water. The nanometer far-infrared diatom ooze functional wall material can maintain the existing performance of diatom ooze of being safe, environmentally friendly, strong in adsorption effect, adjusting air humidity, purifying formaldehyde and bringing convenience to construction, meanwhile play the function of far-infrared radiation, form a certain heat effect to a human body, improve tissue oxygen supply, promote angiectasis, promote blood circulation, enhance human body metabolism, promote discharge of waste in the human body, improve human body immunity, and accordingly achieve the health care effect for the human body.

The invention discloses a method for preparing a core-shell structure drug carrier with near-infrared light remote response and an application thereof, belongs to the field of biomedical materials, and particularly discloses a method for preparing a core-shell structure drug carrier with near-infrared light remote response and an application thereof. The invention aims at solving the problems of shallow light source penetration depth, high cost and big risk of the current atherosclerosis traditional photodynamics therapy. The method comprises the following steps: firstly synthesizing a core-shell structure nano-particle coated with a photosensitizer, wherein the nano-particle is swallowed by the cell in the cell co-culture process; and radiating the cell by near-infrared light, wherein under the stimulation of the near-infrared light, the nano-particle in the cell is acted with the tissue oxygen to generate a cytotoxic active oxygen molecule singlet oxygen (1O2) so as to kill the cell till apoptosis. The core-shell structure drug carrier with near-infrared light remote response prepared by the invention is taken as a medical carrier for inhibiting and killing the atherosclerosis plaque cell.

The invention discloses an integrating sphere model for calibrating tissue oxygen indexes. The integrating sphere model comprises a hemispherical integrating sphere, a base, a color filter and a barrier. The hemispherical integrating sphere is supported by the base, the color filter is convenient to replace, the barrier covers the upper side of the hemispherical integrating sphere, a light hole of a light source and three light holes of receivers are formed in the barrier and are arrayed to form a straight line, the color filter comprises a group of light-transmittance films which have unequal absorptive actions on photons at wavelengths of 760nm and 840nm and nonlinear absorption lines near the wavelengths of 760nm and 840nm, and the color filter is selectively placed on one light hole of the receiver. The integrating sphere model has the advantages that the stable optical integrating sphere model is used as a calibrating medium of a blood oxygen instrument instead of a blood model and is stable and reliable in performance; the color filter is used during calibration, so that the integrating sphere model can have different attenuation actions on the photons at the different wavelengths, tissue oxygen index values measured by the blood oxygen instrument can be calibrated in a multi-point manner, and a calibration effect can be improved.

An oximeter probe is user configurable for being in an absolute reporting mode and a relative reporting mode for measured values. The measured values for the absolute and relative modes include absolute oxygen saturation, relative oxygen saturation, absolute hemoglobin content, relative hemoglobin content, absolute blood volume, relative blood volume. The relative modes and absolute modes for determining and reporting relative or absolute hemoglobin content or relative or absolute blood volume for individual patients are beneficial when determining the efficacy of administered medications, such as epinephrine, that effect blood flow, but not oxygen saturation, in tissue, such as skin. The oximeter probe in these relative modes displays the efficacy of the administered medication as reported values for relative hemoglobin content or relative blood volume fall or rise.

The invention discloses a pure oxygen- photodynamic composite skin therapeutic instrument which comprises a main body, an irradiator and a spiral arm connected between the main body and the irradiator, wherein a light source circuit board is arranged on the irradiator, and a light-emitting element is fixedly arranged on the light source circuit board; and an oxygen spray nozzle unit is further arranged on the irradiator, an oxygen making device is arranged on the main body, and the oxygen spray nozzle unit is connected to the oxygen making device through a pipeline. The tissue oxygen concentration can be increased and the photodynamic therapeutic effect can be significantly improved by adopting a design of the oxygen making device and the oxygen spray nozzle unit; by adopting the design of a light wavelength feedback module and a light dose feedback module, the pure oxygen-photodynamic composite skin therapeutic instrument can ensure that an irradiated region can obtain the same light dose so that the photodynamic therapeutic effect can be improved; and as the light-emitting element is a composite light-emitting diode with three wavelengths, the single wavelength or the two wavelengths or the three wavelengths can be selected for performing combined therapy according to actual needs.