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Hydroxyethyl starch 130/0.4 sodium chloride injection and preparation method and use thereof

A technology of sodium chloride injection and hydroxyethyl starch, which can be applied in the directions of alkaline/alkaline earth metal chloride active ingredients, blood diseases, pharmaceutical formulations, etc., and can solve problems such as inability to meet clinical needs.

Inactive Publication Date: 2009-06-10
CHENGDU ZHENGKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But a single hydroxyethyl starch 200 / 0.5 preparation can not meet the clinical needs

Method used

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  • Hydroxyethyl starch 130/0.4 sodium chloride injection and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of the injection of the present invention

[0020] 1. The composition of the prescription

[0021] Hydroxyethyl starch 130 / 0.4 60g

[0022] Sodium chloride added to 9g

[0023] 0.1mol / L hydrochloric acid appropriate amount

[0024] Add water for injection to 1000ml

[0025] Each bottle contains hydroxyethyl starch 130 / 0.4 30g and sodium chloride 4.5g

[0026] 2. Production process

[0027] Pre-treatment: Treat the infusion bottle, butyl rubber stopper and aluminum cap as required for injection.

[0028] Concentrated preparation: Weigh the hydroxyethyl starch 130 / 0.4 and sodium chloride of the recipe, add them into the batching tank, and under stirring, use water for injection newly prepared by 50% of the total volume to completely dissolve them.

[0029] Activated carbon adsorption: Add 0.1% (g / ml) of activated carbon for needles, boil for 20 minutes, decarbonize with a medium-speed sand filter rod, add water for injection to the full amount,...

Embodiment 2

[0036] Example 2 Preparation of the injection of the present invention

[0037] Hydroxyethyl starch 130 / 0.4 20g

[0038] Sodium chloride added to 5g

[0039] Prepare according to the method of Example 1.

Embodiment 3

[0040] Example 3 Preparation of the injection of the present invention

[0041] Hydroxyethyl starch 130 / 0.4 80g

[0042] Sodium chloride added to 13g

[0043] Prepare according to the method of Example 1.

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Abstract

The invention provides an ethoxyl starch 130 / 0.4 sodium chloride injection, in which, 20-80g of ethoxyl starch 130 / 0.4 and 5-13g of sodium chloride is include in per litre injection. The invention further provides the preparing method and application of the injection. The ethoxyl starch 130 / 0.4 in the raw material of the medicine in the invention is an improved product of 'heas' used clinically for treating and preventing hypovolemia, acute normovolemic hemodilution and so on. A better normovolemic therapeutic effect is achieved by optimizing molecular weight and molecular weight distribution, reducing displacement grade and changing displacement manner (C2 / C6); it can stays in blood for longer time after intravenous drip, consequently, can increase plasma osmotic pressure, tissue fluid back-flow and blood volume, can improve oxygenation condition in or after major operation evidently, and can increase tissue oxygen partial pressure and improve tissue oxygenation faster and earlier, thereby can satisfy the clinic demand better.

Description

technical field [0001] Hydroxyethyl starch 130 / 0.4 sodium chloride injection belongs to the field of medicine. Background technique [0002] As a blood volume expansion drug, artificial colloid plays an extremely important role in the treatment and prevention of hypovolemia and shock. Compared with plasma, albumin and crystalloid, artificial colloids have the advantages of low cost and long action time as blood volume expansion drugs, and can effectively avoid the occurrence of infectious diseases caused by the use of blood products. The hydroxyethyl starch solution using corn starch as raw material is the third generation of artificial colloids after gelatin and dextran colloids. A popular plasma volume expander with broad market prospects. [0003] At present, the commonly used hydroxyethyl starch in the Chinese market is 200 / 0.5 hydroxyethyl starch, which is a medium molecular weight hydroxyethyl starch. And successively listed in some countries, especially in Europe t...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P7/00A61K31/718
Inventor 朱贞华
Owner CHENGDU ZHENGKANG PHARMA
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