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Application of chitosan engelhardia roxburghiana total flavone nanoparticles in preparation of medicines or health foods

A technology of health food and total flavonoids, which is applied in the direction of nano-medicine, food forming, and function of food ingredients, etc. It can solve the problems of poor targeting and large doses of fatty liver, and achieve the effect of concentrated distribution, less impurities, and uniform size

Pending Publication Date: 2022-05-06
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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Problems solved by technology

[0002] Studies have shown that the total flavonoids of Huangqi has both hypoglycemic and blood lipid-lowering pharmacological activities, which is consistent with the therapeutic mechanism of non-alcoholic fatty liver, but it is poorly targeted for the treatment of fatty liver and often requires a larger dose, and it has certain bitterness

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  • Application of chitosan engelhardia roxburghiana total flavone nanoparticles in preparation of medicines or health foods
  • Application of chitosan engelhardia roxburghiana total flavone nanoparticles in preparation of medicines or health foods
  • Application of chitosan engelhardia roxburghiana total flavone nanoparticles in preparation of medicines or health foods

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Embodiment 1

[0044] The application of chitosan total flavonoid nanoparticles of yellow berry in the preparation of medicine or health food, wherein, the preparation method of chitosan total flavonoid nanoparticle of yellow berry comprises the following steps:

[0045] (1) Extraction of total flavonoids of Huangqi: Weigh an appropriate amount of Huangqi (identified by the associate researcher of Guangxi Academy of Traditional Chinese Medicine as the dried leaves of Huangqi Engelhardia roxburghiana Wall, a plant of the genus Huangqi in the family Juglandaceae), crush it into a coarse powder, and add 10 times Extract with 95% ethanol for 2 days, filter, add 10 times the amount of 75% ethanol to the filter residue for 2 days, filter, add 10 times the amount of 50% ethanol to the filter residue for 2 days, filter, add 10 times the amount of 20% ethanol to the filter residue for 2 days, Combine all the above-mentioned filtrates, filter and obtain a sample of total flavonoids of Huangqi, and then...

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Abstract

The invention discloses an application of chitosan engelhardia roxburghiana total flavone nanoparticles in preparation of medicines or health-care foods. The chitosan engelhardia roxburghiana total flavone nanoparticles prepared by the preparation method disclosed by the invention not only have the effect of reducing blood fat, but also have oxidation resistance, can effectively protect the liver, and provide a scientific basis for developing medicines or health-care foods with an obvious lipid-reducing effect; the chitosan engelhardia roxburghiana total flavone nanoparticle disclosed by the invention develops a new thought for subsequent research on prevention and treatment of the non-alcoholic fatty liver disease by the chitosan engelhardia roxburghiana total flavone nanoparticle.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, and more specifically relates to the application of chitosan total flavonoid nanoparticles of yellow berries in the preparation of medicines or health foods. Background technique [0002] Studies have shown that the total flavonoids of Huangqi has both hypoglycemic and blood lipid-lowering pharmacological activities, which is consistent with the therapeutic mechanism of non-alcoholic fatty liver, but it is poorly targeted for the treatment of fatty liver and often requires a larger dose, and it has A certain bitterness. Contents of the invention [0003] In view of this, in order to reduce the dosage of the total flavonoids of Huangqi and mask its bitter taste, and at the same time to improve the liver targeting of the total flavonoids of Huangqi, the present invention uses nanoparticles as drug carriers, and utilizes the advantages of sustained release and targeting of nano...

Claims

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Application Information

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IPC IPC(8): A61K9/52
CPCA61K9/5161A61K36/52A61P1/16A61P3/06A61P39/06A23L33/105A23L29/30A23P10/30B82Y5/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51A23V2002/00A23V2200/30A23V2250/2116A23V2250/511A23V2300/14A23V2300/10
Inventor 赖克道黄秋燕潘宣任李燕婧韦洁
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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