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Application of engelhardia roxburghiana leaf extract as alpha-glucosidase inhibitor

A technology of glucosidase and leaf extract, which is applied in the fields of medical technology and food, and can solve the problems of gastrointestinal disorders, inability to effectively control complications, etc.

Pending Publication Date: 2022-07-29
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently clinically approved α-glucosidase inhibitors include acarbose, voglibose, and miglitol, etc. These inhibitors have adverse reactions such as abdominal discomfort, gastrointestinal disorders, and diarrhea, and cannot effectively control complications

Method used

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  • Application of engelhardia roxburghiana leaf extract as alpha-glucosidase inhibitor
  • Application of engelhardia roxburghiana leaf extract as alpha-glucosidase inhibitor
  • Application of engelhardia roxburghiana leaf extract as alpha-glucosidase inhibitor

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preparation example Construction

[0125] The present invention also provides a preparation process of the above effervescent agent, wherein the effervescent agent is an effervescent tablet, and the preparation process includes: preparing by a direct compression method.

[0126] According to the embodiment of the present invention, the preparation process of the effervescent tablet specifically includes: sieving the raw and auxiliary materials of the effervescent tablet, and directly compressing the tablet after mixing.

[0127] The present invention provides a method for inhibiting the activity of α-glucosidase, comprising the steps of using the above-mentioned α-glucosidase inhibitor or the above-mentioned composition.

Embodiment approach

[0128] According to an embodiment of the present invention, the method is a method of inhibiting alpha-glucosidase activity in vivo or in vitro.

[0129] In certain embodiments, the method is an in vitro method of inhibiting alpha-glucosidase activity.

[0130] In certain embodiments, the method is a method of inhibiting alpha-glucosidase activity for non-disease diagnostic and therapeutic purposes.

[0131] Huangqi leaves are purchased from Youlvhuan Ecological Agriculture Company, and other raw materials and reagents used in the present invention can be purchased from the market.

[0132] Below in conjunction with embodiment, the present invention is further elaborated:

Embodiment 1

[0134] Preparation of alcohol extract of Huangqi leaves

[0135] The preparation method of the alcohol extract of Huangqi leaves:

[0136] (1) sifting through a 60-mesh sieve after pulverizing the dried leaves of Huang Qi (Youlvhuan Ecological Agriculture Company) to obtain Huang Qi leaf powder;

[0137] (2) after dissolving the Huangqi leaf powder with 55vol% ethanol at a solid-liquid ratio of 1:15, using microwave-assisted extraction, and extracting at 49° C. for 57 s to obtain a Huangqi leaf extract;

[0138] (3) Filtration and concentration under reduced pressure of the extract of Huangqi leaves to extract, and then vacuum freeze-drying for 24h to obtain the alcohol extract of Huangqi leaves.

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Abstract

The invention relates to the field of medicines, and discloses application of engelhardia roxburghiana leaf extract as an alpha-glucosidase inhibitor. The composition containing the engelhardia roxburghiana leaf extract has alpha-glucosidase inhibitory activity, has an obvious curative effect of reducing blood sugar and a certain blood fat reducing effect, and can obviously improve the condition of lipid metabolism disorder in a diabetic mouse; the composition disclosed by the invention is an effervescent tablet and has the advantages of small angle of repose, short disintegration time, high hardness, high foaming amount, moderate pH and moderate sweetness.

Description

technical field [0001] The invention relates to the fields of medical technology and food, and in particular relates to the application of a Huangqi leaf extract as an α-glucosidase inhibitor. Background technique [0002] Diabetes mellitus (diabetes mellitus) is a group of metabolic diseases, mainly due to the absolute or relative insufficiency of insulin secretion and the decreased sensitivity of target cells to insulin, resulting in disturbances of sugar, fat and protein metabolism. People with diabetes often experience symptoms such as polyuria, thirst, persistent hunger, weight loss, vision changes, and fatigue. [0003] For different types of diabetes, the current treatment methods can be mainly divided into oral hypoglycemic drugs and insulin injection treatment. Among them, oral hypoglycemic drugs can be divided into four categories according to their mechanism of action: [0004] 1. Inhibition of α-glucosidase, such as acarbose, voglibose, miglitol, etc. [0005] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61K9/20A61K47/26A61K47/10A61K47/02A61K47/12A61P3/10A61P3/06A23L33/105A23L2/40A61K127/00
CPCA61K36/52A61K9/0007A61K9/2095A61K9/2018A61K9/2031A61K9/2013A61K9/2009A61P3/10A61P3/06A23L33/105A23L2/40A61K2236/333A61K2236/51A23V2002/00A23V2200/3262A23V2200/328A23V2250/21
Inventor 郭晓强张雨铖幸红霞周婷姚倩康泰然刘佳豪
Owner CHENGDU UNIV
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