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Chitosan engelhardia roxburghiana total flavone nanoparticles and preparation method thereof

A technology of total flavonoids and chitosan, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor targeting and large doses of fatty liver, and achieve less impurities , Uniform size, not easy to mildew effect

Active Publication Date: 2022-04-12
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Studies have shown that the total flavonoids of Huangqi has both hypoglycemic and blood lipid-lowering pharmacological activities, which is consistent with the therapeutic mechanism of non-alcoholic fatty liver, but it is poorly targeted for the treatment of fatty liver and often requires a larger dose, and it has certain bitterness

Method used

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  • Chitosan engelhardia roxburghiana total flavone nanoparticles and preparation method thereof
  • Chitosan engelhardia roxburghiana total flavone nanoparticles and preparation method thereof
  • Chitosan engelhardia roxburghiana total flavone nanoparticles and preparation method thereof

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Embodiment 1

[0053] A preparation method of chitosan total flavonoids of yellow berries nanoparticles, comprising the following steps:

[0054] (1) Extraction of total flavonoids of Huangqi: Weigh an appropriate amount of Huangqi (identified by the associate researcher of Guangxi Academy of Traditional Chinese Medicine as the dried leaves of Huangqi Engelhardia roxburghiana Wall, a plant of the genus Huangqi in the family Juglandaceae), crush it into a coarse powder, and add 10 times Extract with 95% ethanol for 2 days, filter, add 10 times the amount of 75% ethanol to the filter residue for 2 days, filter, add 10 times the amount of 50% ethanol to the filter residue for 2 days, filter, add 10 times the amount of 20% ethanol to the filter residue for 2 days, Combine all the above-mentioned filtrates, filter and obtain a sample of total flavonoids of Huangqi, and then concentrate to obtain a crude product of total flavonoids of Huangqi;

[0055] (2) Purification of total flavonoids of Huang...

Embodiment 2

[0083] According to the method of Example 1, the concentration of chitosan solution, the concentration of STPP aqueous solution, the mild time of ion exchange reaction, the stirring speed and the time were changed to prepare different chitosan total flavonoid nanoparticles of Huangqi. The light transmittance at 700nm of chitosan total flavonoids of Huangqi nanoparticle suspension or the encapsulation efficiency of total flavonoids of Huangqi were compared.

[0084] Effect of Chitosan and STPP Concentration

[0085] Change the concentration of chitosan solution and STPP aqueous solution, all the other are according to embodiment 1. Chitosan solutions with different concentrations and STPP aqueous solution were mixed and stirred, and intramolecular and intermolecular crosslinking occurred to generate chitosan nanoparticles. Its light transmittance can be seen in Table 2.

[0086] The impact of different concentrations of chitosan solution and STPP aqueous solution on the forma...

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Abstract

The preparation method comprises the following steps: adding a chitosan solution into an engelhardia roxburghiana total flavone aqueous solution while stirring, then injecting a sodium tripolyphosphate aqueous solution, carrying out an ion exchange reaction until blue opalescence appears, then adding a chitosan solution into the engelhardia roxburghiana total flavone aqueous solution while stirring, and carrying out an ion exchange reaction to obtain the chitosan engelhardia roxburghiana total flavone nanoparticle. And carrying out rotary evaporation concentration and spray drying on the suspension to obtain the chitosan engelhardia roxburghiana total flavonoid nanoparticle, and carrying out spray drying on the suspension to obtain the chitosan engelhardia roxburghiana total flavonoid nanoparticle. The chitosan engelhardia roxburghiana total flavone nanoparticles prepared by adopting an ionic cross-linking method are spherical, have the size of 100-300nm and have a slow release effect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, and more specifically relates to a chitosan total flavonoid nanoparticle of Huangqi and a preparation method thereof. Background technique [0002] Studies have shown that the total flavonoids of Huangqi has both hypoglycemic and blood lipid-lowering pharmacological activities, which is consistent with the therapeutic mechanism of non-alcoholic fatty liver, but it is poorly targeted for the treatment of fatty liver and often requires a larger dose, and it has A certain bitterness. Contents of the invention [0003] In view of this, in order to reduce the dosage of the total flavonoids of Huangqi and mask its bitter taste, and at the same time to improve the liver targeting of the total flavonoids of Huangqi, the present invention uses nanoparticles as drug carriers, and utilizes the advantages of sustained release and targeting of nanoparticles. characteristics, and further...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K36/815A61P3/06A61P1/16
CPCY02A50/30
Inventor 黄秋燕赖克道潘宣任
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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