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Roxburgh engelhardtia extractive for preventing and treating autoimmune diseases and preparation method thereof

A technology of extract and Huangqi, which is applied in the direction of metabolic diseases, skin diseases, bone diseases, etc., can solve the problems of lack of immunosuppressive selectivity

Inactive Publication Date: 2013-07-03
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prevention and treatment of autoimmune diseases are mostly chemical drugs, and none of them have immunosuppressive selectivity. Therefore, it is necessary to develop effective drugs for preventing and treating autoimmune diseases with immunosuppressive selectivity.

Method used

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  • Roxburgh engelhardtia extractive for preventing and treating autoimmune diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] 1 kg of Huangqi leaves medicinal material, reflux extraction with 70% ethanol for 3 times, each time for 2 hours, solvent times (V / W) were 10, 8 and 7 respectively, combined extracts, concentrated until no alcohol smell. Adsorbed on AB-8 macroporous adsorption resin, washed with water and 20% ethanol to remove impurities, and then eluted with 50% ethanol, concentrated the eluate to a thick extract, dried under reduced pressure to obtain the extract of Huangqi, and the liquid phase detection total The flavonoid content is about not less than 20%.

Embodiment 2

[0015] 2 kg of Huangqi leaves medicinal material, reflux extraction with 60% ethanol for 3 times, each time for 2 hours, solvent times (V / W) were 12, 10 and 8 respectively, combined extracts, concentrated until no alcohol smell, adsorbed on NKA9 macropores Adsorbed resin, washed with water and 10% ethanol to remove impurities, then eluted with 40% ethanol, concentrated the eluate to a thick extract, dried under reduced pressure to obtain the extract of Huang Qi, and the total flavonoid content of liquid phase detection was not less than 20% %.

Embodiment 3

[0017] 5 kg of Huangqi leaves medicinal material, reflux extraction with 80% ethanol for 3 times, each time for 2 hours, solvent times (V / W) were 10, 10 and 8 respectively, combined extracts, concentrated until no alcohol smell, adsorbed on HPD400 macropores Adsorbed resin, washed with water and 30% ethanol to remove impurities, then eluted with 60% ethanol, concentrated the eluate to a thick extract, dried under reduced pressure to obtain the extract of Huang Qi, and the total flavonoid content of liquid phase detection was not less than 20% %.

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Abstract

The invention provides a traditional Chinese medicine extractive used for preventing and treating autoimmune diseases. The extract is prepared by extracting roxburgh engelhardtia leaves and purifying with macroporous resin, and can be used for preventing and treating autoimmune diseases, particularly for preventing and treating rheumatoid arthritis and other autoreactive T cell-mediated autoimmune diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the medical use of the extract of Huang Qi, specifically to the preparation process of the extract of Huang Qi and its use as an immunosuppressive drug for preventing and treating autoimmune diseases. Background technique [0002] The immune system is an organizational system for the body to perform immune responses and immune functions, and is composed of immune organs and tissues, immune cells and immune molecules. The immune system is the most effective weapon for the body to defend against the invasion of pathogens. It can find and remove factors that cause fluctuations in the internal environment, such as foreign bodies and foreign pathogenic microorganisms. Immune insufficiency diseases occur when the immune system function is weakened, leading to superinfection of germs and jeopardizing the survival of the individual. On the contrary, the immunophysiolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P1/16A61P3/10A61P17/06A61P19/02A61P21/04A61P25/00A61P29/00A61P37/02A61K127/00
Inventor 单淇于冰侯文彬张新鑫周福军华洁
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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