Novel controlled release capsule and preparation method thereof

A capsule and capsule technology, applied in the field of medicine, can solve the problems of being unsuitable for the preparation of osmotic pump tablets, many restrictive factors of drugs, complicated preparation process, etc., and achieve the effects of fast onset of drug effect, simplified selection of excipients, and simple preparation process.

Inactive Publication Date: 2009-07-22
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Conventional osmotic pump controlled-release preparations (no matter single-chamber or multi-chamber osmotic pump tablets) have the disadvantages of high equipment requirements, complicated preparation process, and many drug limiting factors.
The preparation of the tablet core is a complex process. Due to the complex process of the tablet, certain binders, disintegrants, lubricants and other auxiliary materials must be added to the prescription of the tablet, while the preparation process of the capsule is simple. Osmotic pump tablets are generally suitable for drugs with small doses and moderate solubility (50-300g·L-1 water) due to the limitation of tablet volume and drug solubility. Drugs with large doses and too high or too low solubility are not suitable. Osmotic pump tablets

Method used

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  • Novel controlled release capsule and preparation method thereof
  • Novel controlled release capsule and preparation method thereof
  • Novel controlled release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Controlled release capsule capsule body composition:

[0030]

[0031] Preparation process: Preparation of controlled-release capsule capsules: first dissolve cellulose acetate in a solvent of acetone: absolute ethanol = 4:1, add polyethylene glycol-400 and polyethylene glycol-2000 as plasticizers and The porogen is made by dipping in glue, dried, and a drug release hole with a diameter of 1.0mm is prepared on the capsule by mechanical drilling, sealed with gelatin solution and dried, pulled out, cut, and sorted to obtain controlled release. The cap and body of the capsule body.

[0032] Taking paracetamol as the model drug, 30mg of paracetamol raw material is filled into the capsule cap of ordinary capsules in powder form; another 70mg of paracetamol raw material and 35mg of sodium chloride are mixed, and filled into the controlled-release capsule body in powder form, and the controlled-release capsule The body is sealed with the same glue as the capsule material; ...

Embodiment 2

[0035] Controlled release capsule capsule body composition:

[0036]

[0037] Preparation process: Preparation of controlled-release capsules: first dissolve cellulose acetate in acetone, add polyethylene glycol-200, PVP-K30, and polyethylene glycol-4000 as plasticizers and porogens, and the preparation process Same as Example 1, prepare a drug release hole with a diameter of 0.8mm on the capsule body by mechanical drilling method, seal the gelatin solution and dry, pull out the shell, cut, arrange, and obtain the capsule shell of the osmotic pump.

[0038] Taking paracetamol as the model drug, 30mg of paracetamol raw material is filled into the capsule cap of ordinary capsules in powder form; in addition, 70mg of paracetamol raw material and 70mg of sucrose are mixed, and filled into the controlled-release capsule body in powder form, which is used for the controlled-release capsule body Seal with the same glue as the capsule material; then nest the capsule cap of the ordi...

Embodiment 3

[0040] Controlled release capsule capsule body composition:

[0041]

[0042] Preparation process: Preparation of controlled-release capsules: first dissolve ethyl cellulose in 95% ethanol, add polyethylene glycol-400 and sodium carboxymethyl cellulose as plasticizers and porogens, add titanium dioxide and stir Evenly, the preparation process is the same as in Example 1. A drug release hole with a diameter of 1.0 mm is prepared on the capsule body with a mechanical punching method, and the gelatin solution is sealed.

[0043] Taking sagrelate hydrochloride as the model drug, 30mg of sargrelate hydrochloride raw material is filled into the capsule cap of ordinary capsules in powder form; another 70mg of sarcogrelate hydrochloride raw material and 60mg of lactose are mixed, and filled into controlled-release capsules in powder form In the body, the capsule body of the controlled-release capsule is sealed with the same glue as the capsule material; then the capsule cap of the ...

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Abstract

The invention relates to a novel controlled-release capsule and a method for preparing the same. The capsule has the advantages of simultaneously having a quick release part and a controlled-release part, along with simple preparation process and wide drug selection range. The novel controlled-release capsule consists of a capsule cap and a controlled-release capsule body, wherein the capsule cap is a common capsule shell sold in markets, the controlled-release capsule body is an osmotic pump controlled-release capsule which can be used to encapsulate chemicals, traditional Chinese medicines, biological product medicines and the like, and the medicines are packaged in the capsule cap and the controlled-release capsule body respectively. Tests show that the capsule preparation can quickly release the medicines, and the release rate of the remained medicines is constant.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a novel controlled-release capsule with quick release and a preparation method thereof. The controlled-release preparation of the invention can be used for chemical medicines, traditional Chinese medicines, biological products medicines, nutritional substances and the like. The medicines first release an initial dose, and the rest of the medicines release at a constant rate. Background technique [0002] The research and development of sustained / controlled release preparations has become a hot spot in the research and development of medicine in the world today. Sustained / controlled release preparations can slowly release drugs within a predetermined period as required, provide the human body with an appropriate blood drug concentration, reduce the number of doses and obtain good therapeutic effects. Among them, the drug release of controlled-release preparations is more stable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/56
Inventor 傅红兴徐艳艳万常伟赵应征孙晓杰钱水水杨栋李剑波厉星王艺杨伟
Owner WENZHOU MEDICAL UNIV
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