34 results about "Engelhardia roxburghiana" patented technology

The invention provides a traditional Chinese medicine extractive used for preventing and treating autoimmune diseases. The extract is prepared by extracting roxburgh engelhardtia leaves and purifying with macroporous resin, and can be used for preventing and treating autoimmune diseases, particularly for preventing and treating rheumatoid arthritis and other autoreactive T cell-mediated autoimmune diseases.

The invention relates to a method for extracting astilbin and dihydroquercetin from engelhardia roxburghiana wall leaves and application of extractives thereof. The method for extracting the astilbin from the engelhardia roxburghiana wall leaves comprises the steps of: extracting by refluxing ethanol, degreasing by using ligarine, extracting by using ethyl acetate, blending two organic solvents with different polarities in proportion, and performing recrystallization so as to obtain the astilbin; and the method for extracting the dihydroquercetin from the engelhardia roxburghiana wall leaves mainly comprises the steps of: firstly, obtaining the astilbin by using the provided method, and then hydrolyzing the astilbin to obtain the dihydroquercetin. The methods provided by the invention are beneficial to simplification of the traditional operation processes such as resin absorption, polyamide column or silicagel column chromatography and the like, and have the characteristics of simple, convenient and feasible process, simplicity for operation, lower cost and higher extraction efficiency and content; and after being measured with the HPLC (High Performance Liquid Chromatography) method, the contents of the astilbin and the dihydroquercetin are both more than 90%, therefore the method is suitable for industrialized production.

The invention relates to a method for preparing dihydro quercetin, which comprises the following steps of: pulverizing engelhardia roxburghiana wall leaves serving as raw materials, adding acidulous water for wetting, adding naringinase and keeping the temperature constant for enzymolysis; performing refluxing extraction in ethanol; adding polyamide resin into concentrated solution for adsorbing, performing gradient elution in ethanol and the water, and concentrating eluent for crystallizing; and performing recrystallization by using the water and 70 percent ethanol, and performing vacuum drying at the low temperature to obtain dihydro quercetin. In process, reagents have no toxic properties, and the process flow is simple; and the dihydro quercetin produced by the process can be used as raw materials of health-care products and medicines directly.

The invention belongs to the field of natural medicinal chemistry and specifically relates to a preparation method of taxifolin. The preparation method comprises the following steps: taking 10 parts by weight of Engelhardia roxburghiana Wall leaf, adding 2-10 parts by volume of a 30-90% ethanol solution to extract, and carrying out vacuum concentration on an extract to obtain an extract product A; purifying through macroporous resin, using ethanol as a mobile phase A and using water as a mobile phase B to carry out gradient elution, detecting by HPLC, and collecting to obtain an extract product B; dissolving in 1-8% organic acid-containing ethanol and/or water, and stirring and hydrolyzing at 80-100 DEG C to obtain a hydrolysate C; neutralizing to pH5-6 by adding 0.01-0.05M of alkali liquor, carrying out vacuum concentration on the neutralization solution, standing at room temperature for 5-24 h, filtering, and collecting filter cake to obtain a precipitate D; and recrystallizing to obtain taxifolin. The relation of part by weight and part by volume is g/L. According to the invention, organic acid used for acid hydrolysis is optimized such that acid used for acid hydrolysis is recycled and reused. Therefore, corrosion to equipment is reduced, and production cost is decreased. By optimizing steps after acid hydrolysis, the separation and purification period is shortened and operations are simplified, thus being more beneficial to industrial production.

The invention discloses a process for extracting astilbin from Engelhardia roxburghiana Wall leaves, and belongs to the technical field of extraction of active ingredients from Engelhardia roxburghiana Wall leaves. The astilbin is prepared by the following steps: pulverizing, first decolorizing, coarse crystallization, second decolorizing, separation and purification by macroreticular resin, concentration and crystallization, drying and the like. The extraction yield of the prepared astilbin is 65.48% or above, the purity is 98.16% or above, and the extraction yield and the purity are higher than the extraction yield and the purity of the astilbin prepared in the prior art.

The invention discloses medicinal granules for treating spleen-qi deficiency type diarrhea associated with menstruation. The traditional Chinese medicine components of the medicinal granules consist of the following raw medicinal materials in parts by weight: 15-33 parts of ginseng, 10-30 parts of herb of rose glorybind, 15-25 parts of rhizome of tendrilleaf solomonseal, 20-40 parts of largehead atractylodes rhizome, 10-25 parts of glossy privet fruit, 10-20 parts of common hawksbeard, 8-16 parts of tuner onion seed, 10-20 parts of black sesame, 6-12 parts of elsholtzia rugulosa, 10-20 parts of licorice root, 6-16 parts of engelhardia roxburghiana, 8-16 parts of cardamom, 6-12 parts of chalk, 8-16 parts of dark plum fruit, 6-14 parts of pomegranate rind, 6-16 parts of dried ginger, 6-14 parts of flower of hyacinth dolichos, 8-16 parts of Chinese date, 8-16 parts of rock candy and 6-14 parts of rhizome of swordlike atractylodes. The medicinal granules disclosed by the invention are clear and definite in curative effect on the spleen-qi deficiency type diarrhea associated with menstruation and strong in symptomatic treatment effect, and are specially used for treating special diseases, and active ingredients in the medicinal granules can be quickly absorbed, so that the medicinal granules are quick and effect and have very good effect of conditioning bodies.

The invention discloses a Chinese herbal medicine disinfectant for pigpen disinfection. The disinfectant is prepared from the following raw materials in parts by weight: 14-16 parts of ligusticum wallichii, 14-16 parts of bighead atractylodes rhizome, 2-3 parts of bamboo leaves, 2-3 parts of rhizoma phragmitis, 28-32 parts of engelhardia roxburghiana, 28-32 parts of anisetree bark, 10-14 parts of plant soot, 10-14 parts of seville orange flowers, 10-14 parts of ammophila arenaria, 5-6 parts of gomphrena globosa, 5-6 parts of golden larch bark, 16-20 parts of folium apocyni veneti, 16-20 parts of houttuynia cordata, 4-8 parts of banana peel, 2-3 parts of eggshells, 8-10 parts of glutinosae rice roots and 14-16 parts of aids. The disinfectant disclosed by the invention is long in drug property duration and does not cause harm to health of pigs; during disinfection, the pigs do not need to be driven out of the pigpen, and the disinfectant is directly spread into the pigpen. Due to use of the disinfectant disclosed by the invention, the cleaning frequency of the pigpen is reduced, the manual cost is greatly saved, and the disinfectant has an excellent effect of inhibiting reproduction of bacteria and microbes. Moreover, the disinfectant has an excellent effect of absorbing odor in the pigpen and is small in usage amount and low in manufacturing cost, and compared with disinfectants used in the past years, the disinfectant disclosed by the invention has the advantage that the expense of disinfection supplies can be saved by 60%.

The invention relates to application of engelhardia roxburghiana extract in preparing a medicament for treating cholestatic liver disease. The engelhardia roxburghiana extract ER and ER-A2 have certain FXR activating action, and the engelhardia roxburghiana extract ER-A3 and ER-B2 have relatively strong activating action on FXR and can be directly used as a farnesol X receptor agonist. In addition, the engelhardia roxburghiana extract ER-A3 and ER-B1 prepared by the invention have remarkable inhibiting action on activity rise of Tbil, ALT, APL and gamma-GT caused by cholestasis induced by ANIT, obviously improve the hepatocyte damage, inflammatory cell infiltration and bile excretion caused by ANIT and have relatively good therapeutic action on cholestatic liver disease, and can be used as a potential drug for treating cholestatic liver disease.

The invention provides water body improvement liquid for a crucian fishpond. The water body improvement liquid is prepared from the following raw materials in parts by weight: 18-35 parts of tangerine peels, 18-35 parts of tribulus terrestris, 18-30 parts of lotus rhizome knots, 8-15 parts of bulbus fritillariae cirrhosae, 8-15 parts of engelhardia roxburghiana, 2-3 parts of logwood, 13-25 parts of peach juice, 3-8 parts of plant alkaloid, 3-8 parts of wild chrysanthemum flowers, 0.5-1 part of modified vitamins and 0.5-1 part of modified carotenoids. The water body improvement liquid provided by the invention contains abundant calcium and phosphorus elements, vitamins and carotenoids and also contains a plurality of types of microelements, so that the growth requirements of crucian can be sufficiently guaranteed and the water body improvement liquid has no irritation; injuries to skins and esophagus of the crucian are not caused; meanwhile, the breeding of undesired microbes in a water body can also be inhibited and the water body improvement liquid can also help the water body to dissolve oxygen; and when the water body improvement liquid provided by the invention is used, the management time and process can be greatly saved.

The invention discloses a watermelon peel vinegar beverage capable of clearing summer-heat. The watermelon peel vinegar beverage is made of the following components including, by weight, 30-40 parts of fresh watermelon peels, 10-15 parts of sauropus androgynus, 9-11 parts of nymphoides hydrophylla, 13-15 parts of ficus tikoua fruits, 5-7 parts of E cheiranthoides, 3-7 parts of sweet potato seeds, 6-9 parts of engelhardia roxburghiana, 8-13 parts of mung beans, 4-7 parts of sweet-scented osmanthus, 15-20 parts of sugarcane, 0.1-0.3 part of preservative, 60-70 parts of table vinegar and 0.2-0.4 part of acidity regulator. The watermelon peel vinegar beverage contains various ingredients for clearing summer-heat, and is remarkable in effect and unique in taste.

The invention discloses a quality detection method of Engelhardia roxburghiana wall dried leaves, which comprises the steps of carrying out qualitative analysis on theEngelhardia roxburghiana wall dried leaves by using thin-layer chromatography, forecasting by using the advantages of trace, rapidness and simplicity of the thin-layer chromatography, carrying out quantitative analysis by using high performance liquid chromatography, carrying out quantitative analysis by combining a one-marker multi-evaluation method based on a high performance liquid chromatography technology, taking the astilbin reference substance as a reference, and measuring the contents of six components including astilbin, astilbin, neoisoastilbin, iso-astilbin, quercitrin and engelhardia roxburghiana glycoside in theEngelhardia roxburghiana wall dried leaves at the same time. The cost is low, the time is short, the operation is simple and convenient, and the detection result is relatively accurate. Qualitative analysis and quantitative analysis are carried out on the Engelhardia roxburghiana wall dried leaves through the quality detection method, and a foundation is laid for quality standard establishment of the Engelhardia roxburghiana wall dried leaves.

The preparation method comprises the following steps: adding a chitosan solution into an engelhardia roxburghiana total flavone aqueous solution while stirring, then injecting a sodium tripolyphosphate aqueous solution, carrying out an ion exchange reaction until blue opalescence appears, then adding a chitosan solution into the engelhardia roxburghiana total flavone aqueous solution while stirring, and carrying out an ion exchange reaction to obtain the chitosan engelhardia roxburghiana total flavone nanoparticle. And carrying out rotary evaporation concentration and spray drying on the suspension to obtain the chitosan engelhardia roxburghiana total flavonoid nanoparticle, and carrying out spray drying on the suspension to obtain the chitosan engelhardia roxburghiana total flavonoid nanoparticle. The chitosan engelhardia roxburghiana total flavone nanoparticles prepared by adopting an ionic cross-linking method are spherical, have the size of 100-300nm and have a slow release effect.

The invention discloses an extraction technology of Engelhardia roxburghiana Wall leaf astilbin, and belongs to the technical field of extraction of natural product effective components. The technology comprises the following steps: crushing Engelhardia roxburghiana Wall leaves to form crude powder, carrying out reflux extraction by using 80% ethanol, carrying out decolorizing and impurity removal on obtained extract through active carbon, and filtering the obtained extract to obtain a primarily decolorized liquid; carrying out vacuum reduced pressure concentration on the primarily decolorized liquid, crystallizing the obtained concentrate, and washing obtained crystals with distilled water until the crystals are colorless in order to obtain crude crystals; dissolving the crude crystals in hot alcohol, and carrying out decolorizing and impurity removal on the obtained alcohol solution by using active carbon to obtain a secondarily decolorized liquid; and filtering and concentrating the secondarily decolorized liquid, crystallizing the obtained concentrate at a low temperature, and drying the obtained crystals to prepare 90-96% astilbin. The extraction technology of Engelhardia roxburghiana Wall leaf astilbin has the advantages of low cost of above raw material, simple operating process, full extraction of effective components in the Engelhardia roxburghiana Wall leaves, realization of high purity of the prepared astilbin, and increase of the utilization rate of the raw material.

The invention discloses a traditional Chinese medicine for treating arthralgia and scleromere pain, and mainly solves the problems that: in the prior art, methods for treating arthralgia and scleromere pain comprise fumigation, medicine application, acupoint injection therapy, kinesitherapy, western medicines and the like, western medicines have obvious adverse reactions, and other methods are long in treatment course and not obvious in curative effect. The traditional Chinese medicine for treating arthralgia and scleromere pain is prepared from the following components in parts by weight: 1-3parts of safflower, 4-6 parts of common aucklandia roots, 4-6 parts of Chinese angelica root-tip, 3-5 parts of Sichuan lovage rhizomes, 2-4 parts of engelhardia roxburghiana, 3-5 parts of eucommia ulmoides, 4-6 parts of radix paeoniae rubra, 4-6 parts of betel nuts, 3-5 parts of rhubarb roots, 1-4 parts of Chinese cinnamon, 1-4 parts of equisctum ramosissimum, 1-3 parts of liquorice and 4-6 partsof radix rehmanniae. According to the scheme, the medicine components assist one another, and the traditional Chinese medicine has a wide treatment effect on diseases such as arthralgia and scleromere pain, and has very high practical value and promotional value.

The invention discloses an application of chitosan engelhardia roxburghiana total flavone nanoparticles in preparation of medicines or health-care foods. The chitosan engelhardia roxburghiana total flavone nanoparticles prepared by the preparation method disclosed by the invention not only have the effect of reducing blood fat, but also have oxidation resistance, can effectively protect the liver, and provide a scientific basis for developing medicines or health-care foods with an obvious lipid-reducing effect; the chitosan engelhardia roxburghiana total flavone nanoparticle disclosed by the invention develops a new thought for subsequent research on prevention and treatment of the non-alcoholic fatty liver disease by the chitosan engelhardia roxburghiana total flavone nanoparticle.

The invention relates to a medicine for treating diabetes insipidus. The medicine is prepared from the following medicinal materials in parts by weight: 6 parts of alpiniae oxyphyllae fructus, 11 parts of radices trichosanthis, 12 parts of cherokee rose fruits, 5 parts of tassel, 14 parts of fructus cannabis, 8 parts of bark of engelhardia roxburghiana and 30 parts of prunus serrulata. The alpiniae oxyphyllae fructus is used for warming the spleen, stopping diarrhea, reducing saliva, warming the kidneys, reducing urination and securing essence; the radices trichosanthis is used for clearing heat, engendering liquid, moistening the lung for removing phlegm, reducing swelling and expelling pus; the cherokee rose fruits are used for securing essence, reducing urination and astringing intestines to stop vaginal discharge; rhizoma curculiginis is used for warming the kidneys, tonifying yang, removing cold dampness; the tassel is used for dispersing wind, clearing heat, descending qi and reducing phlegm; the fructus cannabis is used for moistening dryness, lubricating the intestines, relieving stranguria by diuresis and activating blood circulation; and the bark of engelhardia roxburghiana is used for promoting qi circulation, resolving dampness, guiding stagnation, and securing essence. The medicines work together to reach the efficacies of clearing the stomach, purging intense heat, nourishing yin, engendering liquid, benefiting qi, reducing urination, nourishing the kidneys and securing essence. A clinical experiment proves that the diabetes insipidus can be safely and effectively treated.

The invention discloses health preserving tea with a liver protecting function. The health preserving tea comprises, by weight, 5-20 parts of engelhardia roxburghiana and 0.5-2 parts of morinda officinalis. During use, engelhardia roxburghiana and morinda officinalis are obtained, 600-1000 parts of water are added for soaking for 1-2 hours, the mixture is boiled with big fire and decocted for 0.5hour with soft fire, and then a decoction is obtained through filtering. The health preserving tea with the liver protecting function is safe to use, free of toxic and side effects and capable of protecting the liver and tonifying the kidney, avoids the problems of excessively high renal pressure or renal injury and the like during liver protection, can lower the MDA level, reduce the body oxidative stress and prevent cell injury and then protect the liver, and solves the problem of liver cell injury caused by various reasons.

Coverage padding for pigpen disinfection is prepared from the following raw materials in parts by weight: 45-50 parts of attapulgite, 16-20 parts of tourmaline powder, 10-16 parts of bamboo carbon fiber powder, 5-8 parts of rhizoma phragmitis, 5-8 parts of engelhardia roxburghiana, 14-22 parts of radix phytolaccae, 14-22 parts of mulberry root, 12-18 parts of eggplant root, 12-18 parts of radix angelicae, 5-6 parts of gomphrena globosa, 5-6 parts of fructus lycii, 5-6 parts of potassium sorbate, 16-20 parts of gentian, 16-20 parts of stigma maydis and 16-20 parts of assistant. The padding is simple and convenient to prepare and low in cost, has a very good disinfection effect, greatly saves culture cost, can emit far infrared rays to be beneficial to pigs to a certain extent and is very helpful for improving immunity of the pigs, and the use of a disinfectant can be reduced.

The invention discloses a Zhuang nationality medicine composition for treating functional dyspepsia and a preparation method thereof. The composition is prepared from, by weight, the following raw materials: 10-50 parts of papaya, 10-50 parts of dried tangerine peel, 10-40 parts of engelhardia roxburghiana, 10-30 parts of fennel, 10-30 parts of hedysari radix, 10-30 parts of fructus cannabis, 10-25 parts of screwtree roots, 10-25 parts of endothelium corneum gigeriae galli, 10-20 parts of lygodium japonicum and 10-20 parts of honey-fried licorice roots. The Zhuang nationality medicine composition has the advantages that the composition has the effects of clearing the intestinal tract and anus, repelling the toxin, tonifying deficiency and checking diarrhea, can obviously improve the symptoms of diarrhea, upper abdominal pain, upper abdominal distension, nausea and vomiting, has a definite, rapid and stable curative effect, is free of toxic and side effects and is a good medicine for treating functional dyspepsia; the preparation method is simple to operate, and the effects of the medicinal materials can be fully played.

The invention discloses a process for extracting engelhardia roxburghiana glycosides from engelhardia roxburghiana leaves, and belongs to the field of technologies for extracting effective components from engelhardia roxburghiana leaves. The process for extracting the engelhardia roxburghiana glycosides includes steps of smashing, primary decolorization, coarse crystallization, secondary decolorization, macroporous adsorption resin separation and purification, concentration crystallization, drying and the like. The process has the advantages that the extraction yield of the engelhardia roxburghiana glycosides extracted by the aid of the process is higher than 58.92%, the purity of the engelhardia roxburghiana glycosides is higher than 98.24%, and requirements on the engelhardia roxburghiana glycosides to be used as qualitative and quantitative reference substances can be met by the purity.

The invention belongs to the field of food additives, and particularly relates to a purely natural composite sweetening agent for adjusting the flavor of foods. The purely natural composite sweetening agent disclosed by the invention comprises miraculin, engelhardia roxburghiana extracts, a pH adjusting agent and water. The sugariness of the purely natural composite sweetening agent is 5-10 times of that of cane sugar. The sweetening agent is purely natural, free from artificially synthesized sweetening agents, harmless to human bodies and free from calories, cannot be absorbed by human bodies, can improve the flavor of the foods, and cannot cause harm of blood sugar rise, dental caries, obesity and the like; the purely natural composite sweetening agent is moderate in sugariness, and can solve the problems of anorexia and malnutrition; and the purely natural composite sweetening agent can be used for adjusting the flavor of foods of different kinds, such as solid and liquid, and is particularly suitable for adjusting the flavor of sour foods and bitter foods.

The invention provides a formula for treating angina pectoris. The formula is characterized by comprising the following components by weight in grams of 15 grams of radix puerariae, 12 grams of radixbupleuri, 17 grams of radix salviae miltiorrhizae, 10 grams of radix angelica sinensis, 3 grams of Pseudo-ginseng powder, 7 grams of engelhardia roxburghiana, 7 grams of radix et rhizoma rhei, 6 gramsof ginkgoes, 6 grams of white funguses and 30 grams of edestan. The formula for treating angina pectoris is suitable for patients suffering from angina pectoris caused by various situations. The formula has the special curative effects of clearing heat for removing toxicity, clearing heat for promoting diuresis, clearing heat for expelling wind, stimulating the menstrual flow for promoting bloodcirculation, promoting circulation of blood for reducing swelling, promoting blood circulation for dissipating blood stasis, and eliminating stagnation to activate meridians, and is a good medicine for treating angina pectoris.

The invention relates to the technology of oil manufacture, in particular to special tea oil for children and a preparation method of the special tea oil. The special tea oil for the children is prepared by decompressing drying, super-micro crushing, performing enzymolysis and centrifuging camellia seeds, rice bran, maize germs, engelhardia roxburghiana, ginger, fructus perillae, dry momordica charantia, soybeans and radix astragali. The tea oil is high in yield and free from pollution and addition, well maintains active ingredients in raw materials, and is high in content of amino acid and mineral elements, very suitable for children to eat and capable of promoting the development of the body of the children.