The invention discloses a preparation method of an environment-friendly and health-care type artificial stone board for interior home. Dry powder of polymer-modified cement mortar is adopted as an adhesive, a activated carbon powder material with high adsorbability and an tourmaline powder material with anion generating capability are added as fillers, under assistance of other artificial stone base layer materials and auxiliaries, the mixture is subjected to vacuumizing, high-frequency vibration, vacuum lamination and moderate-temperature curing in sequence in a mold to produce a square stock or a rough board, and finally the environment-friendly and health-care type artificial stone board for interior home is produced after cutting, thickness setting, grinding and polishing. According to the method, raw materials for the production are cheap and available, artificial stone production equipment used in the prior art can still serve as production equipment, and the production cost is low; and from production, processing to finished product processing, the produced artificial stone is nontoxic, free from contamination and environmental-friendly, and has functions of absorbing toxic gas in air, purifying the air and releasing anion which is beneficial to human body and mind, and further, the living environment of people is improved.