Non-invasive measurement method of hemoglobin concentration based on the principle of optical reflection

A technology of hemoglobin concentration and optical reflection, which is applied in the field of non-invasive measurement of hemoglobin concentration based on the principle of optical reflection, can solve the problems of increased infection of patients, inability to monitor in real time, and long time consumption

Active Publication Date: 2021-04-30
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the traditional hemoglobin detection method is to use an invasive method to collect blood from the detection site. This method can achieve accurate measurement, but it will bring pain to the patient and increase the chance of infection. At the same time, the detection cost of the invasive method is relatively low. High, takes a long time, and has the disadvantage of being unable to monitor in real time
In addition, mature non-invasive detection methods can only obtain blood oxygen saturation SpO 2 , less involving real-time monitoring of hemoglobin concentration, SpO 2 It simply expresses the percentage of the capacity of oxyhemoglobin to the total capacity of hemoglobin that can be combined

Method used

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  • Non-invasive measurement method of hemoglobin concentration based on the principle of optical reflection
  • Non-invasive measurement method of hemoglobin concentration based on the principle of optical reflection
  • Non-invasive measurement method of hemoglobin concentration based on the principle of optical reflection

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Experimental program
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Effect test

Embodiment 1

[0060] Embodiment 1: as Figure 1 ~ Figure 2 As shown, a non-invasive measurement method of hemoglobin concentration based on the principle of optical reflection, comprising the following steps:

[0061] Step 1: setting a light source on the outer layer of human skin tissue, said light source respectively emitting near-infrared incident light with wavelengths of λ1 and λ2; setting two sets of photodetectors on both sides of the light source;

[0062] The first group of photodetectors includes a first photodetector and a second photodetector, and the second group of photodetectors includes a third photodetector and a fourth photodetector; the first photodetector and The distance from the second photodetector to the light source is r 1 ; The distance between the third photodetector and the fourth photodetector to the light source is r 2 ;

[0063] Step 2: Obtain the absorbance A of the incident light emitted by the light source after being reflected by the human skin tissue, ...

Embodiment 2

[0080] Embodiment 2: Another non-invasive method for measuring hemoglobin concentration based on the principle of optical reflection, comprising the following steps:

[0081] Step 1: set a light source on the outer layer of human skin tissue, and the light source emits near-infrared incident light with wavelengths λ1 and λ2 respectively; two sets of photodetectors are set on both sides of the light source; specifically, the λ1 is 660nm, The λ2 is 850nm;

[0082] The first group of photodetectors includes a first photodetector and a second photodetector, and the second group of photodetectors includes a third photodetector and a fourth photodetector; the first photodetector and The distance from the second photodetector to the light source is r 1 ; The distance between the third photodetector and the fourth photodetector to the light source is r 2 ; the r 1 and r 2 Satisfy the following relation: 01 -r 2 )<10mm; the included angles formed by the connection lines between tw...

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Abstract

The invention discloses a non-invasive measurement method of hemoglobin concentration based on the principle of optical reflection, comprising: setting a light source and a photoelectric detector; determining the relationship between the absorbance and the concentration of oxygenated hemoglobin and the concentration of reduced hemoglobin in hemoglobin in deep tissue; and emitting wavelength of the light source The near-infrared incident light of λ1 and λ2, the first photodetector and the third photodetector obtain the absorbance after reflection of human skin tissue respectively; the light source emits near-infrared incident light with wavelengths of λ1 and λ2, and the second photodetector and the fourth photodetector respectively obtain the absorbance reflected by the human skin tissue; the correction coefficient is introduced ω 1 and ω 2 , to obtain the concentration of oxygenated hemoglobin and the concentration of reduced hemoglobin in the deep tissue respectively; add the two concentrations to obtain the concentration of hemoglobin in the deep tissue wxya . The invention realizes noninvasive measurement of hemoglobin concentration, has low measurement cost and high measurement accuracy.

Description

technical field [0001] The invention relates to the technical field of medical measurement, in particular to a noninvasive method for measuring hemoglobin concentration based on the principle of optical reflection. Background technique [0002] The human body contains a large number of red blood cells, which can transport oxygen to all parts of the body. Its function is mainly completed by hemoglobin in red blood cells; Life activities are of great significance. At present, the traditional hemoglobin detection method is to use an invasive method to collect blood from the detection site. This method can achieve accurate measurement, but it will bring pain to the patient and increase the chance of infection. At the same time, the detection cost of the invasive method is relatively low. High, time-consuming, and has the disadvantage of being unable to monitor in real time. In addition, mature non-invasive detection methods can only obtain blood oxygen saturation SpO 2 , less...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/1455
CPCA61B5/1455
Inventor 张锦龙员琳贺静尤贺韩笑笑
Owner HENAN UNIVERSITY
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