44 results about "Reduced hemoglobin" patented technology

A system for determining a biologic constituent including hematocrit transcutaneously, noninvasively and continuously. A finger clip assembly includes including at least a pair of emitters and a photodiode in appropriate alignment to enable operation in either a transmissive mode or a reflectance mode. At least one predetermined wavelength of light is passed onto or through body tissues such as a finger, earlobe, or scalp, etc. and attenuation of light at that wavelength is detected. Likewise, the change in blood flow is determined by various techniques including optical, pressure, piezo and strain gage methods. Mathematical manipulation of the detected values compensates for the effects of body tissue and fluid and determines the hematocrit value. If an additional wavelength of light is used which attenuates light substantially differently by oxyhemoglobin and reduced hemoglobin, then the blood oxygen saturation value, independent of hematocrit may be determined. Further, if an additional wavelength of light is used which greatly attenuates light due to bilirubin (440 nm) or glucose (1060 nm), then the bilirubin or glucose value may also be determined. Also how to determine the hematocrit with a two step DC analysis technique is provided. Then a pulse wave is not required, so this method may be utilized in states of low blood pressure or low blood flow.

A system for determining a biologic constituent including hematocrit transcutaneously, noninvasively and continuously. A finger clip assembly includes including at least a pair of emitters and a photodiode in appropriate alignment to enable operation in either a transmissive mode or a reflectance mode. At least one predetermined wavelength of light is passed onto or through body tissues such as a finger, earlobe, or scalp, etc. and attenuation of light at that wavelength is detected. Likewise, the change in blood flow is determined by various techniques including optical, pressure, piezo and strain gage methods. Mathematical manipulation of the detected values compensates for the effects of body tissue and fluid and determines the hematocrit value. If an additional wavelength of light is used which attenuates light substantially differently by oxyhemoglobin and reduced hemoglobin, then the blood oxygen saturation value, independent of hematocrit may be determined. Further, if an additional wavelength of light is used which greatly attenuates light due to bilirubin (440 nm) or glucose (1060 nm), then the bilirubin or glucose value may also be determined. Also how to determine the hematocrit with a two step DC analysis technique is provided. Then a pulse wave is not required, so this method may be utilized in states of low blood pressure or low blood flow.

The invention discloses a biological tissue blood flow, blood oxygen and blood volume multi-parameter detection method and device. According to the method, two laser beams, differing in wavelength, simultaneously irradiate a biological tissue; and multiple frames of biological tissue colored images, which are illuminated by the laser beams, are continuously acquired by a photoelectric imaging system. The light intensity values of a red channel and a green channel on each pixel of the images are obtained for respectively constituting a red channel image and a green channel image. By virtue of a laser speckle blood flow imaging data analysis method and a dual-wavelength spectroscopic data analysis method, the red channel image and the green channel image are processed, so that two-dimensional spatial distribution and dynamic variation information thereof of a plurality of physiological parameters including blood flow, oxyhemoglobin concentration and reduced hemoglobin concentration of the corresponding biological tissue are obtained. The method and the device disclosed by the invention solve the shortcoming that a multi-wavelength time-sharing imaging based multi-parameter blood flow imaging system has difficulty in achieving the synchronization of accurate time and also avoid the shortcoming that a multi-camera shooting based multi-parameter blood flow imaging system is high in cost due to the use of a plurality of cameras.

A mastication monitoring device 1 is provided with a probe 2 which is attached to a cheek in order to detect the concentration of reduced hemoglobin in the masticatory muscles. A photodetector 22 of the probe 2 detects light scattered in the masticatory muscles and delivers a signal of the amount of light received to a signal processing unit 3. The signal processing unit 3 computes the reduced hemoglobin concentrations (time-series changes) from the signals of the amount of light received, and further computes outputs S (time-series changes) corresponding to the time-series changes in the reduced hemoglobin concentrations. A mastication iteration counting unit 41 detects peaks in periodical changes of Sd which is the difference between the output S and the moving average value Sma of the output S and counts the peaks in periodical changes of Sd as the mastication iterations.

A method for measuring the absolute concentration of oxygenated and reduced hemoglobin in human tissue features that its sensor is composed of 2 photoelectric receiving tubes and at least 3 light sources with different wavelengths, which are arranged on a straight line at intervals. Said absolute concentration can be calculated out. Said light source can emit respectively red light and near infrared light.

The invention is a near-infrared nondestructive tissue detecting method for skeletal muscle supersession function's blood transporting parameters, its character: in view of different tested objects (sportsman and non sportsman) and muscle tissue's oxyhemoglobin variation (deta HbO2) as well as reduced hemoglobin variation (deta Hb), it selects proper detecting distance and gives the detecting steps, algorithm and system design which can judge parameters of oxygen supersession ability of muscle tissue. The sensor can be composed of three LEDs and a photoelectric receiver. The whole testing system contains sensor, preamplifying circuit, A / D converter, inserted microprocessor, power supply, liquid crystal and touch screen. It has the advantages of high detecting sensitivity and simple detecting system structure.

A near-infrared brain-machine interface signal detection method integrating independent component analysis and least square method belongs to the technical field of hemoglobin concentration detection, and solves the problems that oxyhemoglobin concentration change and reduced hemoglobin concentration variation obtained via detection are not exact in the near-infrared brain-machine interface detection due to human physiological interference, thereby influencing the accurate extraction of brain function activity signal. Through the signal detection method, diffuse reflection light intensities are recorded when the brain is in resting state and in induced motivation with a detector, so as to obtain time sequences of Delta OD<N> Lambda 1(k) and Delta OD<N> Lambda 2(k), Delta OD<F> Lambda 1(k) and Delta OD<F> Lambda 2(k); then the Delta [HbO2]<N> (k), Delta [HHb]<N> (k), Delta [HbO2]<F> (k) and Delta [HHb]<F> (k) are obtained; the x1(k) is used for representing the Delta [HbO2]<N> (k) or the Delta [HHb2]<N> (k) in the step 2; the x2(k) is used for representing the Delta [HbO2]<F> (k) or Delta [HHb]<F> (k) in the step 2; the brain function signal expression s(k) is calculated; and the brain function signal s(k) is solved. The near-infrared brain-machine interface signal detection method is suitable for signal detection of brain-machine interface.

The present invention relates to a system for measuring the hemoglobin concentration in whole blood, wherein the system comprises: a light-radiating unit including a light source that emits two types of incident light having different wavelengths; a diffusion unit which diffuses the incident light emitted by the light-radiating unit; a cuvette-holding unit which is formed so as to hold a cuvette including a blood sample; a detection unit which detects each absorbance of the two types of incident light having different wavelengths; a processing unit which determines the hemoglobin concentration in the blood by processing the measured absorbance result; and a control unit which regulates the two types of incident light having different wavelengths in order to repeatedly / sequentially radiate same. Although the system for measuring hemoglobin in whole blood of the present invention uses a small amount of whole blood, it is possible to measure the total hemoglobin concentration in an accurate and reliable manner. The system of the present invention aligns the paths of two types of incident light having different wavelengths passing through a microcuvette by using a diffuser plate so as to easily align a light source and increase the reliability of the results. Also, the system of the present invention uses two wavelengths so as to rapidly and accurately measure the total amount of hemoglobin, including oxidized and reduced hemoglobin.

The invention is an oxygen saturation of blood in partial tissue in the brain of a newborn baby under the stimulation of absorbing oxygen, and its characteristic: it takes three photoelectric receiving tubes placed on the same straight line and a light source containing two LEDs as sensor, based on that in the tissue oxygen metabolism, oxyhemoglobin and reduced hemoglobin have different optical spectrum properties, and according to the light absorbing and scattering laws in the tissue, calculating the oxygen saturation rSO2 of blood in partial tissue, and on the condition of short-time pure oxygen absorbing, able to detect and calculate the variation of oxygen saturation of blood in partial tissue of a newborn baby. The three photoelectric receiving tubes are arranged at regular intervals, and the two LEDs can emit red and near-infrared lights, respectively. The invention can sensitively detect the oxygen saturation of blood in partial tissue of a newborn bay or bay suffering from diseases and its variation course.

The invention provides an endoscope system and a motion control method thereof, and a processor device; therefore, even if the difference of oxygen states of blood vessels is very small, the difference can be identified to be color difference being displayed; a test body is illuminated by narrow band light of a first different absorb waveband with oxyhemoglobin having a bigger light absorption factor than reduced hemoglobin having a smaller light absorption factor, and the test body is videoed to obtain blue image data Bx. The test body, illuminated by G light having green waveband, is videoed to obtain green image data Gy; intensity ratio B / G is calculated according to the blue image data Bx and the green image data Gy; the intensity ratio B / G and the reduction of the oxygen saturation correspondingly enlarges; gain processing corresponding to the intensity ratio B / G is carried out for the blue image data Bx and the green image data Gy, thereby obtaining blue image data Bx* and green image data Gy*. And oxygen saturation image can be displayed according to the blue image data Bx* and green image data Gy*.

The invention mainly relates to an LED-based noninvasive blood oxygen saturation tester. A blood oxygen probe is arranged on a portion to be measured, after red light and infrared light are emitted from a light emitting source and transmit through a human body, a received light signal is converted into a micro-current signal by a photoelectric detector, the micro-current signal is acquired and then converted into a voltage signal, and then the voltage signal is amplified and filtered. The amplified voltage signal is a pulse signal, and related information of blood oxygen saturation is carried by waveform of the pulse signal. The amplified voltage signal is acquired by a data acquisition card and sent into a PC (personal computer) to be subjected to an algorithmic process. Due to the fact that reduced hemoglobin and oxyhemoglobin in blood have special absorption spectrum in red light and infrared light zones, blood components in tissues can be researched, and information of the blood oxygen saturation can be detected. The LED-based noninvasive blood oxygen saturation tester can measure human internal blood oxygen saturation continuously in real time, cannot hurt the human body, and has the advantages of simple structure, flexibility in use, safety and reliable results.

The invention discloses a non-invasive measurement of hemoglobin concentration based on principle of optical reflection. The method comprises the following steps: arranging a light source and a photoelectric detector; determining the relationship between absorbance and the concentrations of oxyhemoglobin and reduced hemoglobin in deep tissue; a light source emitting near-infrared incident light with wavelength lambda 1 and lambda 2, a first photodetector and a third photodetector respectively acquiring the absorbance reflected by human skin tissue; the light source emitting near-infrared incident light with wavelength lambda 1 and lambda 2, and a second photodetector and the fourth photodetector respectively acquiring the absorbance reflected by human skin tissue; by introducing the correction coefficients [omega](i) 1 and [omega] (i) 2, the concentrations of oxyhemoglobin and reduced hemoglobin in deep tissues were obtained respectively. The concentration of hemoglobin tHb in deep tissues was obtained by adding the two concentrations together. The invention realizes non-invasive measurement of hemoglobin concentration, has low measurement cost and high measurement accuracy.

The invention relates to a near-infrared brain function signal processing method, in particular to a near-infrared brain function signal processing method based on differential pathlength factor estimation. The invention is intended to solve the problem of the prior art that since a big difference exists between a differential pathlength factor reference value used in modified Lambert-Beer's law and a real differential pathlength factor of an actual measurement object and measurement error disturbances also occur in time series signals of light intensity variation acquired by a light source detector, measurement and extraction of continuous wave near-infrared brain functional activity response signals are low in precision. The method of the invention includes: acquiring a time signal of light intensity variation under the fact that near-infrared rays of different wavelengths have an equal distance away from the detector; using modified Lambert-Beer's law to construct equations for thesignal; modifying the equations in matrix form; subjecting an augmented matrix to singular value decomposition so as to obtain a total least squares solution to concentration variation time signals ofoxyhemoglobin and reduced hemoglobin at the detector. The method of the invention is applicable to the field of brain function signals.

In the special observation mode, second illumination light including different-absorption-wavelength light that has different absorption coefficients for oxygenated hemoglobin and reduced hemoglobin is emitted, a turn-off state is thereafter initiated, and signal reading is performed for some of a plurality of pixel rows in accordance with a skip read method. Subsequently, first illumination light, which is normal light, is emitted, a turn-off state is thereafter initiated, and signal reading is performed for all of the pixel rows in a column direction in accordance with a pixel addition read method. An image processor generates an oxygen saturation image on the basis of a second image capture signal read in accordance with the skip read method and a first image capture signal read in accordance with the pixel addition read method, and generates a normal observation image on the basis of the first image capture signal.

The invention discloses a health bracelet. The bracelet comprises a blood oxygen signal conditioning module and an electrocardio detection module, wherein the blood oxygen signal conditioning module is used for conducting preamplification and signal separation on blood oxygen data, performing phase sensitive detection on an electrical signal of reduced hemoglobin and low-pass filtering on an electrical signal of oxyhemoglobin respectively, extracting useful information of the above two signals completely, inputting the two processed electrical signals into a controller module, combining the data of a three-axis acceleration detecting module to calculate the oxygen saturation, and avoiding the emergence of artifact; the accuracy of the oxygen saturation data is improved through the disposition of the blood oxygen signal conditioning module; the electrocardio detection module is used for conducting one-stage amplification, trapped wave processing, low-pass filtering and two-stage amplification on detected electrocardio data, an electrocardio signal is amplified, the bioelectrical signal frequency is filtered out so as to remove unexpected interference based on the characteristic frequency of a power frequency signal and an myoelectric signal, artifact is removed, and the effectiveness of the electrocardio signal is improved, so is the accuracy of the eletrocardio data. The improvement of the accuracy of the blood oxygen and electrocardio basic data is beneficial to improving the detection accuracy of the health bracelet.

The invention is a near-infrared nondestructive tissue detecting method for skeletal muscle supersession function's blood transporting parameters, its character: in view of different tested objects (sportsman and non sportsman) and muscle tissue's oxyhemoglobin variation (deta HbO2) as well as reduced hemoglobin variation (deta Hb), it selects proper detecting distance and gives the detecting steps, algorithm and system design which can judge parameters of oxygen supersession ability of muscle tissue. The sensor can be composed of three LEDs and a photoelectric receiver. The whole testing system contains sensor, preamplifying circuit, A / D converter, inserted microprocessor, power supply, liquid crystal and touch screen. It has the advantages of high detecting sensitivity and simple detecting system structure.

The invention discloses a blood-gas analyzer and a detection method thereof. The blood-gas analyzer comprises a blood sample introduction device, a reagent blank introduction device, a cleaning reagent introduction device, a waste liquid recovery device, an electrochemical detection device, an optical detection device, a three-way rotary valve and a double-way rotary valve. Through the three-way rotary valve and the double-way rotary valve, electrochemical detection and optical detection are skillfully combined. A whole blood sample to be detected is subjected to pH and ion determination and simultaneously, the optical detection method determines oxidized hemoglobin and reduced hemoglobin. The blood-gas analyzer saves time, simplifies operation and reduces a patient seek treatment cost. The apparatus detection process is completely automatic so that the detection is convenient and fast and human influence is small.

The invention is an oxygen saturation of blood in partial tissue in the brain of a newborn baby under the stimulation of absorbing oxygen, and its characteristic: it takes three photoelectric receiving tubes placed on the same straight line and a light source containing two LEDs as sensor, based on that in the tissue oxygen metabolism, oxyhemoglobin and reduced hemoglobin have different optical spectrum properties, and according to the light absorbing and scattering laws in the tissue, calculating the oxygen saturation rSO2 of blood in partial tissue, and on the condition of short-time pure oxygen absorbing, able to detect and calculate the variation of oxygen saturation of blood in partial tissue of a newborn baby. The three photoelectric receiving tubes are arranged at regular intervals, and the two LEDs can emit red and near-infrared lights, respectively. The invention can sensitively detect the oxygen saturation of blood in partial tissue of a newborn bay or bay suffering from diseases and its variation course.

An in vivo monitoring method in a laparoscope system is provided. An object image is sequentially created with expression of a surface color of an object in a body cavity. A lock area (specific area) is determined within the object image, the lock area being movable by following motion of the object. A monitor image including a graph of oxygen saturation is generated according to a part image included in the object image and located in the lock area. The monitor image is displayed. Preferably, the oxygen saturation of the lock area is acquired according to two spectral data with respect to wavelengths of which an absorption coefficient is different between oxidized hemoglobin and reduced hemoglobin in data of the object image. The object is constituted by a blood vessel.

The invention relates to the technical field of medical instruments, and discloses a respiratory interruption monitoring instrument. The respiratory interruption monitoring instrument comprises a controller, a finger blood oxygen clamp, a transmission line and a display screen, wherein the left end of the controller is fixedly connected with the right end of the transmission line, the right end ofthe finger blood oxygen clamp is fixedly connected with the left end of the transmission line, an upper clamping plate internally comprises an upper valve groove, a first soft layer, an infrared light LED lamp, a first induction lamp, an upper fixing column, an upper fixing base, a transmission line interface and a button. When the respiratory interruption monitoring instrument is used, a fingerof a to-be-monitored person is clamped by the finger blood oxygen clamp, the controller and the button are started, and data is transmitted to the display screen arranged on the controller through thetransmission line to be displayed in a curve form; a blue line indicates a reduced hemoglobin induction curve of a receiving tube when the hemoglobin does not carry oxygen molecules; a red line indicates hemoglobin and an oxyhemoglobin induction curve of the receiving tube when red blood cells carry oxygen molecules.

A new model based on ray tracing is developed to estimate power spectral properties in laser Doppler velocimetry of retinal vessels and to predict the effects of laser beam size and eccentricity as well as absorption of laser light by oxygenated and reduced hemoglobin. There is described the model and show that it correctly converges to the traditional rectangular shape of the Doppler shift power spectrum, given the same assumptions, and that reduced beam size and eccentric alignment cause marked alterations in this shape. The changes in the detected total power of the Doppler-shifted light due to light scattering and absorption by blood can also be quantified with this model and may be used to determine the oxygen saturation in retinal arteries and veins. The potential of this approach is that it uses direct measurements of Doppler signals originating only from moving red blood cells. The invention opens new avenues for retinal vessel oximetry.

The present invention discloses a method and a device for accurately measuring blood oxygen saturation based on a photoacoustic technology. The method comprises the following steps: exciting light source to emit two beams of light with different specific wavelengths, irradiating surfaces of tissues to be measured through an optical system, also conducting penetration into the tissues to enable oxygenated hemoglobin and reduced hemoglobin in the tissues to be measured to absorb the light beams to generate ultrasonic signals, collecting ultrasonic signals by using an ultrasonic signal acquisition module and measuring the ultrasonic signals, processing the ultrasonic signals by using an ultrasonic signal processing module, acquiring relative concentration of the oxygenated hemoglobin and reduced hemoglobin in blood by an image reconstruction algorithm and calculating absolute value of blood oxygen saturation of the blood of the tissues to be measured based on the relative value of the relative concentration. The provided measurement method has higher measurement accuracy than the existing blood oxygen saturation measuring instrument technology and at the same time solves a technical problem that the existing blood oxygen instrument cannot measure the blood oxygen saturation in venous blood vessels.

A near-infrared brain-machine interface signal detection method integrating independent component analysis and least square method belongs to the technical field of hemoglobin concentration detection, and solves the problems that oxyhemoglobin concentration change and reduced hemoglobin concentration variation obtained via detection are not exact in the near-infrared brain-machine interface detection due to human physiological interference, thereby influencing the accurate extraction of brain function activity signal. Through the signal detection method, diffuse reflection light intensities are recorded when the brain is in resting state and in induced motivation with a detector, so as to obtain time sequences of Delta OD<lambda1><N> (k) and Delta OD<lambda2><N> (k), Delta OD<lambda1><F> (k) and Delta OD<lambda2><F> (k); then the Delta [HbO2]<N> (k), Delta [HHb]<N> (k), Delta [HbO2]<F> (k) and Delta [HHb]<F> (k) are obtained; the x1(k) is used for representing the Delta [HbO2]<N> (k) or the Delta [HHb2]<N> (k) in the step 2; the x2(k) is used for representing the Delta [HbO2]<F> (k) or Delta [HHb]<F> (k) in the step 2; the brain function signal expression s(k) is calculated; and the brain function signal s(k) is solved. The near-infrared brain-machine interface signal detection method is suitable for signal detection of brain-machine interface.

The invention discloses a three-wavelength vein blood oxygen concentration measuring method, a measuring device is composed of a blood oxygen signal, a blood oxygen probe, a signal amplifier, an analog-digital converter and a main controller, the blood oxygen probe collects a blood sample signal, carries out photoelectric conversion, converts a light intensity signal into a frequency signal, carries out signal amplification through a signal amplification circuit, performs ADC conversion, converts the frequency signal into a digital signal, transmits the digital signal to the main controller, the digital signal is processed by the main controller to obtain an electric signal in direct proportion to the light intensity, and the obtained electric signal is substituted into a three-wavelength calculation formula obtained by new derivation to obtain the corresponding venous blood oxygen concentration. According to the three-wavelength vein blood oxygen concentration measuring method, wavelength light sources on absorption points such as reduced hemoglobin and oxyhemoglobin serve as reference light sources, the three-wavelength vein blood oxygen concentration measuring method is obtained through derivation, the anti-interference capacity is higher, measurement is accurate, no time interval is generated in the measuring period, and real-time, continuous and effective parameters can be provided.

Pulse waves of a living body are detected with high accuracy. A pulse wave detection device includes a camera configured to capture an image of the living body a plurality of times through a first green filter and an infrared light filter having light transmission characteristics in a near-infrared light wavelength range within a wavelength range where a light absorption coefficient of oxidized hemoglobin is greater than a light absorption coefficient of reduced hemoglobin, and an image analysis unit configured to analyze a plurality of images of the living body captured by the camera and to detect the pulse waves of the living body. The image analysis unit is configured to detect the pulse waves by detecting a change in intensity of light in the near-infrared light wavelength range indicated by the plurality of images.

Pulse waves of a living body are detected with high accuracy. A pulse wave detection device includes a camera configured to capture an image of the living body a plurality of times through a first green filter and an infrared light filter having light transmission characteristics in a near-infrared light wavelength range within a wavelength range where a light absorption coefficient of oxidized hemoglobin is greater than a light absorption coefficient of reduced hemoglobin, and an image analysis unit configured to analyze a plurality of images of the living body captured by the camera and to detect the pulse waves of the living body. The image analysis unit is configured to detect the pulse waves by detecting a change in intensity of light in the near-infrared light wavelength range indicated by the plurality of images.

A new model based on ray tracing is developed to estimate power spectral properties in laser Doppler velocimetry of retinal vessels and to predict the effects of laser beam size and eccentricity as well as absorption of laser light by oxygenated and reduced hemoglobin. There is described the model and show that it correctly converges to the traditional rectangular shape of the Doppler shift power spectrum, given the same assumptions, and that reduced beam size and eccentric alignment cause marked alterations in this shape. The changes in the detected total power of the Doppler-shifted light due to light scattering and absorption by blood can also be quantified with this model and may be used to determine the oxygen saturation in retinal arteries and veins. The potential of this approach is that it uses direct measurements of Doppler signals originating only from moving red blood cells. The invention opens new avenues for retinal vessel oximetry.