Method for preparing core-shell structure drug carrier with near-infrared light remote response and application thereof

A core-shell structure and near-infrared light technology, applied in the field of biomedical materials, can solve the problems of high risk, shallow penetration depth of light source, and high cost, and achieve strong penetration and inhibit the formation of atherosclerotic plaques Effect

Inactive Publication Date: 2015-07-22
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims to solve the problems of shallow penetration depth, high cost and high risk of traditional photodynamic therapy light sources for atherosclerosis, and provides a method for preparing a drug carrier with a core-shell structure that responds remotely to near-infrared light. its application

Method used

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  • Method for preparing core-shell structure drug carrier with near-infrared light remote response and application thereof
  • Method for preparing core-shell structure drug carrier with near-infrared light remote response and application thereof
  • Method for preparing core-shell structure drug carrier with near-infrared light remote response and application thereof

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Experimental program
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specific Embodiment approach 1

[0024] Embodiment 1: The preparation method of a drug carrier with a core-shell structure with near-infrared light remote response in this embodiment is specifically carried out according to the following steps:

[0025] 1. NaYF 4 : Yb / Er upconversion nanoparticles are dispersed in cyclohexane to obtain upconversion nanoparticle cores;

[0026] 2. Add dicyclohexylcarbodiimide, chlorin e6 and 3-aminopropyltriethoxysilane successively to N,N-dimethylformamide solvent to obtain a mixed solution, and place the mixed solution at room temperature Stand still for 24 hours to obtain a photosensitizer condensation solution; the volume ratio of the mass of the dicyclohexylcarbodiimide to the N,N-dimethylformamide solvent is 1mg:(1.5~2)mL; the dihydrogen The volume ratio of the mass of porphyrin e6 to N,N-dimethylformamide solvent is 1mg:(0.5~0.8)mL; the 3-aminopropyltriethoxysilane and N,N-dimethylformamide The volume ratio of amide solvent is 1:(180~220);

[0027]3. Add cetyltrimeth...

specific Embodiment approach 2

[0031] Embodiment 2: This embodiment differs from Embodiment 1 in that the volume ratio of the mass of dicyclohexylcarbodiimide to the solvent of dicyclohexylcarbodiimide in step 2 is 1 mg:1.7 mL. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0032] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the volume ratio of the mass of chlorin e6 described in step 2 to the dicyclohexylcarbodiimide solvent is 1 mg:0.625 mL. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a method for preparing a core-shell structure drug carrier with near-infrared light remote response and an application thereof, belongs to the field of biomedical materials, and particularly discloses a method for preparing a core-shell structure drug carrier with near-infrared light remote response and an application thereof. The invention aims at solving the problems of shallow light source penetration depth, high cost and big risk of the current atherosclerosis traditional photodynamics therapy. The method comprises the following steps: firstly synthesizing a core-shell structure nano-particle coated with a photosensitizer, wherein the nano-particle is swallowed by the cell in the cell co-culture process; and radiating the cell by near-infrared light, wherein under the stimulation of the near-infrared light, the nano-particle in the cell is acted with the tissue oxygen to generate a cytotoxic active oxygen molecule singlet oxygen (1O2) so as to kill the cell till apoptosis. The core-shell structure drug carrier with near-infrared light remote response prepared by the invention is taken as a medical carrier for inhibiting and killing the atherosclerosis plaque cell.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method and application of a drug carrier with a core-shell structure with near-infrared light remote response. Background technique [0002] In recent years, with the improvement of people's living standards, the incidence of cardiovascular and cerebrovascular diseases such as atherosclerosis remains high, and has become the second largest killer after cancer to threaten human health. The main pathological change of atherosclerosis is the formation of a large number of plaques in blood vessels, and the sudden rupture of some plaques is an important cause of cardiovascular and cerebrovascular diseases such as myocardial infarction and stroke. How to inhibit the formation of plaques and discover and eliminate unstable plaques through early diagnosis is the key to the prevention and treatment of cardiovascular and cerebrovascular diseases. [0003] At p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/48A61P9/10
Inventor 王浩王铀
Owner HARBIN INST OF TECH
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