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Applications of poultry bile conversion product in preparing medicines for resisting cholestatic liver diseases

A technology of cholestasis and transformation, which is applied in the direction of drug combination, digestive system, and pharmaceutical formula, which can solve the problems of anti-cholestasis that has not been disclosed, and achieve the effect of improving cholestasis, high pharmacological activity, and reducing the degree of liver tissue damage

Pending Publication Date: 2018-11-30
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chicken gall extract composition provided by this method only discloses the digestive system, gallstone-dissolving effect and choleretic effect, and does not disclose its anti-cholestasis effect

Method used

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  • Applications of poultry bile conversion product in preparing medicines for resisting cholestatic liver diseases
  • Applications of poultry bile conversion product in preparing medicines for resisting cholestatic liver diseases
  • Applications of poultry bile conversion product in preparing medicines for resisting cholestatic liver diseases

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Experimental program
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Effect test

Embodiment 1

[0071] This embodiment prepares the chicken bile transformant according to the preparation method disclosed in CN104382941A

[0072] 1. Preparation of chicken gall powder

[0073] Chicken guts are purchased from slaughterhouses. First determine the number and weight of gallbladder. Use 75% alcohol to sterilize part of the chicken gall, and then dissect the bile separately. The taken out bile was freeze-dried for 48 hours to obtain chicken bile powder, which was stored in a desiccator for subsequent use.

[0074] 2. Preparation of chicken bile transformant

[0075] (1) Processing of chicken gall powder

[0076] Prepare 20L of phosphate buffered saline (PBS) with a pH value of 7.0-9.0 and ultrasonically dissolve 140-150g of chicken gall powder to obtain a chicken gall powder solution, and fully dissolve the chicken gall powder solution; centrifuge the chicken gall powder solution at 11000g for 10 minutes, and then 3-5 times Filter, and store the filtrate as poultry gall pow...

Embodiment 2

[0084] Healthy male C57BL / 6J mice, weighing 20±2g, were provided by Shanghai Slack Experimental Animal Co., Ltd. The mice were randomly divided into normal control group, model control group (with cholestatic liver disease), ursodeoxycholic acid positive control group, chicken bile conversion low, middle and high dose administration groups (administration doses were 0.1 g / kg, 0.2g / kg, 0.4g / kg). The positive control group was given ursodeoxycholic acid UDCA (dissolved in PBS) by intragastric administration at 115 mg / kg, the normal control group and the model control group were given intragastric administration of the same volume of normal saline, and the low, medium and high dose administration groups of chicken bile conversion 0.1g / kg, 0.2g / kg and 0.4g / kg of chicken bile conversion products (dissolved in normal saline) were given by intragastric administration once a day for 14 consecutive days. 4 hours after administration on the 12th day of the test, except the normal contr...

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Abstract

The invention provides applications of a poultry bile conversion product in preparing medicines for resisting cholestatic liver diseases. The research shows that the poultry bile conversion product has the effects of improving cholestasis and alleviating liver injuries for a model mouse with the cholestatic liver diseases, can effectively reduce the levels of serum glutamic pyruvic transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bile acid (TBA), cholesterol and total bilirubin (TBIL) of the model mouse, can alleviate the degree of the liver tissue injuries, and has the effect of resisting cholestatic liver diseases. The invention discloses the applications of the poultry bile conversion product in preparing the medicines for resisting cholestatic liver diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to the application of poultry bile conversion products in the preparation of anti-cholestasis liver disease drugs. Background technique [0002] Cholestasis refers to the disorder of bile flow formation, secretion and excretion. The bile flow cannot flow into the duodenum normally, but stays in the liver and enters the blood circulation. Most of them belong to intrahepatic cholestasis, which is common in various chronic liver diseases, also known as cholestatic liver disease. As the disease progresses, intrahepatic cholestasis can aggravate liver damage, and severe cases can lead to liver failure or even death. For intrahepatic cholestasis, clinical treatment drugs are still insufficient, and there is an urgent need to develop new therapeutic drugs. [0003] Intrahepatic cholestasis belongs to the category of "jaundice" in traditional Chinese medicine. In the long-term c...

Claims

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Application Information

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IPC IPC(8): A61K35/57A61P1/16
CPCA61K35/57A61P1/16A61K2300/00
Inventor 马越鸣吴家胜杨莉王峥涛李一飞王天明张小利张振华李坤
Owner SHANGHAI KAIBAO PHARMA
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