Method for preparing core-shell structure drug carrier with near-infrared light remote response and application thereof
A core-shell structure and near-infrared light technology, applied in the field of biomedical materials, can solve the problems of high risk, shallow penetration depth of light source, and high cost, and achieve strong penetration and inhibit the formation of atherosclerotic plaques Effect
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specific Embodiment approach 1
[0024] Embodiment 1: The preparation method of a drug carrier with a core-shell structure with near-infrared light remote response in this embodiment is specifically carried out according to the following steps:
[0025] 1. NaYF 4 : Yb / Er upconversion nanoparticles are dispersed in cyclohexane to obtain upconversion nanoparticle cores;
[0026] 2. Add dicyclohexylcarbodiimide, chlorin e6 and 3-aminopropyltriethoxysilane successively to N,N-dimethylformamide solvent to obtain a mixed solution, and place the mixed solution at room temperature Stand still for 24 hours to obtain a photosensitizer condensation solution; the volume ratio of the mass of the dicyclohexylcarbodiimide to the N,N-dimethylformamide solvent is 1mg:(1.5~2)mL; the dihydrogen The volume ratio of the mass of porphyrin e6 to N,N-dimethylformamide solvent is 1mg:(0.5~0.8)mL; the 3-aminopropyltriethoxysilane and N,N-dimethylformamide The volume ratio of amide solvent is 1:(180~220);
[0027]3. Add cetyltrimeth...
specific Embodiment approach 2
[0031] Embodiment 2: This embodiment differs from Embodiment 1 in that the volume ratio of the mass of dicyclohexylcarbodiimide to the solvent of dicyclohexylcarbodiimide in step 2 is 1 mg:1.7 mL. Other steps and parameters are the same as those in the first embodiment.
specific Embodiment approach 3
[0032] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the volume ratio of the mass of chlorin e6 described in step 2 to the dicyclohexylcarbodiimide solvent is 1 mg:0.625 mL. Other steps and parameters are the same as those in Embodiment 1 or 2.
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