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Astilbin prepared by taking engelhardia roxburghiana leaves as raw material and preparation method of astilbin

A technology for astilbin and raw materials, which is applied in the field of astilbin and its preparation, can solve the problems of difficulty in realizing industrialized production, low purity of prepared products, complicated technical processes, etc., and achieves improved extraction rate and product purity, low cost, The effect of efficient extraction

Active Publication Date: 2020-07-24
YONGZHOU YIDONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in the extraction technology of Astilbin from Huangqi leaves, there are common problems such as low utilization rate, low purity of the prepared product, complicated technical process, and difficulty in realizing industrial production.

Method used

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  • Astilbin prepared by taking engelhardia roxburghiana leaves as raw material and preparation method of astilbin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The method for preparing astilbin by taking Huang Qiye as raw material comprises the following steps:

[0034] (1) Crushing 500KG of dried leaves of Huangqi leaves into 1-2mm fragments; adding 2500L ethyl acetate to reflux for extraction 3 times, each time for 1.5 hours, and combining the extracts;

[0035] (2) Recover the ethyl acetate in the extract, add 500L of deionized water, drive out the remaining ethyl acetate in the extract, and form the water phase, carry out the first step of crystallization at 5°C, the crystallization time is 8h, and filter The crude product is obtained, with a wet weight of about 70KG;

[0036] (3) Dissolve the crude product with 420L of 50% ethanol, add 2.1KG of activated carbon powder after heating to 65°C in a water bath, stir for 3 minutes and then filter to obtain the filtrate;

[0037] (4) The filtrate is passed through a 1m AB-8 resin column, the flow rate is controlled at 1200L / h, and the column is washed with 1500L50% ethanol at a...

Embodiment 2

[0040] The method for preparing astilbin by taking Huang Qiye as raw material comprises the following steps:

[0041] (1) Crush 500KG of dried leaves of Huangqi leaves into 1-2mm pieces; add 3000L ethyl acetate and reflux to extract 3 times, each time for 2 hours, and combine the extracts;

[0042] (2) Recover the ethyl acetate in the extract, add 600L of deionized water, drive out the remaining ethyl acetate in the extract, and form the water phase, and carry out the first step of crystallization at a temperature of 6°C, the crystallization time is 7h, and filter The crude product is obtained, with a wet weight of about 70KG;

[0043] (3) Dissolve the crude product with 500L of 50% ethanol, add 2KG of activated carbon powder after heating to 60°C in a water bath, stir for 5 minutes and then filter to obtain the filtrate;

[0044] (4) Pass the filtrate through 1m 3 D101 resin column, the flow rate is controlled at 1300L / h, and the column is washed with 1500L 50% ethanol at a...

Embodiment 3

[0047] The method for preparing astilbin by taking Huang Qiye as raw material comprises the following steps:

[0048] (1) Crushing 500KG of dry leaves of Huangqi leaves into 1-2mm fragments; adding 2800L ethyl acetate to reflux for extraction 3 times, each time for 2.5 hours, and combining the extracts;

[0049](2) Recover the ethyl acetate in the extract, add 550L of deionized water, drive out the remaining ethyl acetate in the extract, and form a water phase, and carry out the first step of crystallization at a temperature of 7°C, the crystallization time is 6h, and filter The crude product is obtained, with a wet weight of about 70KG;

[0050] (3) Dissolve the crude product in 480L of 50% ethanol, add 2.4KG of activated carbon powder after heating to 62°C in a water bath, stir for 4 minutes and filter to obtain the filtrate;

[0051] (4) Pass the filtrate through 1m 3 AB-8 resin column, the flow rate is controlled at 1500L / h, and the column is washed with 1500L 50% ethano...

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Abstract

The invention discloses astilbin prepared by taking engelhardia roxburghiana leaves as a raw material and a preparation method of the astilbin. The method comprises the following steps of crushing theengelhardia roxburghiana leaves into fragments, carrying out micro-boiling reflux extraction for multiple times by using ethyl acetate, and combining extracting solutions; recovering ethyl acetate inthe extracting solution, adding deionized water, driving out residual ethyl acetate in the extracting solution, and carrying out primary crystallization and filtration to obtain a crude product; dissolving the crude product with ethanol, adding activated carbon powder, stirring and filtering to obtain filtrate; enabling the filtrate to pass through a macroporous adsorption resin column, and eluting with ethanol to obtain effluent; and adding ethyl acetate into the effluent, uniformly stirring and mixing, standing, taking the supernatant, adding deionized water into the supernatant, sequentially concentrating, crystallizing for the second time, filtering to obtain crystals, washing, and drying in vacuum to obtain the product. According to the method provided by the invention, the extraction rate and the product purity of astilbin are obviously improved; and the purpose of quickly and efficiently extracting astilbin at low cost is achieved, and the method can be used for mass productionin factories.

Description

technical field [0001] The present invention relates to the technical field of extracting active ingredients of natural products, and more specifically, relates to astilbin prepared from the leaves of Huangqi as a raw material and a preparation method thereof. Background technique [0002] Huang Qiye is the dry leaf of Engelhardia roxburghi-ana Wall, which is mainly distributed in Guangdong, Guangxi, Yunnan, Fujian and other places, and is rich in resources. In Guangxi and other places, Huangqi leaves are also known as Arhat tea, which has the effects of clearing heat and detoxifying, promoting body fluids and quenching thirst, and relieving heat, and can eliminate heat, food stagnation, and abdominal pain. Dihydroflavones such as astilbin, taxifolin, and citrus glucoside are the main active ingredients in the leaves of Huangqi, among which astilbin has the highest content. Modern studies have shown that astilbin can lower cholesterol, protect the liver, and have labor pain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H1/08C07H17/07
Inventor 张宝堂郑思佳
Owner YONGZHOU YIDONG BIOTECH
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