This application discloses a method, device, and medium for reconstructing the absorption coefficient of
biological tissue, relating to the field of tissue optical parameter measurement. The method includes: segmenting a time-resolved
analog signal and a measured
signal according to a preset time window segmentation rule; constructing a depth-time window
coupling weight matrix based on the time window and
photon path information; determining the overall error based on the simulated value sequence, the measured value sequence, and the depth-time window
coupling weight matrix; determining whether the overall error meets a preset iteration termination condition; if not, updating the sensitivity matrix based on the
photon path information, and iteratively updating the current absorption coefficient using the depth-time window
coupling weight matrix and the sensitivity matrix; determining a new time-resolved
analog signal based on the updated absorption coefficient and
photon path information; and continuing until the preset iteration termination condition is met. This application can improve the reliability, accuracy, and practicality of absorption coefficient reconstruction.