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Method for testing absolute volume of concentration of oxidized hemoglobin and reduced hemoglobin in human tissue

A technology of hemoglobin concentration and human tissue, which is applied in the field of biomedical engineering, can solve problems such as unobtainable results, and achieve the effects of improving detection sensitivity, easy circuit, and stable measurement

Active Publication Date: 2009-07-29
TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In principle, direct application of the classical Lambert-Beer law under strong scattering does not yield any correct results

Method used

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  • Method for testing absolute volume of concentration of oxidized hemoglobin and reduced hemoglobin in human tissue
  • Method for testing absolute volume of concentration of oxidized hemoglobin and reduced hemoglobin in human tissue
  • Method for testing absolute volume of concentration of oxidized hemoglobin and reduced hemoglobin in human tissue

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Embodiment Construction

[0035] The step (1) of the non-destructive detection of the absolute concentration of oxygenated and reduced hemoglobin includes the following steps in sequence:

[0036] Place the two photoelectric receiving tubes OPUS1, OPUS2 and the light sources LS with 3 emission wavelengths at appropriate positions.

[0037] The step (2) of the non-destructive detection of the absolute concentration of oxygenated and reduced hemoglobin includes the following steps in sequence:

[0038] The microcontroller drives the light source to emit light of three different wavelengths in time, and uses OPUS1 and OPUS2 to measure the corresponding scattered light intensity within 0.5ms in sequence ( image 3 );

[0039] Use the formula of optical density to calculate the optical density at different detection distances :

[0040] OD k λ i = log I 0 ...

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Abstract

The invention belongs to the technical field of biomedical engineering, and is characterized in that: the sensor is composed of two photoelectric receiving tubes and at least three light sources with different light-emitting wavelengths, based on the different spectral characteristics of oxygenated and reduced hemoglobin and tissue background in tissue oxygen metabolism, According to the law of light absorption and scattering in tissues, the concentration of oxygenated and reduced hemoglobin in local tissues is calculated. The light sources with at least three wavelengths and the two photoelectric receiving tubes are arranged in a straight line at a certain distance, and the light sources can respectively emit red light and near-infrared light. It can sensitively detect the absolute amount of oxygenated and reduced hemoglobin in human tissue.

Description

technical field [0001] The invention relates to a method for detecting the absolute amount of human tissue oxygenation and reduced hemoglobin concentration, which belongs to the technical field of biomedical engineering. Background technique [0002] Detecting the concentration of tissue oxygenation and reduced hemoglobin, and observing its change over time, is helpful to understand the blood volume of local tissues in patients with hypoxic-ischemic encephalopathy and during surgery. [0003] Methods for determining the oxygen metabolism of human tissues mainly include invasive detection methods for the human body and non-destructive detection methods based on optical measurement. The optical method can realize non-invasive monitoring, which is convenient and safe to use, stable and reliable. The invention belongs to a kind of optical method. The method described in the document with the publication number CN 1365649A is based on the classic Lambert-Beer law, which is for ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/1455G01N21/17G06F17/00
Inventor 丁海曙黄岚腾轶超李岳
Owner TSINGHUA UNIV
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