Biological tissue blood flow, blood oxygen and blood volume multi-parameter detection method and device

Abstract

The invention discloses a biological tissue blood flow, blood oxygen and blood volume multi-parameter detection method and device. According to the method, two laser beams, differing in wavelength, simultaneously irradiate a biological tissue; and multiple frames of biological tissue colored images, which are illuminated by the laser beams, are continuously acquired by a photoelectric imaging system. The light intensity values of a red channel and a green channel on each pixel of the images are obtained for respectively constituting a red channel image and a green channel image. By virtue of a laser speckle blood flow imaging data analysis method and a dual-wavelength spectroscopic data analysis method, the red channel image and the green channel image are processed, so that two-dimensional spatial distribution and dynamic variation information thereof of a plurality of physiological parameters including blood flow, oxyhemoglobin concentration and reduced hemoglobin concentration of the corresponding biological tissue are obtained. The method and the device disclosed by the invention solve the shortcoming that a multi-wavelength time-sharing imaging based multi-parameter blood flow imaging system has difficulty in achieving the synchronization of accurate time and also avoid the shortcoming that a multi-camera shooting based multi-parameter blood flow imaging system is high in cost due to the use of a plurality of cameras.

Description

technical field [0001] The patent of the present invention belongs to the field of biomedical imaging, and specifically relates to an easy-to-use and low-cost multi-parameter detection method and device, which can realize real-time imaging of multiple hemodynamic information of biological tissues such as human skin and cerebral cortex, and Continuous monitoring. Background technique [0002] The multi-parameter monitoring of biological tissue hemodynamics is very important for studying the physiological state of living organisms. The general multi-parameter blood flow imaging system is realized by combining basic optical imaging methods such as various fluorescence imaging, endogenous signal optical imaging and laser speckle blood flow imaging, and these optical imaging are achieved by using incoherent or coherent The light source irradiates biological tissue, collects its reflected light, and analyzes the reflected light information to obtain hemodynamic parameters. Howev...

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Problems solved by technology

[0006] This system uses a beam splitter and an optical filter to split the reflected light carrying the signal according to different wavelengths, and then collects it with multiple monochrome cameras. This method can avoid time-sharing acquisition of multi-wavelength signals. However, this method requires the design of special optical and mechanical structures to ensure accurate registration between images obtained by different cameras, and the cost is relatively high.

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