Fracture healing simulation method based on tissue oxygen environment and mechanical environment

A mechanical environment and fracture healing technology, applied in the field of biomedical engineering, can solve problems such as inability to achieve fixator optimization, fixator selection restrictions, and hindering treatment plans

Inactive Publication Date: 2018-01-19
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) The important influence of the oxygen environment on the proliferation and differentiation of cells in the tissue during the fracture healing process is not considered
[0005] (2) The current model cannot simulate different types of fracture healing in different p

Method used

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  • Fracture healing simulation method based on tissue oxygen environment and mechanical environment
  • Fracture healing simulation method based on tissue oxygen environment and mechanical environment
  • Fracture healing simulation method based on tissue oxygen environment and mechanical environment

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0059] Specific implementation mode one: establish a three-dimensional geometric model of the fracture site;

[0060] The establishment process of the 3D geometric model of the fracture site is as follows:

[0061] (1) Multiple images in DICOM format obtained from medical imaging CT scans,

[0062] (2) Then import it into Mimics software for 3D reconstruction,

[0063] (3) Import the 3D reconstructed model into Geomagic software for smoothing and materialization operations to obtain a 3D geometric model of the fracture site;

specific Embodiment approach 2

[0064] Specific embodiment two: import the obtained geometric model into Hypermesh for grid division, and set up the finite element model of linear elastic bone and callus;

specific Embodiment approach 3

[0065] Specific embodiment three: assign a value to the material attribute at the initial moment in the callus, and assign the material attribute at the initial moment in the callus to the material attribute value of the granulation tissue;

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Abstract

The invention discloses a fracture healing simulation method based on a tissue oxygen environment and a mechanical environment. The method comprises the steps of establishing a three-dimensional geometric model of a fracture part, meshing the obtained geometric model to establish a finite element model of a bone and a callus, analyzing and solving the finite element model to calculate a partial strain of a fracture area, establishing a vascular growth model of the fracture area according to force stimulation, establishing each cell proliferation and differentiation model of the fracture area,establishing an oxygen transport model of the fracture area, calculating a new material attribute in a tissue, establishing a fracture healing iteration simulation process of a force biological adjustment algorithm, and judging whether the material attribute in the tissue reaches a material attribute value of the bone or not according to the calculated tissue material attribute value, completing simulation if so, otherwise updating the tissue material attribute value and entering into next iteration simulation.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a fracture healing simulation method based on tissue oxygen environment and mechanical environment. Background technique [0002] With the development of transportation, construction and other industries and the intensification of population aging, the number of patients with traffic injuries, construction injuries and elderly osteoporotic fractures has increased rapidly. According to the statistics of traffic accidents in 2015, a total of 10,597,358 car accidents occurred in 2015, 98.5% of whom were injured; according to the big data on the health of the elderly in China in 2015, osteoporosis has leapt to the No. 1 common disease and frequently-occurring disease. seven. The prevalence rate of people over 60 years old is 56%, and the incidence rate of women is 60%-70%. Among them, the incidence of fracture is close to one-third, and the annual medical expenses need RMB 15 ...

Claims

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Application Information

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IPC IPC(8): G16H50/50
Inventor 王沫楠王新宇杨宁
Owner HARBIN UNIV OF SCI & TECH
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